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5NU5

Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 99E A 1201
ChainResidue
ALEU1073
AHOH1311
AHOH1346
APRO1074
AGLN1077
AVAL1079
AILE1086
ATYR1131
AASN1132
AARG1137
AHOH1309

site_idAC2
Number of Residues1
Detailsbinding site for residue EDO A 1202
ChainResidue
AARG1076

site_idAC3
Number of Residues1
Detailsbinding site for residue EDO A 1203
ChainResidue
BASP1154

site_idAC4
Number of Residues8
Detailsbinding site for residue EDO A 1204
ChainResidue
AALA1057
APRO1060
AVAL1156
AHOH1302
AHOH1345
AHOH1352
AHOH1400
AHOH1420

site_idAC5
Number of Residues12
Detailsbinding site for residue 99E B 1201
ChainResidue
BLEU1073
BPRO1074
BGLN1077
BVAL1079
BLEU1084
BILE1086
BTYR1131
BASN1132
BARG1137
BHOH1303
BHOH1322
BHOH1344

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO B 1202
ChainResidue
BLYS1105
BGLN1110
BGLN1116
BHOH1349

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY
ChainResidueDetails
ASER1072-TYR1131

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PDB entries from 2024-11-13

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