7E4P
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![BU of 7e4p by Molmil](/molmil-images/mine/7e4p) | Crystal structure of tubulin in complex with Ansamitocin P3 | Descriptor: | (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Li, W. | Deposit date: | 2021-02-14 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids To Be Published
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5UHR
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![BU of 5uhr by Molmil](/molmil-images/mine/5uhr) | |
7E4Y
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![BU of 7e4y by Molmil](/molmil-images/mine/7e4y) | Crystal structure of tubulin in complex with L-DM4-SMe | Descriptor: | (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Li, W. | Deposit date: | 2021-02-16 | Release date: | 2022-02-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.708 Å) | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids To Be Published
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8ITR
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![BU of 8itr by Molmil](/molmil-images/mine/8itr) | |
8ITT
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![BU of 8itt by Molmil](/molmil-images/mine/8itt) | |
5H00
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![BU of 5h00 by Molmil](/molmil-images/mine/5h00) | |
5UJT
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![BU of 5ujt by Molmil](/molmil-images/mine/5ujt) | Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-beta-1, ... | Authors: | Wang, Y, Dai, S. | Deposit date: | 2017-01-18 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4DFG
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![BU of 4dfg by Molmil](/molmil-images/mine/4dfg) | Crystal Structure of Wild-type HIV-1 Protease with Cyclopentyltetrahydro- furanyl Urethanes as P2-ligand, GRL-0249A | Descriptor: | CHLORIDE ION, Protease, SODIUM ION, ... | Authors: | Wang, Y.-F, Agniswamy, J, Weber, I.T. | Deposit date: | 2012-01-23 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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5GZX
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![BU of 5gzx by Molmil](/molmil-images/mine/5gzx) | |
5V39
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![BU of 5v39 by Molmil](/molmil-images/mine/5v39) | |
1DE1
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![BU of 1de1 by Molmil](/molmil-images/mine/1de1) | |
8K1O
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![BU of 8k1o by Molmil](/molmil-images/mine/8k1o) | mycobacterial efflux pump, AMPPNP bound state | Descriptor: | CARDIOLIPIN, MAGNESIUM ION, Multidrug efflux system ATP-binding protein Rv1218c, ... | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | Deposit date: | 2023-07-11 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | mycobacterial efflux pump, AMPPNP bound state To Be Published
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8K1N
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![BU of 8k1n by Molmil](/molmil-images/mine/8k1n) | mycobacterial efflux pump, substrate-bound state | Descriptor: | CARDIOLIPIN, Multidrug efflux system ATP-binding protein Rv1218c, Multidrug efflux system permease protein Rv1217c, ... | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | Deposit date: | 2023-07-11 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | mycobacterial efflux pump, substrate-bound state To Be Published
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8K1P
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![BU of 8k1p by Molmil](/molmil-images/mine/8k1p) | mycobacterial efflux pump, ADP+vanadate bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | Deposit date: | 2023-07-11 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | mycobacterial efflux pump, ADP+vanadate bound state To Be Published
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5H6Y
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![BU of 5h6y by Molmil](/molmil-images/mine/5h6y) | |
5G4C
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![BU of 5g4c by Molmil](/molmil-images/mine/5g4c) | Human SIRT2 catalyse short chain fatty acyl lysine | Descriptor: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2, SIRT2, ... | Authors: | Wang, Y. | Deposit date: | 2016-05-09 | Release date: | 2017-05-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. J. Am. Chem. Soc., 138, 2016
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1CW5
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![BU of 1cw5 by Molmil](/molmil-images/mine/1cw5) | SOLUTION STRUCTURE OF CARNOBACTERIOCIN B2 | Descriptor: | TYPE IIA BACTERIOCIN CARNOBACTERIOCIN B2 | Authors: | Wang, Y, Henz, M.E, Gallagher, N.L.F, Chai, S, Yan, L.Z, Gibbs, A.C, Stiles, M.E, Wishart, D.S, Vederas, J.C. | Deposit date: | 1999-08-25 | Release date: | 1999-09-07 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. Biochemistry, 38, 1999
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3HK2
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![BU of 3hk2 by Molmil](/molmil-images/mine/3hk2) | Crystal structure of T. thermophilus Argonaute N478 mutant protein complexed with DNA guide strand and 19-nt RNA target strand | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | Deposit date: | 2009-05-22 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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1CW6
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![BU of 1cw6 by Molmil](/molmil-images/mine/1cw6) | REFINED SOLUTION STRUCTURE OF LEUCOCIN A | Descriptor: | TYPE IIA BACTERIOCIN LEUCOCIN A | Authors: | Wang, Y, Henz, M.E, Gallagher, N.L.F, Chai, S, Yan, L.Z, Gibbs, A.C, Stiles, M.E, Wishart, D.S, Vederas, J.C. | Deposit date: | 1999-08-25 | Release date: | 1999-09-08 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. Biochemistry, 38, 1999
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1R6K
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![BU of 1r6k by Molmil](/molmil-images/mine/1r6k) | HPV11 E2 TAD crystal structure | Descriptor: | HPV11 REGULATORY PROTEIN E2 | Authors: | Wang, Y, Coulombe, R. | Deposit date: | 2003-10-15 | Release date: | 2004-02-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor J.Biol.Chem., 279, 2004
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3TDL
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![BU of 3tdl by Molmil](/molmil-images/mine/3tdl) | Structure of human serum albumin in complex with DAUDA | Descriptor: | 11-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)undecanoic acid, MYRISTIC ACID, Serum albumin | Authors: | Wang, Y, Luo, Z, Shi, X, Wang, H, Nie, L. | Deposit date: | 2011-08-11 | Release date: | 2012-06-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin Protein Sci., 20, 2011
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1DE2
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![BU of 1de2 by Molmil](/molmil-images/mine/1de2) | |
5GZY
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![BU of 5gzy by Molmil](/molmil-images/mine/5gzy) | |
1R6N
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![BU of 1r6n by Molmil](/molmil-images/mine/1r6n) | HPV11 E2 TAD complex crystal structure | Descriptor: | 2-METHYL-PROPIONIC ACID, DIMETHYL SULFOXIDE, HPV11 REGULATORY PROTEIN E2, ... | Authors: | Wang, Y, Coulombe, R. | Deposit date: | 2003-10-15 | Release date: | 2004-02-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the E2 Transactivation Domain of Human
Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor J.Biol.Chem., 279, 2004
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3HVR
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![BU of 3hvr by Molmil](/molmil-images/mine/3hvr) | Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand with two Mg2+ at the cleavage site | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*TP*GP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | Deposit date: | 2009-06-16 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.211 Å) | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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