6KW1

The structure of the metallo-beta-lactamase VIM-2 in complex with a triazolylthioacetamide 1b

Summary for 6KW1

• Entry DOI: 10.2210/pdb6kw1/pdb
• Descriptor: Beta-lactamase class B VIM-2, ZINC ION, CHLORIDE ION, ... (9 entities in total)
• Functional Keywords: antibiotic resistant, metallo-beta-lactamase vim-2 inhibitor, trizolylthioacetamides, crystallographic study, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 58248.64

Authors

Yang, K.W.,Xiang, Y. (deposition date: 2019-09-05, release date: 2020-09-09, Last modification date: 2023-11-22)

• Primary citation: Xiang, Y.,Zhang, Y.J.,Ge, Y.,Zhou, Y.,Chen, C.,Wahlgren, W.Y.,Tan, X.,Chen, X.,Yang, K.W.; Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-beta-Lactamase 2 (VIM-2) Inhibitor.; Biomolecules, 10:-, 2020; PubMed: 31906402; DOI: 10.3390/biom10010072

Experimental method

X-RAY DIFFRACTION (1.77521201035 Å)