4ZRS
 
 | | Crystal structure of a cloned feruloyl esterase from a soil metagenomic library | | Descriptor: | Esterase, GLYCEROL | | Authors: | Xie, W, Chen, R, Cao, L, Liu, Y. | | Deposit date: | 2015-05-12 | | Release date: | 2016-02-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Enhancing the Thermostability of Feruloyl Esterase EstF27 by Directed Evolution and the Underlying Structural Basis
J.Agric.Food Chem., 63, 2015
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6EDC
 | | hcGAS-16bp dsDNA complex | | Descriptor: | Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ... | | Authors: | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | | Deposit date: | 2018-08-09 | | Release date: | 2019-05-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.712 Å) | | Cite: | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7SHP
 | | Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244) | | Descriptor: | (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | | Authors: | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | | Deposit date: | 2021-10-11 | | Release date: | 2022-10-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
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7SHO
 | | Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242) | | Descriptor: | (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | | Authors: | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | | Deposit date: | 2021-10-10 | | Release date: | 2022-10-12 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
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5WT3
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5HJM
 | | Crystal Structure of Pyrococcus abyssi Trm5a complexed with MTA | | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, ACETATE ION, HOMOSERINE LACTONE, ... | | Authors: | Xie, W, Wang, C, Jia, Q. | | Deposit date: | 2016-01-13 | | Release date: | 2016-10-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.762 Å) | | Cite: | Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep, 6, 2016
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5HP7
 | | Crystal structures of RidA in the apo form | | Descriptor: | Reactive Intermediate Deaminase A, chloroplastic | | Authors: | Xie, W, Liu, X. | | Deposit date: | 2016-01-20 | | Release date: | 2016-10-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of RidA, an important enzyme for the prevention of toxic side products
Sci Rep, 6, 2016
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6L5A
 | | The structure of the UdgX mutant H109E at a pre-excision state | | Descriptor: | GLYCEROL, IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | Authors: | Xie, W, Tu, J, Zeng, H. | | Deposit date: | 2019-10-22 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.80007327 Å) | | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.
DNA Repair (Amst), 97, 2021
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1Q2S
 | | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate | | Descriptor: | 5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(PQ1)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3', 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase, ... | | Authors: | Xie, W, Liu, X, Huang, R.H. | | Deposit date: | 2003-07-25 | | Release date: | 2003-09-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate
Nat.Struct.Biol., 10, 2003
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1Q2R
 | | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate | | Descriptor: | 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase, RNA (5'-R(*AP*GP*CP*AP*CP*GP*GP*CP*UP*(N)P*UP*AP*AP*AP*CP*CP*GP*UP*GP*C)-3'), ... | | Authors: | Xie, W, Liu, X, Huang, R.H. | | Deposit date: | 2003-07-25 | | Release date: | 2003-09-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate
Nat.Struct.Biol., 10, 2003
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6EDB
 | | Crystal structure of SRY.hcGAS-21bp dsDNA complex | | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), Sex-determining region Y protein,Cyclic GMP-AMP synthase, ... | | Authors: | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | | Deposit date: | 2018-08-09 | | Release date: | 2019-05-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.209 Å) | | Cite: | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6KYS
 | | The structure of the M. tb toxin MazF-mt1 | | Descriptor: | Endoribonuclease MazF9 | | Authors: | Xie, W, Chen, R, Zhou, J. | | Deposit date: | 2019-09-20 | | Release date: | 2020-08-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.200414 Å) | | Cite: | Conserved Conformational Changes in the Regulation ofMycobacterium tuberculosisMazEF-mt1.
Acs Infect Dis., 6, 2020
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6L2A
 | | A mutant form of M. tb toxin MazEF-mt1 | | Descriptor: | mRNA interferase | | Authors: | Xie, W, Chen, R, Zhou, J. | | Deposit date: | 2019-10-03 | | Release date: | 2020-08-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.90044665 Å) | | Cite: | Conserved Conformational Changes in the Regulation ofMycobacterium tuberculosisMazEF-mt1.
Acs Infect Dis., 6, 2020
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6L2L
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6L2M
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7D88
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4XPU
 | | The crystal structure of EndoV from E.coli | | Descriptor: | Endonuclease V | | Authors: | Xie, W, Zhang, Z. | | Deposit date: | 2015-01-18 | | Release date: | 2015-08-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of E. coli endonuclease V, an essential enzyme for deamination repair
Sci Rep, 5, 2015
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7D89
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7DBF
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7DC9
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7DCA
 | | The structure of the Arabidopsis thaliana guanosine deaminase bound by xanthosine | | Descriptor: | 2,3-dihydroxanthosine, Guanosine deaminase, ZINC ION | | Authors: | Xie, W, Jia, Q, Zeng, H. | | Deposit date: | 2020-10-23 | | Release date: | 2021-09-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.
Chem.Commun.(Camb.), 57, 2021
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7DCB
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7DCW
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7DH1
 | | The structure of the Arabidopsis thaliana guanosine deaminase in reaction with N2-Methylguanosine | | Descriptor: | 2,3-dihydroxanthosine, Guanosine deaminase, ZINC ION | | Authors: | Xie, W, Jia, Q, Zeng, H. | | Deposit date: | 2020-11-12 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Substrate Specificity of GSDA Revealed by Cocrystal Structures and Binding Studies.
Int J Mol Sci, 23, 2022
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7DPK
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