6UF7
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![BU of 6uf7 by Molmil](/molmil-images/mine/6uf7) | S2 symmetric peptide design number 5, Uncle Fester | Descriptor: | S2-5, Uncle Fester | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-23 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UF8
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![BU of 6uf8 by Molmil](/molmil-images/mine/6uf8) | S2 symmetric peptide design number 6, London Bridge | Descriptor: | S2-6, London Bridge | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-23 | Release date: | 2020-12-02 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UDR
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![BU of 6udr by Molmil](/molmil-images/mine/6udr) | S2 symmetric peptide design number 3 crystal form 1, Lurch | Descriptor: | S2-3, Lurch crystal form 1 | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-19 | Release date: | 2020-09-23 | Last modified: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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8T0B
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8T1N
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![BU of 8t1n by Molmil](/molmil-images/mine/8t1n) | Micro-ED Structure of a Novel Domain of Unknown Function Solved with AlphaFold | Descriptor: | DUF1842 domain-containing protein | Authors: | Miller, J.E, Cascio, D, Sawaya, M.R, Cannon, K.A, Rodriguez, J.A, Yeates, T.O. | Deposit date: | 2023-06-02 | Release date: | 2024-01-17 | Last modified: | 2024-04-10 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol, 80, 2024
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5ACL
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![BU of 5acl by Molmil](/molmil-images/mine/5acl) | Mcg immunoglobulin variable domain with sulfasalazine | Descriptor: | 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, MCG, SULFATE ION | Authors: | Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2015-08-17 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife, 4, 2015
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5IM4
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![BU of 5im4 by Molmil](/molmil-images/mine/5im4) | Crystal structure of designed two-component self-assembling icosahedral cage I52-32 | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase, Phosphotransferase system, mannose/fructose-specific component IIA | Authors: | Liu, Y.A, Cascio, D, Sawaya, M.R, Bale, J.B, Collazo, M.J, Thomas, C, Sheffler, W, King, N.P, Baker, D, Yeates, T.O. | Deposit date: | 2016-03-05 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Accurate design of megadalton-scale two-component icosahedral protein complexes. Science, 353, 2016
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8UMP
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![BU of 8ump by Molmil](/molmil-images/mine/8ump) | T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-18 | Release date: | 2023-11-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UF0
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![BU of 8uf0 by Molmil](/molmil-images/mine/8uf0) | T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-03 | Release date: | 2023-11-15 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.02 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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6N3A
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![BU of 6n3a by Molmil](/molmil-images/mine/6n3a) | SegA-long, conformation of TDP-43 low complexity domain segment A long | Descriptor: | TAR DNA-binding protein 43, segA long small | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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5ACM
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![BU of 5acm by Molmil](/molmil-images/mine/5acm) | Mcg immunoglobulin variable domain with methylene blue | Descriptor: | 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ... | Authors: | Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2015-08-17 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife, 4, 2015
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8UI2
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![BU of 8ui2 by Molmil](/molmil-images/mine/8ui2) | T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml28-redesigned-CutA-fold, T33-ml28-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-09 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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8UKM
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![BU of 8ukm by Molmil](/molmil-images/mine/8ukm) | T33-ml30 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | Descriptor: | T33-ml30-redesigned-4-OT-fold, T33-ml30-redesigned-tandem-BMC-T-fold | Authors: | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-10-14 | Release date: | 2024-03-06 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure, 32, 2024
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5WKB
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![BU of 5wkb by Molmil](/molmil-images/mine/5wkb) | MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-24 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WKD
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![BU of 5wkd by Molmil](/molmil-images/mine/5wkd) | Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-25 | Release date: | 2018-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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6WQK
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![BU of 6wqk by Molmil](/molmil-images/mine/6wqk) | hnRNPA2 Low complexity domain (LCD) determined by cryoEM | Descriptor: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-29 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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6UD9
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![BU of 6ud9 by Molmil](/molmil-images/mine/6ud9) | S2 symmetric peptide design number 2, Morticia | Descriptor: | S2-2, Morticia | Authors: | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | Deposit date: | 2019-09-19 | Release date: | 2020-09-23 | Last modified: | 2020-12-02 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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5WHP
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![BU of 5whp by Molmil](/molmil-images/mine/5whp) | Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | Segment of TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-17 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WIQ
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![BU of 5wiq by Molmil](/molmil-images/mine/5wiq) | Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-19 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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7ICF
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6WPQ
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![BU of 6wpq by Molmil](/molmil-images/mine/6wpq) | GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | Descriptor: | Heterogeneous nuclear ribonucleoprotein A2 | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-27 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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7ICP
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7ICL
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7ICV
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7ICU
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![BU of 7icu by Molmil](/molmil-images/mine/7icu) | |