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PDB: 197 件
7XI4
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Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA
分子名称: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), ...
著者Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L.
登録日2022-04-12
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (4.707 Å)
主引用文献Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
7XHV
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BU of 7xhv by Molmil
Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA
分子名称: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ...
著者Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L.
登録日2022-04-10
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.996 Å)
主引用文献Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8JSW
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Human VMAT2 complex with serotonin
分子名称: SEROTONIN, Synaptic vesicular amine transporter
著者Jiang, D.H, Wu, D.
登録日2023-06-20
公開日2023-11-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8JTA
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BU of 8jta by Molmil
Human VMAT2 complex with tetrabenazine
分子名称: Synaptic vesicular amine transporter, tetrabenazine
著者Jiang, D.H, Wu, D.
登録日2023-06-21
公開日2023-11-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
8JT9
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BU of 8jt9 by Molmil
Human VMAT2 complex with ketanserin
分子名称: 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter
著者Jiang, D.H, Wu, D.
登録日2023-06-21
公開日2023-11-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
4NG2
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BU of 4ng2 by Molmil
Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa
分子名称: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein LasR, Uncharacterized protein
著者Fan, H, Wu, D.H, Song, H.
登録日2013-11-01
公開日2013-12-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing
Proc.Natl.Acad.Sci.USA, 110, 2013
8JTC
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Human VMAT2 complex with reserpine
分子名称: Synaptic vesicular amine transporter, reserpine
著者Jiang, D.H, Wu, D.
登録日2023-06-21
公開日2023-11-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Transport and inhibition mechanisms of human VMAT2.
Nature, 626, 2024
7WD3
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BU of 7wd3 by Molmil
Cryo-EM structure of Drg1 hexamer treated with ATP and benzo-diazaborine
分子名称: 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2021-12-21
公開日2022-12-14
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
7WBB
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Cryo-EM structure of substrate engaged Drg1 hexamer
分子名称: ADENOSINE-5'-TRIPHOSPHATE, AFG2 isoform 1, substrate
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2021-12-16
公開日2022-12-28
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
8GQO
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Solution NMR structure of vaccinia virus protein A28: an entry-fusion complex component
分子名称: Envelope protein A28
著者Tsai, M.H, Wu, D.N, Tzou, D.L.M.
登録日2022-08-30
公開日2023-09-06
最終更新日2024-02-14
実験手法SOLUTION NMR
主引用文献Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations.
Plos Pathog., 19, 2023
5UAN
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BU of 5uan by Molmil
Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA
分子名称: (9cis)-retinoic acid, DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), ...
著者Chandra, V, Wu, D, Kim, Y, Rastinejad, F.
登録日2016-12-19
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.508 Å)
主引用文献The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Nat Commun, 8, 2017
7YKT
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BU of 7ykt by Molmil
Cryo-EM structure of Drg1 hexamer in helical state treated with ADP/AMPPNP/benzo-diazaborine
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2022-07-23
公開日2022-12-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
7YKL
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Cryo-EM structure of Drg1 hexamer treated with AMPPNP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2022-07-22
公開日2022-12-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (5.6 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
7YKK
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BU of 7ykk by Molmil
Cryo-EM structure of Drg1 hexamer treated with ADP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATPase family gene 2 protein
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2022-07-22
公開日2022-12-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
7YKZ
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BU of 7ykz by Molmil
Cryo-EM structure of Drg1 hexamer in the planar state treated with ADP/AMPPNP/Diazaborine
分子名称: 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Ma, C.Y, Wu, D.M, Chen, Q, Gao, N.
登録日2022-07-25
公開日2022-12-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
Nat Commun, 13, 2022
7XYO
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BU of 7xyo by Molmil
Crystal Structure of a M61 aminopeptidase family member from Myxococcus fulvus
分子名称: Aminopeptidase M61, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ...
著者Chen, X, Wang, X, Huo, L, Wu, D.
登録日2022-06-02
公開日2023-06-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity.
J.Am.Chem.Soc., 145, 2023
7W80
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BU of 7w80 by Molmil
Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan
分子名称: 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Ren, X, Diao, X, Zhuang, J, Wu, D.
登録日2021-12-07
公開日2022-09-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.754 Å)
主引用文献Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan.
Mol.Pharmacol., 2022
7XTY
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BU of 7xty by Molmil
Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide
分子名称: APC-peptide, Tyrosine-protein phosphatase non-receptor type 13
著者Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L.
登録日2022-05-18
公開日2023-05-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer
to be published
7V7L
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BU of 7v7l by Molmil
Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex
分子名称: Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha
著者Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D.
登録日2021-08-21
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
7V7W
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BU of 7v7w by Molmil
Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA)
分子名称: (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha
著者Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D.
登録日2021-08-21
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.507 Å)
主引用文献Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
3B7J
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Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone
分子名称: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 5-hydroxynaphthalene-1,4-dione, BENZAMIDINE, ...
著者Zhang, L, Kong, Y.H, Wu, D, Shen, X, Jiang, H.L.
登録日2007-10-31
公開日2008-09-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization
ACTA PHARMACOL.SIN., 29, 2008
7XC5
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Crystal structure of the ANK domain of CLPB
分子名称: Isoform 2 of Caseinolytic peptidase B protein homolog
著者Liu, Y, Wu, D, Lu, G, Gao, N, Lin, J.
登録日2022-03-23
公開日2023-01-18
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.
Plos Biol., 21, 2023

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