2K4F
 
 | | Mouse CD3epsilon Cytoplasmic Tail | | Descriptor: | T-cell surface glycoprotein CD3 epsilon chain | | Authors: | Xu, C, Call, M.E, Schwieters, C.D, Schnell, J.R, Gagnon, E.E, Wucherpfennig, K.W, Chou, J.J. | | Deposit date: | 2008-06-07 | | Release date: | 2008-12-02 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3varepsilon Cytoplasmic Tyrosine-Based Motif.
Cell(Cambridge,Mass.), 135, 2008
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4LG7
 | | Crystal structure MBD4 MBD domain in complex with methylated CpG DNA | | Descriptor: | DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 4, UNKNOWN ATOM OR ION | | Authors: | Xu, C, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2013-06-27 | | Release date: | 2013-07-17 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
To be Published
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4R6M
 | | Crystal Structure of DNA Duplex Containing Two Consecutive Mercury-mediated Base Pairs | | Descriptor: | DNA (5'-D(P*CP*GP*CP*GP*TP*TP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*TP*TP*CP*GP*CP*G)-3'), MERCURY (II) ION | | Authors: | Xu, C.Y, Yu, F, Wang, L.H, Zhao, Y, Lin, T, Fan, C.H, He, J.H. | | Deposit date: | 2014-08-26 | | Release date: | 2015-09-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.357 Å) | | Cite: | Crystal Structure of DNA Duplex Containing Two Consecutive Mercury-mediated Base Pairs
To be Published
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4HBD
 | | Crystal structure of KANK2 ankyrin repeats | | Descriptor: | KN motif and ankyrin repeat domain-containing protein 2, UNKNOWN ATOM OR ION | | Authors: | Xu, C, Tempel, W, Cerovina, T, El Bakkouri, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-09-27 | | Release date: | 2012-12-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Crystal structure of KANK2 ankyrin repeats
To be Published
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3QMH
 | | Structural Basis of Selective Binding of Non-Methylated CpG islands (DNA-TCGA) by the CXXC Domain of CFP1 | | Descriptor: | 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', CpG-binding protein, ZINC ION | | Authors: | Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-02-04 | | Release date: | 2011-02-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.
Nat Commun, 2, 2011
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3QMI
 | | Structural Basis of Selective Binding of Non-Methylated CpG islands (DNA-ACGT) by the CXXC Domain of CFP1 | | Descriptor: | 5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3', CpG-binding protein, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-02-04 | | Release date: | 2011-02-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.
Nat Commun, 2, 2011
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3QMG
 | | Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1 | | Descriptor: | 5'-D(*GP*CP*CP*AP*AP*CP*GP*GP*TP*GP*GP*C)-3', 5'-D(*GP*CP*CP*AP*CP*CP*GP*TP*TP*GP*GP*C)-3', CpG-binding protein, ... | | Authors: | Xu, C, Bian, C, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-02-04 | | Release date: | 2011-02-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.
Nat Commun, 2, 2011
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7EC5
 | | EV-D68 in complex with 8F12 Fab | | Descriptor: | 8F12 Fab heavy chain, 8F12 Fab light chain, Capsid protein VP1, ... | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2021-03-11 | | Release date: | 2021-03-31 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections.
Nat Commun, 12, 2021
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7ECY
 | | EV-D68 in complex with 2H12 Fab (State 3) | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2021-03-13 | | Release date: | 2021-03-31 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections.
Nat Commun, 12, 2021
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7EBR
 | | EV-D68 in complex with 2H12 Fab (state S2) | | Descriptor: | 2H12 Fab heavy chain, 2H12 Fab light chain, Capsid protein VP1, ... | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2021-03-10 | | Release date: | 2021-03-31 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections.
Nat Commun, 12, 2021
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7EBZ
 | | EV-D68 in complex with 2H12 Fab (state S1) | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2021-03-11 | | Release date: | 2021-03-31 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections.
