4CRP

Solution structure of a TrkAIg2 domain construct for use in drug discovery

Summary for 4CRP

• Entry DOI: 10.2210/pdb4crp/pdb
• NMR Information: BMRB: 19824
• Descriptor: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (1 entity in total)
• Functional Keywords: transferase, trkaig2, nmr construct, pain, alzheimers
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 11792.07

Authors

Shoemark, D.K.,Fahey, M.,Williams, C.,Sessions, R.B.,Crump, M.P.,Allen-Birt, S.J. (deposition date: 2014-02-28, release date: 2015-01-14, Last modification date: 2023-06-14)

• Primary citation: Allen, S.J.,Watson, J.J.,Shoemark, D.K.,Barua, N.U.,Patel, N.K.; Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery; J.Med.Chem., 58:767-, 2015; PubMed: 25454499; DOI: 10.1021/JM501307E

Experimental method

SOLUTION NMR