5GWI
 
 | | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R | | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | | 著者 | Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L. | | 登録日 | 2016-09-12 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.737 Å) | | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
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5GWK
 | | Human topoisomerase IIalpha in complex with DNA and etoposide | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | | 著者 | Wang, Y.R, Wu, C.C, Chan, N.L. | | 登録日 | 2016-09-12 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
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5GWJ
 | | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S | | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | | 著者 | Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L. | | 登録日 | 2016-09-12 | | 公開日 | 2017-08-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.566 Å) | | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
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5WP9
 | | Structural Basis of Mitochondrial Receptor Binding and Constriction by Dynamin-Related Protein 1 | | 分子名称: | Dynamin-1-like protein, MAGNESIUM ION, Mitochondrial dynamics protein MID49, ... | | 著者 | Kalia, R, Wang, R.Y.R, Yusuf, A, Thomas, P.V, Agard, D.A, Shaw, J.M, Frost, A. | | 登録日 | 2017-08-03 | | 公開日 | 2018-06-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.22 Å) | | 主引用文献 | Structural basis of mitochondrial receptor binding and constriction by DRP1.
Nature, 558, 2018
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5FWK
 | | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ... | | 著者 | Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A. | | 登録日 | 2016-02-17 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
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5FWL
 | | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ... | | 著者 | Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A. | | 登録日 | 2016-02-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
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5FWM
 | | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ... | | 著者 | Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A. | | 登録日 | 2016-02-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
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5FWP
 | | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ... | | 著者 | Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A. | | 登録日 | 2016-02-18 | | 公開日 | 2016-10-26 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Atomic Structure of Hsp90:Cdc37:Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
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5ZEN
 | | Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate | | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | | 著者 | Chen, S.F, Wang, Y.R, Chan, N.L. | | 登録日 | 2018-02-27 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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5ZQF
 | | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221 | | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... | | 著者 | Chen, S.F, Wang, Y.R, Chan, N.L. | | 登録日 | 2018-04-18 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.873 Å) | | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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5ZRF
 | | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ... | | 著者 | Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L. | | 登録日 | 2018-04-24 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
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2ZED
 | | Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEH
 | | Crystal structure of the human glutaminyl cyclase mutant E201Q at 1.8 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEM
 | | Crystal structure of the human glutaminyl cyclase mutant D248Q at 2.18 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEP
 | | Crystal structure of the human glutaminyl cyclase mutant H319L at 2.1 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEE
 | | Crystal structure of the human glutaminyl cyclase mutant S160G at 1.99 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEL
 | | Crystal structure of the human glutaminyl cyclase mutant D248A at 1.97 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEF
 | | Crystal structure of the human glutaminyl cyclase mutant E201D at 1.67 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEG
 | | Crystal structure of the human glutaminyl cyclase mutant E201L at 2.08 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, IMIDAZOLE, SULFATE ION, ... | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEO
 | | Crystal structure of the human glutaminyl cyclase mutant D305E at 1.66 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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2ZEN
 | | Crystal structure of the human glutaminyl cyclase mutant D305A at 1.78 angstrom resolution | | 分子名称: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | | 著者 | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | | 登録日 | 2007-12-13 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Biochem.J., 411, 2008
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