Nat Commun, 12, 2021
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7DR7
 | | bovine 20S immunoproteasome | | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2020-12-26 | | Release date: | 2021-01-20 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM of mammalian PA28 alpha beta-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28 alpha beta.
Nat Commun, 12, 2021
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7DK3
 | | SARS-CoV-2 S trimer, S-open | | Descriptor: | Spike glycoprotein | | Authors: | Xu, C, Cong, Y. | | Deposit date: | 2020-11-23 | | Release date: | 2020-12-16 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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4LG8
 | | Crystal structure of PRPF19 WD40 repeats | | Descriptor: | Pre-mRNA-processing factor 19, SODIUM ION, UNKNOWN ATOM OR ION | | Authors: | Xu, C, Tempel, W, He, H, Dobrovetsky, E, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2013-06-27 | | Release date: | 2013-08-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal structure of the WD40 domain of human PRPF19.
Biochem. Biophys. Res. Commun., 493, 2017
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5J0I
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | Descriptor: | Designed protein 2L6HC3_12 | | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | Deposit date: | 2016-03-28 | | Release date: | 2016-05-25 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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5J0K
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | Descriptor: | designed protein 2L4HC2_23 | | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | Deposit date: | 2016-03-28 | | Release date: | 2016-05-25 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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5J0H
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | Descriptor: | Design construct 2L6HC3_13 | | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | Deposit date: | 2016-03-28 | | Release date: | 2016-05-25 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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5J10
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | Descriptor: | peptide design 2L4HC2_24 | | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | Deposit date: | 2016-03-28 | | Release date: | 2016-05-25 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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5J0L
 | | De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity | | Descriptor: | designed protein 3L6HC2_2 | | Authors: | Sankaran, B, Zwart, P.H, Pereira, J.H, Baker, D, Boyken, S, Chen, Z, Groves, B, Langan, R.A, Oberdorfer, G, Ford, A, Gilmore, J, Xu, C, DiMaio, F, Seelig, G. | | Deposit date: | 2016-03-28 | | Release date: | 2016-07-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
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3J8Y
 | | High-resolution structure of ATP analog-bound kinesin on microtubules | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Shang, Z, Zhou, K, Xu, C, Csencsits, R, Cochran, J.C, Sindelar, C.V. | | Deposit date: | 2014-11-20 | | Release date: | 2014-12-10 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation.
Elife, 3, 2014
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6U1S
 | | Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R. | | Descriptor: | de novo designed 16-helix transmembrane nanopore, TMHC8_R | | Authors: | Johnson, M.J, Reggiano, G, Xu, C, Lu, P, Hsia, Y, Brunette, T.J, DiMaio, F, Baker, D, Kollman, J. | | Deposit date: | 2019-08-16 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Computational Design of Transmembrane Channels
To Be Published
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6M6Z
 | | A de novo designed transmembrane nanopore, TMH4C4 | | Descriptor: | TMH4C4 | | Authors: | Lu, P, Xu, C, Reggiano, G, Xu, Q, DiMaio, F, Baker, D. | | Deposit date: | 2020-03-16 | | Release date: | 2020-06-24 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Computational design of transmembrane pores.
Nature, 585, 2020
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8ZQ3
 | | Structure of ORP1L-RAB7A in the presence of GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Oxysterol-binding protein-related protein 1, Ras-related protein Rab-7a | | Authors: | Lu, Q, Zhang, J, Xu, C. | | Deposit date: | 2024-05-31 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structure of GDP-bound Rab7 Q67L in complex with ORP1L.
Biochem.Biophys.Res.Commun., 725, 2024
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8J8I
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7Y3I
 | | Structure of DNA bound SALL4 | | Descriptor: | DNA (12-mer), Sal-like protein 4, ZINC ION | | Authors: | Ru, W, Xu, C. | | Deposit date: | 2022-06-10 | | Release date: | 2022-10-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
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