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PDB: 107 件
3DBS
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BU of 3dbs by Molmil
Structure of PI3K gamma in complex with GDC0941
分子名称: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Wiesmann, C, Ultsch, M.
登録日2008-06-02
公開日2008-06-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
J.Med.Chem., 51, 2008
3PBG
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BU of 3pbg by Molmil
6-PHOSPHO-BETA-GALACTOSIDASE FORM-C
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
1FLT
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BU of 1flt by Molmil
VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, De Vos, A.M.
登録日1997-11-20
公開日1999-01-13
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
2ICC
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BU of 2icc by Molmil
Extracellular Domain of CRIg
分子名称: V-set and immunoglobulin domain-containing protein 4
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
6FFS
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BU of 6ffs by Molmil
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
分子名称: 3C Protease, SULFATE ION, ~{N}-[(2~{S},5~{S},14~{S})-2-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-9-methyl-3,8,15-tris(oxidanylidene)-1,4,9-triazacyclopentadec-14-yl]-5-methyl-1,2-oxazole-3-carboxamide
著者Wiesmann, C, Farady, C.
登録日2018-01-09
公開日2018-02-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6FFN
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Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
分子名称: 3C protease, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Wiesmann, C, Farady, C.
登録日2018-01-08
公開日2018-02-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
1QTY
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BU of 1qty by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, de Vos, A.M.
登録日1999-06-29
公開日2000-01-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
3GRW
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FGFR3 in complex with a Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
著者Wiesmann, C.
登録日2009-03-26
公開日2009-05-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
J.Clin.Invest., 119, 2009
2ICE
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BU of 2ice by Molmil
CRIg bound to C3c
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
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CRIg bound to C3b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
1T4J
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Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Protein-tyrosine phosphatase, non-receptor type 1
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-29
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
2PBG
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6-PHOSPHO-BETA-D-GALACTOSIDASE FORM-B
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
1PBG
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BU of 1pbg by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF 6-PHOSPHO-BETA GALACTOSIDASE FROM LACTOCOCCUS LACTIS
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1995-09-14
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The three-dimensional structure of 6-phospho-beta-galactosidase from Lactococcus lactis.
Structure, 3, 1995
4PBG
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BU of 4pbg by Molmil
6-PHOSPHO-BETA-GALACTOSIDASE FORM-CST
分子名称: 6-O-phosphono-beta-D-galactopyranose, 6-PHOSPHO-BETA-D-GALACTOSIDASE
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
2PND
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BU of 2pnd by Molmil
Structure or murine CRIg
分子名称: V-set and immunoglobulin domain containing 4
著者Wiesmann, C.
登録日2007-04-24
公開日2007-05-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis.
J.Exp.Med., 204, 2007
3H10
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BU of 3h10 by Molmil
Aurora A inhibitor complex
分子名称: 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
3H0Y
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Aurora A in complex with a bisanilinopyrimidine
分子名称: 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
3G6J
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C3b in complex with a C3b specific Fab
分子名称: CALCIUM ION, Complement C3 alpha chain, Complement C3 beta chain, ...
著者Wiesmann, C.
登録日2009-02-06
公開日2009-03-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
1T49
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Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, MAGNESIUM ION, Protein-tyrosine phosphatase, ...
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-28
公開日2004-07-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B.
Nat.Struct.Mol.Biol., 11, 2004
3H0Z
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Aurora A in complex with a bisanilinopyrimidine
分子名称: 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide, Serine/threonine-protein kinase 6
著者Wiesmann, C, Ultsch, M.H, Cochran, A.G.
登録日2009-04-10
公開日2009-07-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
J.Med.Chem., 52, 2009
1T48
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Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
分子名称: 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID DIMETHYLAMIDE, Protein-tyrosine phosphatase, non-receptor type 1
著者Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Erlanson, D.A, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K.
登録日2004-04-28
公開日2004-07-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
1WWW
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NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR
分子名称: PROTEIN (NERVE GROWTH FACTOR), PROTEIN (TRKA RECEPTOR)
著者Wiesmann, C, Ultsch, M.H, De Vos, A.M.
登録日1999-03-12
公開日1999-09-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Nature, 401, 1999
1WWB
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LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR
分子名称: PROTEIN (Brain Derived Neurotrophic Factor Receptor TrkB)
著者Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M.
登録日1999-05-03
公開日1999-07-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
2FJG
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Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJH
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Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006

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