4B3H
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3ZWB
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![BU of 3zwb by Molmil](/molmil-images/mine/3zwb) | CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 2TRANS-HEXENOYL-COA | Descriptor: | (2E)-Hexenoyl-CoA, GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, ... | Authors: | Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2011-07-28 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa. FEBS J., 280, 2013
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3ZWC
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![BU of 3zwc by Molmil](/molmil-images/mine/3zwc) | CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-DECANOYL-COA | Descriptor: | (S)-3-HYDROXYDECANOYL-COA, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2011-07-28 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa. FEBS J., 280, 2013
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3ZW8
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![BU of 3zw8 by Molmil](/molmil-images/mine/3zw8) | Crystal Structure Of Rat Peroxisomal Multifunctional Enzyme Type 1 (rpMFE1) In Apo Form | Descriptor: | GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, SULFATE ION | Authors: | Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2011-07-28 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa. FEBS J., 280, 2013
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8PF8
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![BU of 8pf8 by Molmil](/molmil-images/mine/8pf8) | Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-72 | Descriptor: | (2~{R})-3-bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boranyloxypropane-1,2-diol, 3-hydroxyacyl-CoA dehydrogenase, GLYCEROL, ... | Authors: | Dalwani, S, Wierenga, R.K, Venkatesan, R. | Deposit date: | 2023-06-15 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystallographic fragment binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate channeling path between them Biorxiv, 2024
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3ZWA
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![BU of 3zwa by Molmil](/molmil-images/mine/3zwa) | CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-HEXANOYL-COA | Descriptor: | (S)-3-Hydroxyhexanoyl-CoA, GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, ... | Authors: | Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2011-07-28 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa. FEBS J., 280, 2013
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1TTJ
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1QDS
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![BU of 1qds by Molmil](/molmil-images/mine/1qds) | SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM) | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Lambeir, A.M, Backmann, J, Ruiz-Sanz, J, Filimonov, V, Nielsen, J.E, Vriend, G, Kursula, I, Norledge, B.V, Wierenga, R.K. | Deposit date: | 1999-07-10 | Release date: | 2000-12-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase. Eur.J.Biochem., 267, 2000
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1SHG
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![BU of 1shg by Molmil](/molmil-images/mine/1shg) | CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 (SH3) DOMAIN | Descriptor: | ALPHA-SPECTRIN SH3 DOMAIN | Authors: | Noble, M, Pauptit, R, Musacchio, A, Saraste, M, Wierenga, R.K. | Deposit date: | 1993-05-19 | Release date: | 1993-10-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a Src-homology 3 (SH3) domain. Nature, 359, 1992
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1AFW
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1WL4
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![BU of 1wl4 by Molmil](/molmil-images/mine/1wl4) | Human cytosolic acetoacetyl-CoA thiolase complexed with CoA | Descriptor: | COENZYME A, GLYCEROL, SULFATE ION, ... | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | Deposit date: | 2004-06-20 | Release date: | 2005-03-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I J.Mol.Biol., 347, 2005
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1B9B
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![BU of 1b9b by Molmil](/molmil-images/mine/1b9b) | TRIOSEPHOSPHATE ISOMERASE OF THERMOTOGA MARITIMA | Descriptor: | PROTEIN (TRIOSEPHOSPHATE ISOMERASE), SULFATE ION | Authors: | Maes, D, Wierenga, R.K. | Deposit date: | 1999-02-09 | Release date: | 2000-01-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures. Proteins, 37, 1999
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1TJC
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![BU of 1tjc by Molmil](/molmil-images/mine/1tjc) | Crystal structure of peptide-substrate-binding domain of human type I collagen prolyl 4-hydroxylase | Descriptor: | Prolyl 4-hydroxylase alpha-1 subunit | Authors: | Pekkala, M, Hieta, R, Bergmann, U, Kivirikko, K.I, Wierenga, R.K, Myllyharju, J. | Deposit date: | 2004-06-04 | Release date: | 2004-10-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Peptide-Substrate-binding Domain of Collagen Prolyl 4-Hydroxylases Is a Tetratricopeptide Repeat Domain with Functional Aromatic Residues. J.Biol.Chem., 279, 2004
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1SQ7
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![BU of 1sq7 by Molmil](/molmil-images/mine/1sq7) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-18 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW0
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![BU of 1sw0 by Molmil](/molmil-images/mine/1sw0) | Triosephosphate isomerase from Gallus gallus, loop 6 hinge mutant K174L, T175W | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW3
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![BU of 1sw3 by Molmil](/molmil-images/mine/1sw3) | Triosephosphate isomerase from Gallus gallus, loop 6 mutant T175V | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SU5
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![BU of 1su5 by Molmil](/molmil-images/mine/1su5) | Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, GLYCEROL, SULFATE ION, ... | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-26 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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1SW7
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![BU of 1sw7 by Molmil](/molmil-images/mine/1sw7) | Triosephosphate isomerase from Gallus gallus, loop 6 mutant K174N, T175S, A176S | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kursula, I, Salin, M, Sun, J, Norledge, B.V, Haapalainen, A.M, Sampson, N.S, Wierenga, R.K. | Deposit date: | 2004-03-30 | Release date: | 2004-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase Protein Eng.Des.Sel., 17, 2004
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3ZBL
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![BU of 3zbl by Molmil](/molmil-images/mine/3zbl) | Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, CHLORIDE ION, ... | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | Deposit date: | 2012-11-10 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
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1WL5
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![BU of 1wl5 by Molmil](/molmil-images/mine/1wl5) | Human cytosolic acetoacetyl-CoA thiolase | Descriptor: | GLYCEROL, SULFATE ION, acetyl-Coenzyme A acetyltransferase 2 | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | Deposit date: | 2004-06-20 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I J.Mol.Biol., 347, 2005
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3ZBG
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![BU of 3zbg by Molmil](/molmil-images/mine/3zbg) | Crystal structure of wild-type SCP2 thiolase from Leishmania mexicana at 1.85 A | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-KETOACYL-COA THIOLASE-LIKE PROTEIN, DIMETHYL SULFOXIDE | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | Deposit date: | 2012-11-09 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
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1OU6
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2J27
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![BU of 2j27 by Molmil](/molmil-images/mine/2j27) | The functional role of the conserved active site proline of triosephosphate isomerase. | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | Authors: | Casteleijn, M.G, Alahuhta, M, Groebel, K, El-Sayed, I, Augustyns, K, Lambeir, A.M, Neubauer, P, Wierenga, R.K. | Deposit date: | 2006-08-16 | Release date: | 2007-01-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase. Biochemistry, 45, 2006
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4B3I
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1GYR
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![BU of 1gyr by Molmil](/molmil-images/mine/1gyr) | Mutant form of enoyl thioester reductase from Candida tropicalis | Descriptor: | 2,4-DIENOYL-COA REDUCTASE, GLYCEROL, SULFATE ION | Authors: | Airenne, T.T, Torkko, J.M, Van Der Plas, S, Sormunen, R.T, Kastaniotis, A.J, Wierenga, R.K, Hiltunen, J.K. | Deposit date: | 2002-04-29 | Release date: | 2003-03-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Function Analysis of Enoyl Thioester Reductase Involved in Mitochondrial Maintenance J.Mol.Biol., 327, 2003
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