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PDB: 176 件
7XVH
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Crystal structure of AtHPPD-Y13287 complex
分子名称: 1,5-dimethyl-3-(2-methylphenyl)-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Lin, H.-Y, Dong, J, Yang, G.-F.
登録日2022-05-23
公開日2023-01-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.
J.Agric.Food Chem., 71, 2023
5YY6
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Crystal structure of Arabidopsis thaliana HPPD truncated mutant complexed with Benquitrione
分子名称: 3-(2,6-dimethylphenyl)-1-methyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Yang, W.C, Chen, J.N, Yang, G.F.
登録日2017-12-08
公開日2019-01-16
最終更新日2019-10-09
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery.
Research (Wash D C), 2019, 2019
8IM2
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Crystal structure of human HPPD complexed with NTBC
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, 4-hydroxyphenylpyruvate dioxygenase, ...
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-03-05
公開日2023-10-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.
Structure, 31, 2023
6JX9
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Structure of Y17107 complexed HPPD
分子名称: 4-hydroxyphenylpyruvate dioxygenase, 5-[(~{Z})-(1,3-dimethyl-5-oxidanylidene-pyrazol-4-ylidene)-oxidanyl-methyl]-2-(phenylmethyl)isoindole-1,3-dione, COBALT (II) ION
著者Lin, H.Y, Yang, G.F.
登録日2019-04-22
公開日2020-03-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.
J.Agric.Food Chem., 67, 2019
5YY7
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Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione
分子名称: 3-(2,6-dimethylphenyl)-1-methyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Yang, W.C, Chen, J.N, Yang, G.F.
登録日2017-12-08
公開日2019-01-16
実験手法X-RAY DIFFRACTION (3.298 Å)
主引用文献Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione (Y13161)
To be published
8HID
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HUMAN ERYTHROCYTE CATALSE COMPLEXED WITH BT-Br
分子名称: (~{S})-azanyl-[2-[[3-bromanyl-4-(diethylamino)phenyl]methyl]hydrazinyl]methanethiol, Catalase, PROTOPORPHYRIN IX CONTAINING FE
著者Lin, H.-Y, Yang, G.-F.
登録日2022-11-19
公開日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A catalase inhibitor: Targeting the NADPH-binding site for castration-resistant prostate cancer therapy.
Redox Biol, 63, 2023
8IOG
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Cryo-EM structure of porcine bc1 complex in isolated state
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, Complex III subunit 9, ...
著者Wang, Y.X, Dong, J.Q, Yang, G.F.
登録日2023-03-11
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Cryo-EM structure of porcine bc1 complex in isolated state
To Be Published
8WTZ
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potassium outward rectifier channel SKOR
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR
著者Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G.
登録日2023-10-19
公開日2024-04-10
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 5, 2024
8WUI
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SKOR D312N L271P double mutation
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR
著者Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G.
登録日2023-10-20
公開日2024-04-10
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 5, 2024
1YM4
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Crystal structure of human beta secretase complexed with NVP-AMK640
分子名称: Beta-secretase 1, NVP-AMK640 INHIBITOR
著者Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S.
登録日2005-01-20
公開日2006-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
J.Med.Chem., 48, 2005
1YM2
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Crystal structure of human beta secretase complexed with NVP-AUR200
分子名称: Beta-secretase 1, NVP-AUR200 INHIBITOR
著者Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S.
登録日2005-01-20
公開日2006-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
J.Med.Chem., 48, 2005
5ZOI
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BU of 5zoi by Molmil
Crystal Structure of alpha1,3-Fucosyltransferase
分子名称: Alpha-(1,3)-fucosyltransferase FucT, [[(2S,3R,4S,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5R,6R)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate
著者Tan, Y, Yang, G.
登録日2018-04-13
公開日2019-06-26
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Directed evolution of an alpha 1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method.
Sci Adv, 5, 2019
6IYC
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Recognition of the Amyloid Precursor Protein by Human gamma-secretase
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y.
登録日2018-12-14
公開日2019-01-23
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
7E0X
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Crystal structure of Arabidopsis thaliana HPPD complexed with 4-hydroxyphenylacetic acid
分子名称: 4-HYDROXYPHENYLACETATE, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Lin, H.Y, Yang, G.F.
登録日2021-01-28
公開日2021-12-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.887 Å)
主引用文献Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study.
J.Am.Chem.Soc., 143, 2021
8GQT
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Structure of Mpro complexed with Quercetin
分子名称: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, 3C-like proteinase nsp5
著者Dong, J, Yang, G.-F.
登録日2022-08-30
公開日2023-08-30
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structure of Mpro complexed with Quercetin
To Be Published
8HZA
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BU of 8hza by Molmil
Crystal structure of AtHPPD-YH20326 complex
分子名称: 1,4-dimethyl-3-(oxan-4-ylmethyl)-5-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-benzimidazol-2-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-08
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Crystal structure of AtHPPD-YH20326 complex
To Be Published
8HXH
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Crystal structure of AtHPPD-Y18024 complex
分子名称: 1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-propyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-04
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.992 Å)
主引用文献Crystal structure of AtHPPD-Y18024 complex
To Be Published
8HYS
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Crystal structure of AtHPPD-Y19802 complex
分子名称: 1-methyl-3-[2-methyl-6-methylsulfonyl-3-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-phenyl]-6-(trifluoromethyl)pyrimidine-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-07
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of AtHPPD-Y19802 complex
To Be Published
8HWR
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Crystal structure of AtHPPD-Y191193 complex
分子名称: 4-hydroxyphenylpyruvate dioxygenase, 6-chloranyl-3-cyclopentyl-1-methyl-7-(2-oxidanyl-6-oxidanylidene-cyclohexa-1,3-dien-1-yl)carbonyl-quinazoline-2,4-dione, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-02
公開日2023-12-20
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal structure of AtHPPD-Y191193 complex
To Be Published
8I36
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Crystal structure of AtHPPD-Y18980 complex
分子名称: 1,5-dimethyl-3-(naphthalen-1-ylmethyl)-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-16
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.887 Å)
主引用文献Crystal structure of AtHPPD-Y18980 complex
To Be Published
8HYP
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Crystal structure of AtHPPD-Y18400 complex
分子名称: 3-[(4-fluorophenyl)methyl]-1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-07
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Crystal structure of AtHPPD-Y18400 complex
To Be Published
8HZ7
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Crystal structure of AtHPPD-Y181135 complex
分子名称: 3-butyl-5-methyl-6-[(2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,2,3-benzotriazin-4-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-08
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Crystal structure of AtHPPD-Y181135 complex
To Be Published
8I0G
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Crystal structure of AtHPPD-Y19543 complex
分子名称: 3-[(4-fluorophenyl)methyl]-5-methyl-6-[(2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,2,3-benzotriazin-4-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-10
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.992 Å)
主引用文献Crystal structure of AtHPPD-Y19543 complex
To Be Published
8I2P
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Crystal structure of AtHPPD-Y19060 complex
分子名称: 3-(cyclopropylmethyl)-6-[(5-cyclopropyl-2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,5-dimethyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-14
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Crystal structure of AtHPPD-Y19060 complex
To Be Published
8HXF
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Crystal structure of AtHPPD-Y181188 complex
分子名称: 4-hydroxyphenylpyruvate dioxygenase, 6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one, COBALT (II) ION
著者Dong, J, Lin, H.-Y, Yang, G.-F.
登録日2023-01-04
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.697 Å)
主引用文献Crystal structure of AtHPPD-Y181188 complex
To Be Published

225946

件を2024-10-09に公開中

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