2ISP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2isp by Molmil](/molmil-images/mine/2isp) | Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-methylene triphosphate | Descriptor: | 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... | Authors: | Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A. | Deposit date: | 2006-10-18 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46, 2007
|
|
2ISO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2iso by Molmil](/molmil-images/mine/2iso) | Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate | Descriptor: | 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... | Authors: | Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A. | Deposit date: | 2006-10-18 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46, 2007
|
|
7XEY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xey by Molmil](/molmil-images/mine/7xey) | EDS1-PAD4 complexed with pRib-ADP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Huang, S, Jia, A, Xiao, Y. | Deposit date: | 2022-03-31 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science, 377, 2022
|
|
6KW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kw1 by Molmil](/molmil-images/mine/6kw1) | The structure of the metallo-beta-lactamase VIM-2 in complex with a triazolylthioacetamide 1b | Descriptor: | 2-[3-[2-(1H-benzimidazol-2-ylamino)-2-oxidanylidene-ethyl]sulfanyl-1H-1,2,4-triazol-5-yl]benzoic acid, ACETATE ION, Beta-lactamase class B VIM-2, ... | Authors: | Yang, K.W, Xiang, Y. | Deposit date: | 2019-09-05 | Release date: | 2020-09-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.775212 Å) | Cite: | Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-beta-Lactamase 2 (VIM-2) Inhibitor. Biomolecules, 10, 2020
|
|
7EJV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ejv by Molmil](/molmil-images/mine/7ejv) | The co-crystal structure of DYRK2 with YK-2-69 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone | Authors: | Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P. | Deposit date: | 2021-04-02 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Nat Commun, 13, 2022
|
|
7V7C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v7c by Molmil](/molmil-images/mine/7v7c) | CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex | Descriptor: | DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... | Authors: | Wang, D, Xu, J, Liu, Q, Xiang, Y. | Deposit date: | 2021-08-21 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
|
|
7V7B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v7b by Molmil](/molmil-images/mine/7v7b) | |
7DJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dj1 by Molmil](/molmil-images/mine/7dj1) | Crystal structure of the G26C mutant of LeuT | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.528 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
|
|
7DII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dii by Molmil](/molmil-images/mine/7dii) | Crystal structure of LeuT in lipidic cubic phase at pH 7 | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
|
|
7DJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dj2 by Molmil](/molmil-images/mine/7dj2) | Crystal structure of the G26C/E290S mutant of LeuT | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
|
|
7DIX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dix by Molmil](/molmil-images/mine/7dix) | Crystal structure of LeuT in lipidic cubic phase at pH 5 | Descriptor: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-19 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
|
|
7DJC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7djc by Molmil](/molmil-images/mine/7djc) | Crystal structure of the G26C/Q250A mutant of LeuT | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-11-20 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
|
|
6JEP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jep by Molmil](/molmil-images/mine/6jep) | Structure of a neutralizing antibody bound to the Zika envelope protein domain III | Descriptor: | Genome polyprotein, heavy chain of Fab ZK2B10, light chain of Fab ZK2B10 | Authors: | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | Deposit date: | 2019-02-07 | Release date: | 2019-05-15 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (2.316 Å) | Cite: | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep, 26, 2019
|
|
6KU9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ku9 by Molmil](/molmil-images/mine/6ku9) | |
7WIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wif by Molmil](/molmil-images/mine/7wif) | The THF-II riboswitch bound to H4B | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, RNA (50-MER) | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7WIE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wie by Molmil](/molmil-images/mine/7wie) | The THF-II riboswitch bound to 7DG | Descriptor: | 7-DEAZAGUANINE, RNA (50-MER) | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7WII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wii by Molmil](/molmil-images/mine/7wii) | The THF-II riboswitch bound to NPR | Descriptor: | 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, RNA (50-MER) | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7WIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wia by Molmil](/molmil-images/mine/7wia) | The apo-form of THF-II C22G riboswitch | Descriptor: | RNA (50-MER) | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7WIB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wib by Molmil](/molmil-images/mine/7wib) | The THF-II riboswitch bound to THF | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, RNA (50-MER) | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7WI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wi9 by Molmil](/molmil-images/mine/7wi9) | The THF-II riboswitch bound to THF and soaking with SeUrea | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, RNA (50-MER), selenourea | Authors: | Xu, L, Fang, X, Xiao, Y. | Deposit date: | 2022-01-03 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural insights into translation regulation by the THF-II riboswitch. Nucleic Acids Res., 51, 2023
|
|
7CZL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czl by Molmil](/molmil-images/mine/7czl) | Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus | Descriptor: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Pi, X, Huang, G, Xiao, Y. | Deposit date: | 2020-09-09 | Release date: | 2021-01-20 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus . Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7DM2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dm2 by Molmil](/molmil-images/mine/7dm2) | crystal structure of the M. tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-170 | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | Authors: | Ma, B, Freund, N, Xiang, Y. | Deposit date: | 2020-12-01 | Release date: | 2020-12-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun, 12, 2021
|
|
7DM1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dm1 by Molmil](/molmil-images/mine/7dm1) | crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | Authors: | Ma, B, Freund, N, Xiang, Y. | Deposit date: | 2020-12-01 | Release date: | 2020-12-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun, 12, 2021
|
|
7XY1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xy1 by Molmil](/molmil-images/mine/7xy1) | |
7XYC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xyc by Molmil](/molmil-images/mine/7xyc) | |