4ZHT

Crystal structure of UDP-GlcNAc 2-epimerase

Summary for 4ZHT

Entry DOI	10.2210/pdb4zht/pdb
Descriptor	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, URIDINE-5'-DIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE-5-N-ACETYLNEURAMINIC ACID, ... (5 entities in total)
Functional Keywords	inhibitor, complex, epimerase, isomerase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9Y223
Total number of polymer chains	4
Total formula weight	192596.48
Authors	Chen, S.C.,Yang, C.S.,Ko, T.P.,Chen, Y. (deposition date: 2015-04-27, release date: 2016-06-01, Last modification date: 2020-07-29)
Primary citation	Chen, S.C.,Huang, C.H.,Lai, S.J.,Yang, C.S.,Hsiao, T.H.,Lin, C.H.,Fu, P.K.,Ko, T.P.,Chen, Y. Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis. Sci Rep, 6:23274-23274, 2016 Cited by PubMed: 26980148 DOI: 10.1038/srep23274 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.69 Å)

Structure validation