2QA5
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1F5N
| HUMAN GUANYLATE BINDING PROTEIN-1 IN COMPLEX WITH THE GTP ANALOGUE, GMPPNP. | 分子名称: | INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Prakash, B, Renault, L, Praefcke, G.J.K, Herrmann, C, Wittinghofer, A. | 登録日 | 2000-06-15 | 公開日 | 2000-09-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism. EMBO J., 19, 2000
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4GOK
| The Crystal structure of Arl2GppNHp in complex with UNC119a | 分子名称: | ADP-ribosylation factor-like protein 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | 登録日 | 2012-08-20 | 公開日 | 2012-09-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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4JV6
| The crystal structure of PDE6D in complex to inhibitor-1 | 分子名称: | 1-benzyl-2-phenyl-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H. | 登録日 | 2013-03-25 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497, 2013
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4JV8
| The crystal structure of PDE6D in complex with rac-S1 | 分子名称: | (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H. | 登録日 | 2013-03-25 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497, 2013
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4GOJ
| The Crystal Structure of full length Arl3GppNHp in complex with UNC119a | 分子名称: | ADP-ribosylation factor-like protein 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | 登録日 | 2012-08-20 | 公開日 | 2012-09-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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4JVB
| Crystal structure of PDE6D in complex with the inhibitor rac-2 | 分子名称: | 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H. | 登録日 | 2013-03-25 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497, 2013
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4JVF
| The Crystal structure of PDE6D in complex with the inhibitor (s)-5 | 分子名称: | (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H. | 登録日 | 2013-03-25 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497, 2013
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1JAH
| H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM | 分子名称: | C-HA-RAS, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | 著者 | Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A. | 登録日 | 1996-12-15 | 公開日 | 1997-07-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J.Mol.Biol., 266, 1997
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1JAI
| H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE | 分子名称: | C-HA-RAS, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | 著者 | Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A. | 登録日 | 1996-12-15 | 公開日 | 1997-07-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J.Mol.Biol., 266, 1997
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1O9F
| Structural view of a fungal toxin acting on a 14-3-3 regulatory complex | 分子名称: | 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE | 著者 | Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. | 登録日 | 2002-12-12 | 公開日 | 2003-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
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1GNR
| X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP | 分子名称: | C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION | 著者 | Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. | 登録日 | 1995-05-11 | 公開日 | 1995-07-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
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1O9D
| Structural view of a fungal toxin acting on a 14-3-3 regulatory complex | 分子名称: | 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE | 著者 | Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. | 登録日 | 2002-12-12 | 公開日 | 2003-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
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1KSH
| Complex of Arl2 and PDE delta, Crystal Form 2 (native) | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Hanzal-Bayer, M, Renault, L, Roversi, P, Wittinghofer, A, Hillig, R.C. | 登録日 | 2002-01-13 | 公開日 | 2002-05-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J., 21, 2002
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1KSJ
| Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet) | 分子名称: | BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Hanzal-Bayer, M, Renault, L, Roversi, P, Wittinghofer, A, Hillig, R.C. | 登録日 | 2002-01-13 | 公開日 | 2002-05-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The complex of Arl2-GTP and PDE delta: from structure to function EMBO J., 21, 2002
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1KSG
| Complex of Arl2 and PDE delta, Crystal Form 1 | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT, ... | 著者 | Hanzal-Bayer, M, Renault, L, Roversi, P, Wittinghofer, A, Hillig, R.C. | 登録日 | 2002-01-13 | 公開日 | 2002-05-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J., 21, 2002
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1XZP
| Structure of the GTP-binding protein TrmE from Thermotoga maritima | 分子名称: | Probable tRNA modification GTPase trmE, SULFATE ION | 著者 | Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A. | 登録日 | 2004-11-12 | 公開日 | 2005-01-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of the TrmE GTP-binding protein and its implications for tRNA modification Embo J., 24, 2005
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1XZQ
| Structure of the GTP-binding protein TrmE from Thermotoga maritima complexed with 5-formyl-THF | 分子名称: | N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, Probable tRNA modification GTPase trmE | 著者 | Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A. | 登録日 | 2004-11-12 | 公開日 | 2005-01-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The structure of the TrmE GTP-binding protein and its implications for tRNA modification Embo J., 24, 2005
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1V9D
| Crystal structure of the core FH2 domain of mouse mDia1 | 分子名称: | Diaphanous protein homolog 1, SULFATE ION | 著者 | Shimada, A, Nyitrai, M, Vetter, I.R, Kuhlmann, D, Bugyi, B, Narumiya, S, Geeves, M.A, Wittinghofer, A. | 登録日 | 2004-01-24 | 公開日 | 2004-03-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol.Cell, 13, 2004
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1USD
| human VASP tetramerisation domain L352M | 分子名称: | VASODILATOR-STIMULATED PHOSPHOPROTEIN | 著者 | Kuhnel, K, Jarchau, T, Wolf, E, Schlichting, I, Walter, U, Wittinghofer, A, Strelkov, S.V. | 登録日 | 2003-11-21 | 公開日 | 2004-11-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Vasp Tetramerization Domain is a Right-Handed Coiled Coil Based on a 15-Residue Repeat Proc.Natl.Acad.Sci.USA, 101, 2004
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3E6Y
| Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A | 分子名称: | 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... | 著者 | Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. | 登録日 | 2008-08-17 | 公開日 | 2009-03-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
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1O7F
| CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2 | 分子名称: | CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR | 著者 | Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A. | 登録日 | 2002-11-04 | 公開日 | 2002-11-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and Regulation of the Camp-Binding Domains of Epac2 Nat.Struct.Biol., 10, 2002
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1O9C
| Structural view of a fungal toxin acting on a 14-3-3 regulatory complex | 分子名称: | 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION | 著者 | Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. | 登録日 | 2002-12-12 | 公開日 | 2003-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
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1O9E
| Structural view of a fungal toxin acting on a 14-3-3 regulatory complex | 分子名称: | 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN | 著者 | Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. | 登録日 | 2002-12-12 | 公開日 | 2003-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
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1YE8
| Crystal Structure of THEP1 from the hyperthermophile Aquifex aeolicus | 分子名称: | Hypothetical UPF0334 kinase-like protein AQ_1292, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Rossbach, M, Daumke, O, Klinger, C, Wittinghofer, A, Kaufmann, M. | 登録日 | 2004-12-28 | 公開日 | 2005-03-29 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold BMC Struct.Biol., 5, 2005
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