5VPT
2009 H1N1 PA Endonuclease in complex with RO-7
Summary for 5VPT
| Entry DOI | 10.2210/pdb5vpt/pdb |
| Related | 5VP8 |
| Descriptor | Polymerase acidic protein, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | nuclease influenza inhibitor resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Influenza A virus More |
| Total number of polymer chains | 1 |
| Total formula weight | 23841.78 |
| Authors | Kumar, G.,White, S.W. (deposition date: 2017-05-05, release date: 2018-04-11, Last modification date: 2023-10-04) |
| Primary citation | Jones, J.C.,Kumar, G.,Barman, S.,Najera, I.,White, S.W.,Webby, R.J.,Govorkova, E.A. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. MBio, 9:-, 2018 Cited by PubMed: 29691337DOI: 10.1128/mBio.00430-18 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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