2LP8
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![BU of 2lp8 by Molmil](/molmil-images/mine/2lp8) | SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL | Descriptor: | 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 | Authors: | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | Deposit date: | 2012-02-03 | Release date: | 2012-04-18 | Last modified: | 2021-08-18 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
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2LPC
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![BU of 2lpc by Molmil](/molmil-images/mine/2lpc) | NMR STRUCTURE of Bcl-XL | Descriptor: | Bcl-2-like protein 1 | Authors: | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | Deposit date: | 2012-02-09 | Release date: | 2012-03-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
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2JOL
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![BU of 2jol by Molmil](/molmil-images/mine/2jol) | Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | Descriptor: | Putative G-nucleotide exchange factor | Authors: | Wu, H, Upadhyay, A, Williams, C, Galyov, E.E, van den Elsen, J.M.H, Bagby, S. | Deposit date: | 2007-03-14 | Release date: | 2007-03-27 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42 Biochem.J., 411, 2008
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2M68
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![BU of 2m68 by Molmil](/molmil-images/mine/2m68) | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) | Descriptor: | Insulin-like growth factor 2 receptor variant | Authors: | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | Deposit date: | 2013-03-27 | Release date: | 2014-10-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
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2K0X
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![BU of 2k0x by Molmil](/molmil-images/mine/2k0x) | |
2JOK
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![BU of 2jok by Molmil](/molmil-images/mine/2jok) | NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | Descriptor: | Putative G-nucleotide exchange factor | Authors: | Wu, H, Upadhyay, A, Williams, C, Galyov, E.E, van den Elsen, J.M.H, Bagby, S. | Deposit date: | 2007-03-14 | Release date: | 2007-09-18 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42 Biochem.J., 411, 2008
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2KGD
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![BU of 2kgd by Molmil](/molmil-images/mine/2kgd) | NMR Solution Structures of 3-oxo-butyl-ACP, an intermediate mimic from the actinorhodin polyketide synthase in Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(3-oxobutyl)sulfanyl]ethyl}-beta-alaninamide | Authors: | Crump, M.P, Evans, S.E, Williams, C. | Deposit date: | 2009-03-08 | Release date: | 2009-04-14 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
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2KG8
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![BU of 2kg8 by Molmil](/molmil-images/mine/2kg8) | NMR Solution Structures of malonyl ACP from the actinorhodin polyketide synthase in Streptomyces coelicolor | Descriptor: | 3-{[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-3-oxopropanoic acid, Actinorhodin polyketide synthase acyl carrier protein | Authors: | Crump, M.P, Evans, S.E, Williams, C, Eliza, P. | Deposit date: | 2009-03-06 | Release date: | 2009-04-14 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
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2KGA
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![BU of 2kga by Molmil](/molmil-images/mine/2kga) | |
2KR5
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![BU of 2kr5 by Molmil](/molmil-images/mine/2kr5) | Solution Structure of an Acyl Carrier Protein Domain from Fungal Type I Polyketide Synthase | Descriptor: | 4'-PHOSPHOPANTETHEINE, Aflatoxin biosynthesis polyketide synthase | Authors: | Wattana-amorn, P, Williams, C, Ploskon, E, Cox, R.J, Simpson, T.J, Crosby, J, Crump, M.P. | Deposit date: | 2009-12-03 | Release date: | 2010-03-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase. Biochemistry, 49, 2010
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2M6T
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![BU of 2m6t by Molmil](/molmil-images/mine/2m6t) | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R | Descriptor: | Insulin-like growth factor 2 receptor variant | Authors: | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | Deposit date: | 2013-04-09 | Release date: | 2014-10-15 | Last modified: | 2016-06-01 | Method: | SOLUTION NMR | Cite: | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
