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PDB: 50 results

6Q9K
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BU of 6q9k by Molmil
Crystal structure of reduced Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF S96M bound to NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Wohlwend, D, Gerhardt, S, Gnandt, E, Friedrich, T.
Deposit date:2018-12-18
Release date:2019-06-26
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.
Nat Commun, 10, 2019
5D3J
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BU of 5d3j by Molmil
First bromodomain of BRD4 bound to inhibitor XD33
Descriptor: 4-acetyl-N-[3-(diethylsulfamoyl)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3R
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BU of 5d3r by Molmil
First bromodomain of BRD4 bound to inhibitor XD42
Descriptor: 4-acetyl-N-[3-(azepan-1-ylsulfonyl)phenyl]-5-methyl-3-propyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3H
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BU of 5d3h by Molmil
First bromodomain of BRD4 bound to inhibitor XD29
Descriptor: Bromodomain-containing protein 4, N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-4-(hydroxyacetyl)-5-methyl-1H-pyrrole-2-carboxamide
Authors:Wohlwend, D, Huegle, M, Weitzel, G.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3L
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BU of 5d3l by Molmil
First bromodomain of BRD4 bound to inhibitor XD35
Descriptor: 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxy-4-methylphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3N
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BU of 5d3n by Molmil
First bromodomain of BRD4 bound to inhibitor XD40
Descriptor: 4-acetyl-3-ethyl-5-methyl-N-[2-methyl-5-(methylsulfamoyl)phenyl]-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
9FII
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BU of 9fii by Molmil
Crystal Structure of oxidized NuoEF variant E222K(NuoF) from Aquifex aeolicus
Descriptor: CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S.
Deposit date:2024-05-29
Release date:2024-07-17
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
9FIF
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BU of 9fif by Molmil
Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic conditions
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S.
Deposit date:2024-05-29
Release date:2024-07-17
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
9FIH
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BU of 9fih by Molmil
Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic conditions after 10 min soaking
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S.
Deposit date:2024-05-29
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
9FIJ
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BU of 9fij by Molmil
Crystal Structure of reduced NuoEF variant E222K(NuoF) from Aquifex aeolicus
Descriptor: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S.
Deposit date:2024-05-29
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
9FIL
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BU of 9fil by Molmil
Crystal Structure of reduced NuoEF variant E222K(NuoF) from Aquifex aeolicus bound to NAD+
Descriptor: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S.
Deposit date:2024-05-29
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
5D24
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BU of 5d24 by Molmil
First bromodomain of BRD4 bound to inhibitor XD26
Descriptor: 1,2-ETHANEDIOL, 4-acetyl-N-[3-(2-amino-2-oxoethoxy)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
Authors:Wohlwend, D, Huegle, M, Gerhardt, S.
Deposit date:2015-08-05
Release date:2016-01-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3S
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BU of 5d3s by Molmil
First bromodomain of BRD4 bound to inhibitor XD44
Descriptor: (R,R)-2,3-BUTANEDIOL, 4-acetyl-3-ethyl-N-[4-fluoro-3-(morpholin-4-ylsulfonyl)phenyl]-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D26
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BU of 5d26 by Molmil
First bromodomain of BRD4 bound to inhibitor XD28
Descriptor: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-05
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D25
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BU of 5d25 by Molmil
First bromodomain of BRD4 bound to inhibitor XD27
Descriptor: (R,R)-2,3-BUTANEDIOL, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
Authors:Wohlwend, D, Huegle, M, Gerhardt, S.
Deposit date:2015-08-05
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3P
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BU of 5d3p by Molmil
First bromodomain of BRD4 bound to inhibitor XD41
Descriptor: 1-[(4-acetyl-3-ethyl-5-methyl-1H-pyrrol-2-yl)carbonyl]-N-methyl-1H-indole-6-sulfonamide, Bromodomain-containing protein 4, NICKEL (II) ION
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5D3T
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BU of 5d3t by Molmil
First bromodomain of BRD4 bound to inhibitor XD47
Descriptor: 1,2-ETHANEDIOL, 4-acetyl-N-(3-carbamoylbenzyl)-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ...
Authors:Wohlwend, D, Huegle, M.
Deposit date:2015-08-06
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).
J.Med.Chem., 59, 2016
5AFW
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BU of 5afw by Molmil
Assembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, ...
Authors:Metzger, E, Willmann, D, McMillan, J, Petroll, K, Metzger, P, Gerhardt, S, vonMaessenhausen, A, Schott, A.K, Espejo, A, Eberlin, A, Wohlwend, D, Schuele, K.M, Schleicher, M, Perner, S, Bedford, M.T, Dengjel, J, Flaig, R, Einsle, O, Schuele, R.
Deposit date:2015-01-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Nat.Struct.Mol.Biol., 23, 2016
7OSE
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BU of 7ose by Molmil
cytochrome bd-II type oxidase with bound aurachin D
Descriptor: Aurachin D, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Cytochrome bd-II ubiquinol oxidase subunit 1, ...
Authors:Grauel, A, Kaegi, J, Rasmussen, T, Wohlwend, D, Boettcher, B, Friedrich, T.
Deposit date:2021-06-08
Release date:2021-11-17
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D.
Nat Commun, 12, 2021
5NU3
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BU of 5nu3 by Molmil
Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP
Descriptor: (R,R)-2,3-BUTANEDIOL, CREB-binding protein, SULFATE ION, ...
Authors:Huegle, M, Wohlwend, D.
Deposit date:2017-04-28
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NU5
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BU of 5nu5 by Molmil
Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP
Descriptor: 1,2-ETHANEDIOL, Histone acetyltransferase p300, ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
Authors:Huegle, M, Wohlwend, D.
Deposit date:2017-04-28
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NRW
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BU of 5nrw by Molmil
Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4
Descriptor: 1,2-ETHANEDIOL, 4-ethanoyl-3-ethyl-5-methyl-~{N}-(naphthalen-1-ylmethyl)-1~{H}-pyrrole-2-carboxamide, CREB-binding protein
Authors:Huegle, M, Wohlwend, D.
Deposit date:2017-04-25
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5LPM
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BU of 5lpm by Molmil
Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d
Descriptor: ACETATE ION, Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide
Authors:Huegle, M, Wohlwend, D, Gerhardt, S.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5LPJ
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BU of 5lpj by Molmil
Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM1
Descriptor: CREB-binding protein, ~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
Authors:Huegle, M, Wohlwend, D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
5LPK
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BU of 5lpk by Molmil
Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1
Descriptor: 1,2-ETHANEDIOL, Histone acetyltransferase p300, SULFATE ION, ...
Authors:Huegle, M, Wohlwend, D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
Angew. Chem. Int. Ed. Engl., 56, 2017
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