5JR3
 
 | | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone | | Descriptor: | 7-hydroxy-4-methyl-2H-chromen-2-one, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Wang, F, Johnson, B.R, Huber, T.D, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2016-05-05 | | Release date: | 2016-06-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published)
To Be Published
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5EJL
 | | MrkH, A novel c-di-GMP dependence transcription regulatory factor. | | Descriptor: | 1,2-ETHANEDIOL, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Klebsiella pneumoniae genome assembly NOVST, ... | | Authors: | Wang, F, Zhu, D, Gu, L. | | Deposit date: | 2015-11-02 | | Release date: | 2016-10-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The PilZ domain of MrkH represents a novel DNA binding motif
Protein Cell, 7, 2016
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6EF8
 | | Cryo-EM of the OmcS nanowires from Geobacter sulfurreducens | | Descriptor: | C-type cytochrome OmcS, HEME C | | Authors: | Wang, F, Gu, Y, Egelman, E.H, Malvankar, N.S. | | Deposit date: | 2018-08-16 | | Release date: | 2019-04-10 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers.
Cell, 177, 2019
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5GWZ
 | | The structure of Porcine epidemic diarrhea virus main protease in complex with an inhibitor | | Descriptor: | N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, PEDV main protease | | Authors: | Wang, F, Chen, C, Yang, K, Liu, X, Liu, H, Xu, Y, Chen, X, Liu, X, Cai, Y, Yang, H. | | Deposit date: | 2016-09-14 | | Release date: | 2017-03-29 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.444 Å) | | Cite: | Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60, 2017
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8EWI
 | | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form | | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | | Authors: | Wang, F, He, Q, Lin, G, Li, H. | | Deposit date: | 2022-10-23 | | Release date: | 2023-04-19 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
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6UQC
 | | Mouse IgG2a Bispecific Fc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, F, Tsai, J.C, Davis, J.H, West, S.M, Strop, P. | | Deposit date: | 2019-10-18 | | Release date: | 2020-01-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models.
Mabs, 12, 2019
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6V7B
 | | Cryo-EM reconstruction of Pyrobaculum filamentous virus 2 (PFV2) | | Descriptor: | A-DNA, Structural protein VP1, Structural protein VP2 | | Authors: | Wang, F, Baquero, D.P, Su, Z, Prangishvili, D, Krupovic, M, Egelman, E.H. | | Deposit date: | 2019-12-08 | | Release date: | 2020-04-01 | | Last modified: | 2020-05-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of a filamentous virus uncovers familial ties within the archaeal virosphere.
Virus Evol, 6, 2020
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8FJ5
 | | Structure of the Haloferax volcanii archaeal type IV pilus | | Descriptor: | Pilin_N domain-containing protein | | Authors: | Wang, F, Kreutzberger, M.A, Baquero, D.P, Krupovic, M, Egelman, E.H. | | Deposit date: | 2022-12-19 | | Release date: | 2023-06-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The evolution of archaeal flagellar filaments.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8FK7
 | | Structure of the Pyrobaculum calidifontis flagellar-like archaeal type IV pilus | | Descriptor: | Flagellin | | Authors: | Wang, F, Kreutzberger, M.A, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2022-12-20 | | Release date: | 2023-06-28 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | The evolution of archaeal flagellar filaments.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6W8U
 | | Cryo-EM of the Pyrobaculum arsenaticum pilus | | Descriptor: | pilin | | Authors: | Wang, F, Baquero, D.P, Su, Z, Beltran, L.C, Prangishvili, D, Krupovic, M, Egelman, E.H. | | Deposit date: | 2020-03-21 | | Release date: | 2020-07-08 | | Last modified: | 2021-10-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The structures of two archaeal type IV pili illuminate evolutionary relationships.
Nat Commun, 11, 2020
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6NAV
 | | Cryo-EM reconstruction of Sulfolobus islandicus LAL14/1 Pilus | | Descriptor: | M9UD72 | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Prangishvili, D, Krupovic, M, Egelman, E.H. | | Deposit date: | 2018-12-06 | | Release date: | 2019-05-08 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | An extensively glycosylated archaeal pilus survives extreme conditions.
Nat Microbiol, 4, 2019
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6UHY
 | | WDR5 in complex with Myc site fragment inhibitor | | Descriptor: | 1-cyclohexyl-1H-benzimidazole-5-carboxylic acid, WDR5 | | Authors: | Wang, F, Fesik, S.W. | | Deposit date: | 2019-09-29 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
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6UHZ
 | | WDR5 in complex with Myc site fragment inhibitor | | Descriptor: | 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 | | Authors: | Wang, F, Fesik, S.w. | | Deposit date: | 2019-09-29 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.258 Å) | | Cite: | Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 63, 2020
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6ZZR
 | | The Crystal Structure of human LDHA from Biortus. | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, L-lactate dehydrogenase A chain | | Authors: | Wang, F, Lin, D, Cheng, W, Bao, X, Zhu, B, Shang, H. | | Deposit date: | 2020-08-05 | | Release date: | 2020-08-19 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | The Crystal Structure of human LDHA from Biortus
To Be Published
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6W8X
 | | Cryo-EM of the S. solfataricus pilus | | Descriptor: | pilin | | Authors: | Wang, F, Baquero, D.P, Su, Z, Beltran, L.C, Prangishvili, D, Krupovic, M, Egelman, E.H. | | Deposit date: | 2020-03-21 | | Release date: | 2020-07-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | The structures of two archaeal type IV pili illuminate evolutionary relationships.
Nat Commun, 11, 2020
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6WL7
 | | Cryo-EM of Form 2 like peptide filament, 29-20-2 | | Descriptor: | peptide 29-20-2 | | Authors: | Wang, F, Gnewou, O.M, Modlin, C, Egelman, E.H, Conticello, V.P. | | Deposit date: | 2020-04-18 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural analysis of cross alpha-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials.
Nat Commun, 12, 2021
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7RO4
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 3 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROI
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 12 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7RO2
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 1 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROH
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 11 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROG
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 10 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROE
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 9 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROC
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 7 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7RO5
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 4 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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7ROB
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 6 | | Descriptor: | major capsid protein | | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | Deposit date: | 2021-07-30 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
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