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2KG9
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![BU of 2kg9 by Molmil](/molmil-images/mine/2kg9) | NMR Solution Structures of butyryl-ACP (a non-polar, non pathway intermediate) from the actinorhodin polyketide synthase in Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, THIOBUTYRIC ACID S-{2-[3-(2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTYRYLAMINO)-PROPIONYLAMINO]-ETHYL} ESTER | Authors: | Crump, M.P, Evans, S.E, Williams, C. | Deposit date: | 2009-03-07 | Release date: | 2009-04-14 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
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2KGE
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![BU of 2kge by Molmil](/molmil-images/mine/2kge) | NMR Solution Structures of 3,5-dioxohexyl ACP (a triketide mimic) from the actinorhodin polyketide synthase in Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, N-{2-[(3,5-dioxohexyl)sulfanyl]ethyl}-N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide | Authors: | Crump, M.P, Evans, S.E, Williams, C. | Deposit date: | 2009-03-08 | Release date: | 2009-04-14 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
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2KGC
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![BU of 2kgc by Molmil](/molmil-images/mine/2kgc) | |
4C26
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![BU of 4c26 by Molmil](/molmil-images/mine/4c26) | Solution NMR structure of the HicA toxin from Burkholderia pseudomallei | Descriptor: | HICA | Authors: | Butt, A, Higman, V.A, Williams, C, Crump, M.P, Hemsley, C, Harmer, N, Titball, R.W. | Deposit date: | 2013-08-16 | Release date: | 2014-04-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Hica Toxin from Burkholderia Pseudomallei Has a Role in Persister Cell Formation. Biochem.J., 459, 2014
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5NKZ
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![BU of 5nkz by Molmil](/molmil-images/mine/5nkz) | Crystal structure of H. polymorpha ubiquitin conjugating enzyme Pex4p in complex with soluble domain of Pex22p | Descriptor: | Peroxin 22, Ubiquitin-conjugating enzyme E2-21 kDa | Authors: | Danda, N, Lunev, S, Ali, A, Groves, M.R, Williams, C. | Deposit date: | 2017-04-03 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex. Biochem. Biophys. Res. Commun., 496, 2018
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5NL8
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![BU of 5nl8 by Molmil](/molmil-images/mine/5nl8) | Pex4 of Hansenula Polymorpha | Descriptor: | Ubiquitin-conjugating enzyme E2-21 kDa | Authors: | Groves, M, Williams, C. | Deposit date: | 2017-04-04 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex. Biochem. Biophys. Res. Commun., 496, 2018
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4CRP
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![BU of 4crp by Molmil](/molmil-images/mine/4crp) | Solution structure of a TrkAIg2 domain construct for use in drug discovery | Descriptor: | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | Authors: | Shoemark, D.K, Fahey, M, Williams, C, Sessions, R.B, Crump, M.P, Allen-Birt, S.J. | Deposit date: | 2014-02-28 | Release date: | 2015-01-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery J.Med.Chem., 58, 2015
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3Q6G
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![BU of 3q6g by Molmil](/molmil-images/mine/3q6g) | Crystal structure of Fab of rhesus mAb 2.5B specific for quaternary neutralizing epitope of HIV-1 gp120 | Descriptor: | Heavy chain of Fab of rhesus mAb 2.5B, Light chain of Fab of rhesus mAb 2.5B | Authors: | Spurrier, B, Sampson, J, Totrov, M, Li, H, O'Neal, T, William, C, Robinson, J, Gorny, M.K, Zolla-Pazner, S, Kong, X.P. | Deposit date: | 2010-12-31 | Release date: | 2011-05-25 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120. Structure, 19, 2011
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3Q6F
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![BU of 3q6f by Molmil](/molmil-images/mine/3q6f) | Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 | Descriptor: | DI(HYDROXYETHYL)ETHER, Heavy chain of Fab of human mAb 2909, Light chain of Fab of human mAb 2909 | Authors: | Spurrier, B, Sampson, J, Totrov, M, Li, H, O'Neal, T, William, C, Robinson, J, Gorny, M.K, Zolla-Pazner, S, Kong, X.P. | Deposit date: | 2010-12-31 | Release date: | 2011-05-25 | Last modified: | 2011-10-12 | Method: | X-RAY DIFFRACTION (3.192 Å) | Cite: | Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120. Structure, 19, 2011
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