7V3E
 
 | | The complex structure of soBcmB and its intermediate product 1a | | Descriptor: | (3S,6Z)-3-[(2S)-butan-2-yl]-6-[(2R)-2-methyl-2,3-bis(oxidanyl)propylidene]piperazine-2,5-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V2U
 | | The complex structure of SoBcmB and its product 2f | | Descriptor: | (1S,5S,6S)-5-methyl-1-[(1S,2S)-2-methyl-1,2,3-tris(oxidanyl)propyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-09 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.00009918 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V34
 | | The complex structure of soBcmB and its product 1d | | Descriptor: | (3S,4S,5S,8S)-8-[(2S)-butan-2-yl]-3-methyl-3,4-bis(oxidanyl)-1-oxa-7,10-diazaspiro[4.5]decane-6,9-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.000169 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V36
 | | The complex structure of soBcmB and its intermediate product 2a | | Descriptor: | (3Z,6S)-3-[(2R)-2-methyl-2,3-bis(oxidanyl)propylidene]-6-[(2S)-4-oxidanylbutan-2-yl]piperazine-2,5-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.96009171 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V3N
 | | The complex structure of soBcmB-D307A and its natural precursor 2 | | Descriptor: | (3S,6S)-3-((R)-2,3-dihydroxy-2-methylpropyl)-6-((S)-4-hydroxybutan-2-yl)piperazine-2,5-dione, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.850011 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V2X
 | | The complex structure of soBcmB and its substrate 1 | | Descriptor: | (3S,6S)-3-[(2S)-butan-2-yl]-6-[(2R)-2-methyl-2,3-bis(oxidanyl)propyl]piperazine-2,5-dion, 2-OXOGLUTARIC ACID, FE (II) ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.08387423 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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7V3O
 | | The structure of Se-SoBcmB with Fe(II)and AKG | | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, FE (II) ION, ... | | Authors: | Wu, L, Zhou, J.H. | | Deposit date: | 2021-08-10 | | Release date: | 2023-02-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.83004665 Å) | | Cite: | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Nat Catal, 6, 2023
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5YNG
 | | Crystal structure of SZ348 in complex with cyclopentene oxide | | Descriptor: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, NICKEL (II) ION, ... | | Authors: | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | | Deposit date: | 2017-10-24 | | Release date: | 2018-06-27 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.497 Å) | | Cite: | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J. Am. Chem. Soc., 140, 2018
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6KTW
 | | structure of EanB with hercynine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-29 | | Release date: | 2020-08-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.931 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KU2
 | | The structure of EanB/Y353A complex with ergothioneine covalent linked with persulfide Cys412 | | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-30 | | Release date: | 2020-08-26 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KTV
 | | The structure of EanB complex with hercynine and persulfided Cys412 | | Descriptor: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, CHLORIDE ION, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-29 | | Release date: | 2020-08-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KTZ
 | | The complex structure of EanB/C412S with hercynine | | Descriptor: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-29 | | Release date: | 2020-08-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KVY
 | | The structure of EanB/T414A complex with hercynine | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, N,N,N-trimethyl-histidine, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-09-05 | | Release date: | 2020-09-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | The structure of EanB/T414A complex with hercynine
To Be Published
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6KW0
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6KTX
 | | The wildtype structure of EanB | | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-29 | | Release date: | 2020-08-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.189 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KVZ
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6KU1
 | | The structure of EanB/Y353A complex with ergothioneine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Wu, L, Liu, P.H, Zhou, J.H. | | Deposit date: | 2019-08-30 | | Release date: | 2020-08-26 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis
Acs Catalysis, 10, 2020
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6KVW
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3TK9
 | | Crystal structure of human granzyme H | | Descriptor: | Granzyme H, SULFATE ION | | Authors: | Wang, L, Zhang, K, Wu, L, Tong, L, Sun, F, Fan, Z. | | Deposit date: | 2011-08-25 | | Release date: | 2011-12-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif
J.Immunol., 188, 2012
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5X5V
 | | Crystal structure of pseudorabies virus glycoprotein D | | Descriptor: | GD | | Authors: | Li, A, Lu, G, Qi, J, Wu, L, Tian, K, Luo, T, Shi, Y, Yan, J, Gao, G.F. | | Deposit date: | 2017-02-17 | | Release date: | 2017-04-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of pseudorabies virus glycoprotein D
To Be Published
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8CHS
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8CD0
 | | Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate, and nanobody nAb7 (composite map and model) | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, CALCIUM ION, ... | | Authors: | Mycroft-West, C.J, Wu, L. | | Deposit date: | 2023-01-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.42 Å) | | Cite: | Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1.
Nat Commun, 15, 2024
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8CCY
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6LN2
 | | Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab7F38_heavy chain, Fab7F38_light chain, ... | | Authors: | Wu, F, Yang, L, Hang, K, Laursen, M, Wu, L, Han, G.W, Ren, Q, Roed, N.K, Lin, G, Hanson, M, Jiang, H, Wang, M, Reedtz-Runge, S, Song, G, Stevens, R.C. | | Deposit date: | 2019-12-28 | | Release date: | 2020-03-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Full-length human GLP-1 receptor structure without orthosteric ligands.
Nat Commun, 11, 2020
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5GI4
 | | DEAD-box RNA helicase | | Descriptor: | ATP-dependent RNA helicase DeaD | | Authors: | Xu, L, Wang, L, Li, F, Wu, L, Shi, Y. | | Deposit date: | 2016-06-22 | | Release date: | 2017-05-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.244 Å) | | Cite: | Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
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