1DCH
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![BU of 1dch by Molmil](/molmil-images/mine/1dch) | CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR | Descriptor: | DCOH (DIMERIZATION COFACTOR OF HNF-1), SULFATE ION | Authors: | Endrizzi, J.A, Cronk, J.D, Wang, W, Crabtree, G.R, Alber, T. | Deposit date: | 1995-01-24 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. Science, 268, 1995
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5VFQ
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![BU of 5vfq by Molmil](/molmil-images/mine/5vfq) | Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome non-ATPase regulatory subunit 12, ... | Authors: | Zhu, Y, Wang, W.L, Yu, D, Ouyang, Q, Lu, Y, Mao, Y. | Deposit date: | 2017-04-09 | Release date: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome. Nat Commun, 9, 2018
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5VZY
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![BU of 5vzy by Molmil](/molmil-images/mine/5vzy) | Crystal structure of crenezumab Fab in complex with Abeta | Descriptor: | Amyloid beta A4 protein, Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain | Authors: | Ultsch, M, Wang, W. | Deposit date: | 2017-05-29 | Release date: | 2017-08-09 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin. Sci Rep, 6, 2016
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4HO2
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![BU of 4ho2 by Molmil](/molmil-images/mine/4ho2) | |
8JKB
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![BU of 8jkb by Molmil](/molmil-images/mine/8jkb) | Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits | Descriptor: | BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Authors: | Zheng, S, Jiang, W, Wang, W, Kong, Y. | Deposit date: | 2023-06-01 | Release date: | 2023-07-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase. Sci Adv, 9, 2023
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4QYP
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![BU of 4qyp by Molmil](/molmil-images/mine/4qyp) | The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII) bound to Retinal | Descriptor: | ACETATE ION, RETINAL, Retinol-binding protein 2 | Authors: | Nossoni, Z, Assar, Z, Yapici, I, Nosrati, M, Wang, W, Berbasova, T, Vasileiou, C, Borhan, B, Geiger, H. | Deposit date: | 2014-07-25 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Acta Crystallogr.,Sect.D, 70, 2014
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3MX5
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![BU of 3mx5 by Molmil](/molmil-images/mine/3mx5) | Lassa fever virus nucleoprotein complexed with UTP | Descriptor: | Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2010-05-06 | Release date: | 2010-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature, 468, 2010
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4QYN
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![BU of 4qyn by Molmil](/molmil-images/mine/4qyn) | The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII) bound to Retinol | Descriptor: | ACETATE ION, RETINOL, Retinol-binding protein 2 | Authors: | Nossoni, Z, Assar, Z, Yapici, I, Nosrati, M, Wang, W, Berbasova, T, Vasileiou, C, Borhan, B, Geiger, H. | Deposit date: | 2014-07-24 | Release date: | 2014-12-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Acta Crystallogr.,Sect.D, 70, 2014
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3MWT
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![BU of 3mwt by Molmil](/molmil-images/mine/3mwt) | Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ | Descriptor: | MANGANESE (II) ION, Nucleoprotein, ZINC ION | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2010-05-06 | Release date: | 2010-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.982 Å) | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature, 468, 2010
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3MXN
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![BU of 3mxn by Molmil](/molmil-images/mine/3mxn) | Crystal structure of the RMI core complex | Descriptor: | BENZAMIDINE, RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | Authors: | Hoadley, K.A, Xu, D, Xue, Y, Satyshur, K.A, Wang, W, Keck, J.L. | Deposit date: | 2010-05-07 | Release date: | 2010-09-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. Structure, 18, 2010
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4TNX
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![BU of 4tnx by Molmil](/molmil-images/mine/4tnx) | Structure basis of cellular dNTP regulation, SAMHD1-GTP-dGTP complex | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. | Deposit date: | 2014-06-05 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
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3MWP
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![BU of 3mwp by Molmil](/molmil-images/mine/3mwp) | Nucleoprotein structure of lassa fever virus | Descriptor: | Nucleoprotein, ZINC ION | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2010-05-06 | Release date: | 2010-12-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature, 468, 2010
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4O10
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![BU of 4o10 by Molmil](/molmil-images/mine/4o10) | Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase | Descriptor: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}indolizine-7-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Wang, W. | Deposit date: | 2013-12-14 | Release date: | 2014-06-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
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4O28
