3BM9
 
 | | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | | 分子名称: | 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol, Heat shock protein HSP 90-alpha | | 著者 | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | | 登録日 | 2007-12-12 | | 公開日 | 2008-07-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
J.Med.Chem., 51, 2008
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3BMY
 | | Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 | | 分子名称: | 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol, Heat shock protein HSP 90-alpha | | 著者 | Gopalsamy, A, Shi, M, Vogan, E.M, Golas, J, Jacob, J, Johnson, J, Lee, F, Nilakantan, R, Peterson, R, Svenson, K, Tam, M.S, Wen, Y, Chopra, R, Ellingboe, J, Arndt, K, Boschelli, F. | | 登録日 | 2007-12-13 | | 公開日 | 2008-07-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
J.Med.Chem., 51, 2008
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6UZT
 | | Crystal Structure of RPTP alpha | | 分子名称: | Receptor-type tyrosine-protein phosphatase alpha | | 著者 | Santelli, E, Wen, Y, Yang, S, Svensson, M.N.D, Stanford, S.M, Bottini, N. | | 登録日 | 2019-11-15 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | RPTP alpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
J.Biol.Chem., 295, 2020
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6NSK
 | | CryoEM structure of Helicobacter pylori urea channel in open state. | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | | 著者 | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | | 登録日 | 2019-01-24 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
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6NSJ
 | | CryoEM structure of Helicobacter pylori urea channel in closed state | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, Acid-activated urea channel | | 著者 | Cui, Y.X, Zhou, K, Strugatsky, D, Wen, Y, Sachs, G, Munson, K, Zhou, Z.H. | | 登録日 | 2019-01-24 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | pH-dependent gating mechanism of theHelicobacter pyloriurea channel revealed by cryo-EM.
Sci Adv, 5, 2019
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8IMW
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6KCZ
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2KDY
 | | NMR structure of LP2086-B01 | | 分子名称: | Factor H binding protein variant B01_001 | | 著者 | Mascioni, A, Bentley, B.E, Camarda, R, Dilts, D.A, Fink, P, Gusarova, V, Hoiseth, S, Jacob, J, Lin, S.L, Malakian, K, McNeil, L.K, Mininni, T, Moy, F, Murphy, E, Novikova, E, Sigethy, S, Wen, Y, Zlotnick, G.W, Tsao, D.H.H. | | 登録日 | 2009-01-20 | | 公開日 | 2009-02-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086.
J.Biol.Chem., 284, 2009
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8GMY
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8GMZ
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2MUX
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7VPG
 | | Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 | | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | | 登録日 | 2021-10-17 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
Front Mol Biosci, 8, 2021
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7VPH
 | | Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 | | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | | 登録日 | 2021-10-17 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
Front Mol Biosci, 8, 2021
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3QBE
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