7XI4
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![BU of 7xi4 by Molmil](/molmil-images/mine/7xi4) | Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), ... | Authors: | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | Deposit date: | 2022-04-12 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (4.707 Å) | Cite: | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XHV
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![BU of 7xhv by Molmil](/molmil-images/mine/7xhv) | Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ... | Authors: | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | Deposit date: | 2022-04-10 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.996 Å) | Cite: | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. Proc.Natl.Acad.Sci.USA, 119, 2022
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8JSW
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![BU of 8jsw by Molmil](/molmil-images/mine/8jsw) | Human VMAT2 complex with serotonin | Descriptor: | SEROTONIN, Synaptic vesicular amine transporter | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-20 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JTA
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![BU of 8jta by Molmil](/molmil-images/mine/8jta) | Human VMAT2 complex with tetrabenazine | Descriptor: | Synaptic vesicular amine transporter, tetrabenazine | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JT9
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![BU of 8jt9 by Molmil](/molmil-images/mine/8jt9) | Human VMAT2 complex with ketanserin | Descriptor: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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4NG2
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![BU of 4ng2 by Molmil](/molmil-images/mine/4ng2) | |
8JTC
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![BU of 8jtc by Molmil](/molmil-images/mine/8jtc) | Human VMAT2 complex with reserpine | Descriptor: | Synaptic vesicular amine transporter, reserpine | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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7WD3
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![BU of 7wd3 by Molmil](/molmil-images/mine/7wd3) | Cryo-EM structure of Drg1 hexamer treated with ATP and benzo-diazaborine | Descriptor: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2021-12-21 | Release date: | 2022-12-14 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7WBB
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![BU of 7wbb by Molmil](/molmil-images/mine/7wbb) | Cryo-EM structure of substrate engaged Drg1 hexamer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, AFG2 isoform 1, substrate | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2021-12-16 | Release date: | 2022-12-28 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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8GQO
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![BU of 8gqo by Molmil](/molmil-images/mine/8gqo) | |
5UAN
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![BU of 5uan by Molmil](/molmil-images/mine/5uan) | Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA | Descriptor: | (9cis)-retinoic acid, DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), ... | Authors: | Chandra, V, Wu, D, Kim, Y, Rastinejad, F. | Deposit date: | 2016-12-19 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.508 Å) | Cite: | The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission. Nat Commun, 8, 2017
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7YKT
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![BU of 7ykt by Molmil](/molmil-images/mine/7ykt) | Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-23 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKL
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![BU of 7ykl by Molmil](/molmil-images/mine/7ykl) | Cryo-EM structure of Drg1 hexamer treated with AMPPNP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-22 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKK
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![BU of 7ykk by Molmil](/molmil-images/mine/7ykk) | Cryo-EM structure of Drg1 hexamer treated with ADP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-22 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7YKZ
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![BU of 7ykz by Molmil](/molmil-images/mine/7ykz) | Cryo-EM structure of Drg1 hexamer in the planar state treated with ADP/AMPPNP/Diazaborine | Descriptor: | 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Ma, C.Y, Wu, D.M, Chen, Q, Gao, N. | Deposit date: | 2022-07-25 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition. Nat Commun, 13, 2022
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7XYO
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![BU of 7xyo by Molmil](/molmil-images/mine/7xyo) | Crystal Structure of a M61 aminopeptidase family member from Myxococcus fulvus | Descriptor: | Aminopeptidase M61, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | Authors: | Chen, X, Wang, X, Huo, L, Wu, D. | Deposit date: | 2022-06-02 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity. J.Am.Chem.Soc., 145, 2023
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7W80
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![BU of 7w80 by Molmil](/molmil-images/mine/7w80) | Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | Descriptor: | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Ren, X, Diao, X, Zhuang, J, Wu, D. | Deposit date: | 2021-12-07 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.754 Å) | Cite: | Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan. Mol.Pharmacol., 2022
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7XTY
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![BU of 7xty by Molmil](/molmil-images/mine/7xty) | Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide | Descriptor: | APC-peptide, Tyrosine-protein phosphatase non-receptor type 13 | Authors: | Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L. | Deposit date: | 2022-05-18 | Release date: | 2023-05-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer to be published
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7V7L
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![BU of 7v7l by Molmil](/molmil-images/mine/7v7l) | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | Authors: | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | Deposit date: | 2021-08-21 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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7V7W
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![BU of 7v7w by Molmil](/molmil-images/mine/7v7w) | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) | Descriptor: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | Authors: | Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D. | Deposit date: | 2021-08-21 | Release date: | 2022-05-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
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3B7J
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![BU of 3b7j by Molmil](/molmil-images/mine/3b7j) | Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 5-hydroxynaphthalene-1,4-dione, BENZAMIDINE, ... | Authors: | Zhang, L, Kong, Y.H, Wu, D, Shen, X, Jiang, H.L. | Deposit date: | 2007-10-31 | Release date: | 2008-09-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization ACTA PHARMACOL.SIN., 29, 2008
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7XC5
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![BU of 7xc5 by Molmil](/molmil-images/mine/7xc5) | Crystal structure of the ANK domain of CLPB | Descriptor: | Isoform 2 of Caseinolytic peptidase B protein homolog | Authors: | Liu, Y, Wu, D, Lu, G, Gao, N, Lin, J. | Deposit date: | 2022-03-23 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization. Plos Biol., 21, 2023
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