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![BU of 4o28 by Molmil](/molmil-images/mine/4o28) | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors | Descriptor: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Coons, M, Brillantes, B, Wang, W. | Deposit date: | 2013-12-17 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
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4O1D
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![BU of 4o1d by Molmil](/molmil-images/mine/4o1d) | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors | Descriptor: | (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Coons, M, Brillantes, B, Wang, W. | Deposit date: | 2013-12-15 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.705 Å) | Cite: | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
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3NOJ
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![BU of 3noj by Molmil](/molmil-images/mine/3noj) | The structure of HMG/CHA aldolase from the protocatechuate degradation pathway of Pseudomonas putida | Descriptor: | 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase, MAGNESIUM ION, PYRUVIC ACID, ... | Authors: | Kimber, M.S, Wang, W, Mazurkewich, S, Seah, S.Y.K. | Deposit date: | 2010-06-25 | Release date: | 2010-09-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural and Kinetic Characterization of 4-Hydroxy-4-methyl-2-oxoglutarate/4-Carboxy-4-hydroxy-2-oxoadipate Aldolase, a Protocatechuate Degradation Enzyme Evolutionarily Convergent with the HpaI and DmpG Pyruvate Aldolases. J.Biol.Chem., 285, 2010
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3MX2
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![BU of 3mx2 by Molmil](/molmil-images/mine/3mx2) | Lassa fever virus Nucleoprotein complexed with dTTP | Descriptor: | Nucleoprotein, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2010-05-06 | Release date: | 2010-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.983 Å) | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature, 468, 2010
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7CLU
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![BU of 7clu by Molmil](/molmil-images/mine/7clu) | PigF with SAH | Descriptor: | ACETATE ION, GLYCEROL, Methyltransferase domain-containing protein | Authors: | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | Deposit date: | 2020-07-22 | Release date: | 2021-07-28 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism. Iucrj, 9, 2022
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4L4L
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![BU of 4l4l by Molmil](/molmil-images/mine/4l4l) | Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase | Descriptor: | 1,2-ETHANEDIOL, 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Ho, Y, Zak, M, Liu, Y, Yuen, P, Zheng, X, Dragovich, S.P, Wang, W. | Deposit date: | 2013-06-08 | Release date: | 2014-06-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.122 Å) | Cite: | Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
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7F77
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![BU of 7f77 by Molmil](/molmil-images/mine/7f77) | Crystal structure of glutamate dehydrogenase 3 from Candida albicans | Descriptor: | Glutamate dehydrogenase | Authors: | Li, N, Wang, W, Zeng, X, Liu, M, Li, M, Li, C, Wang, M. | Deposit date: | 2021-06-28 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.086 Å) | Cite: | Crystal structure of glutamate dehydrogenase 3 from Candida albicans. Biochem.Biophys.Res.Commun., 570, 2021
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5YIM
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![BU of 5yim by Molmil](/molmil-images/mine/5yim) | Structure of a Legionella effector | Descriptor: | SdeA | Authors: | Feng, Y, Dong, Y, Wang, W. | Deposit date: | 2017-10-05 | Release date: | 2018-05-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.394 Å) | Cite: | Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature, 557, 2018
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4O19
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![BU of 4o19 by Molmil](/molmil-images/mine/4o19) | The crystal structure of a mutant NAMPT (G217V) | Descriptor: | 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Oh, A, Coons, M, Brillantes, B, Wang, W. | Deposit date: | 2013-12-15 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
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4O13
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![BU of 4o13 by Molmil](/molmil-images/mine/4o13) | The crystal structure of NAMPT in complex with GNE-618 | Descriptor: | 1,2-ETHANEDIOL, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Coons, M, Brillantes, B, Wang, W. | Deposit date: | 2013-12-15 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors. Plos One, 9, 2014
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4DST
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![BU of 4dst by Molmil](/molmil-images/mine/4dst) | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | Descriptor: | 1,2-ETHANEDIOL, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, ACETATE ION, ... | Authors: | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | Deposit date: | 2012-02-19 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4L4M
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![BU of 4l4m by Molmil](/molmil-images/mine/4l4m) | Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase | Descriptor: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-7-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Oh, A, Ho, Y, Zak, M, Liu, Y, Yuen, P, Zheng, X, Dragovich, S.P, Wang, W. | Deposit date: | 2013-06-08 | Release date: | 2014-06-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.445 Å) | Cite: | Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
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