5NU5

Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP

Summary for 5NU5

• Entry DOI: 10.2210/pdb5nu5/pdb
• Descriptor: Histone acetyltransferase p300, ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, protein-inhibitor complex, epigenetics, ep300, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q09472
• Total number of polymer chains: 2
• Total formula weight: 28696.75

Authors

Huegle, M.,Wohlwend, D. (deposition date: 2017-04-28, release date: 2017-08-16, Last modification date: 2024-01-17)

• Primary citation: Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D.; Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.; Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017; PubMed: 28766825; DOI: 10.1002/anie.201705516

Experimental method

X-RAY DIFFRACTION (1.6 Å)