4ZWS
| |
1HD8
| |
1HW2
| FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ECHERICHIA COLI | 分子名称: | 5'-D(*CP*GP*AP*TP*CP*TP*GP*GP*TP*CP*CP*GP*AP*CP*CP*AP*GP*AP*TP*GP*CP*T)-3', 5'-D(*G*CP*AP*TP*CP*TP*GP*GP*TP*CP*GP*GP*AP*CP*CP*AP*GP*AP*TP*CP*GP*A)-3', FATTY ACID METABOLISM REGULATOR PROTEIN, ... | 著者 | Xu, Y, Heath, R.J, Li, Z, Rock, C.O, White, S.W. | 登録日 | 2001-01-09 | 公開日 | 2001-01-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J.Biol.Chem., 276, 2001
|
|
4ZWT
| |
1PKP
| |
5JLT
| The crystal structure of the bacteriophage T4 MotA C-terminal domain in complex with dsDNA reveals a novel protein-DNA recognition motif | 分子名称: | DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*TP*GP*CP*TP*TP*AP*AP*TP*AP*AP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*GP*AP*TP*TP*AP*TP*TP*AP*AP*GP*CP*AP*AP*AP*GP*CP*TP*TP*C)-3'), Middle transcription regulatory protein motA | 著者 | Cuypers, M.G, Robertson, R.M, Knipling, L, Hinton, D.M, White, S.W. | 登録日 | 2016-04-27 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | 主引用文献 | The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA. Nucleic Acids Res., 46, 2018
|
|
1PT9
| Crystal Structure Analysis of the DIII Component of Transhydrogenase with a Thio-Nicotinamide Nucleotide Analogue | 分子名称: | 7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, NAD(P) transhydrogenase, ... | 著者 | Singh, A, Venning, J.D, Quirk, P.G, van Boxel, G.I, Rodrigues, D.J, White, S.A, Jackson, J.B. | 登録日 | 2003-06-23 | 公開日 | 2003-10-07 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation J.Biol.Chem., 278, 2003
|
|
5VPX
| I38T mutant of 2009 H1N1 PA Endonuclease in complex with RO-7 | 分子名称: | 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-05-06 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
|
|
5VQN
| E119D mutant of 2009 H1N1 PA Endonuclease in complex with RO-7 | 分子名称: | 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-05-09 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
|
|
5EGA
| 2009 H1N1 PA endonuclease domain in complex with an N-acylhydrazone inhibitor | 分子名称: | 3,4,5-tris(oxidanyl)-~{N}-[(~{E})-[3,4,5-tris(oxidanyl)phenyl]methylideneamino]benzamide, MANGANESE (II) ION, Polymerase acidic protein | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-10-26 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes. Sci Rep, 6, 2016
|
|
5VPT
| 2009 H1N1 PA Endonuclease in complex with RO-7 | 分子名称: | 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-05-05 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
|
|
5VRJ
| 2009 H1N1 PA Endonuclease in complex with RO-7 and Magnesium | 分子名称: | 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione, MAGNESIUM ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-05-10 | 公開日 | 2018-04-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
|
|
6D88
| Tubulin-RB3_SLD-TTL in complex with compound 13f | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2018-04-26 | 公開日 | 2018-09-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.853 Å) | 主引用文献 | Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities. J. Med. Chem., 61, 2018
|
|
6B9I
| The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein loaded with 14-Methylhexadecanoic Acid (Anteiso C17:0) to 1.93 Angstrom resolution | 分子名称: | (14S)-14-methylhexadecanoic acid, Fatty acid Kinase (Fak) B1, GLYCEROL, ... | 著者 | Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O. | 登録日 | 2017-10-10 | 公開日 | 2018-10-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Acyl-chain selectivity and physiological roles ofStaphylococcus aureusfatty acid-binding proteins. J. Biol. Chem., 294, 2019
|
|
6CNG
| The X-ray crystal structure of the Streptococcus pneumoniae Fatty Acid Kinase (Fak) B3 protein loaded with linoleic acid to 1.47 Angstrom resolution | 分子名称: | ACETATE ION, Fatty Acid Kinase (Fak) B3 protein, GLYCEROL, ... | 著者 | Cuypers, M.G, Subramanian, C, White, S.W, Rock, C.O. | 登録日 | 2018-03-08 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | The X-ray crystal structure of the Streptococcus pneumoniae Fatty Acid Kinase (Fak) B3 protein loaded with linoleic acid to 1.47 Angstrom resolution To Be Published
|
|
5VP8
| I38T mutant of 2009 H1N1 PA Endonuclease | 分子名称: | 1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-05-04 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9, 2018
|
|
6ALW
| The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein loaded with 12-Methyl Myristic Acid (C15:0) to 1.63 Angstrom resolution | 分子名称: | (12R)-12-methyltetradecanoic acid, (12S)-12-methyltetradecanoic acid, EDD domain protein, ... | 著者 | Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O. | 登録日 | 2017-08-08 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Acyl-chain selectivity and physiological roles ofStaphylococcus aureusfatty acid-binding proteins. J. Biol. Chem., 294, 2019
|
|
5WB3
| Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10j (SRI-30026) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-06-27 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
|
|
5WFZ
| Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 8e (SRI-30049) | 分子名称: | 2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-07-13 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
|
|
5WF3
| Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 9k (SRI-30023) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-(2-phenoxyethyl)-1,6-dihydropyrimidine-4 -carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-07-11 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.251 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
|
|
5WFW
| Crystal structure of the influenza virus PA endonuclease (E119D mutant) in complex with inhibitor 10j (SRI-30026) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-ox o-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.292 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
|
|
3SQ7
| |
5WAP
| Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 10i (SRI-30025) | 分子名称: | 2-[(2S)-1-{[(2-chlorophenyl)sulfanyl]acetyl}pyrrolidin-2-yl]-N-(2,3-dihydro-1H-inden-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2017-06-26 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Sci Rep, 7, 2017
|
|
2F9T
| Structure of the type III CoaA from Pseudomonas aeruginosa | 分子名称: | Pantothenate Kinase | 著者 | Leonardi, R, Yun, M.K, Chohnan, S, White, S.W, Rock, C.O, Jackowski, S. | 登録日 | 2005-12-06 | 公開日 | 2006-08-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties. Structure, 14, 2006
|
|
2F9W
| Structure of the type III CoaA from Pseudomonas aeruginosa | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, PANTOTHENOIC ACID, ... | 著者 | Leonardi, R, Yun, M.K, Chohnan, S, White, S.W, Rock, C.O, Jackowski, S. | 登録日 | 2005-12-06 | 公開日 | 2006-08-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties. Structure, 14, 2006
|
|