4N9B
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![BU of 4n9b by Molmil](/molmil-images/mine/4n9b) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhai, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.859 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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8TNN
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![BU of 8tnn by Molmil](/molmil-images/mine/8tnn) | Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with gp42 antibody A10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, A10 heavy chain, A10 light chain, ... | Authors: | Bu, W, Kumar, A, Board, N, Kim, J, Dowdell, K, Zhang, S, Lei, Y, Hostal, A, Krogmann, T, Wang, Y, Pittaluga, S, Marcotrigiano, J, Cohen, J.I. | Deposit date: | 2023-08-02 | Release date: | 2024-03-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells. Immunity, 57, 2024
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4N9D
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![BU of 4n9d by Molmil](/molmil-images/mine/4n9d) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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8TNT
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![BU of 8tnt by Molmil](/molmil-images/mine/8tnt) | Crystal structure of Epstein-Barr virus gH/gL/gp42 in complex with antibodies F-2-1 and 769C2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 769C2 heavy chain, 769C2 light chain, ... | Authors: | Bu, W, Kumar, A, Board, N, Kim, J, Dowdell, K, Zhang, S, Lei, Y, Hostal, A, Krogmann, T, Wang, Y, Pittaluga, S, Marcotrigiano, J, Cohen, J.I. | Deposit date: | 2023-08-02 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells. Immunity, 57, 2024
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8TOO
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![BU of 8too by Molmil](/molmil-images/mine/8too) | Crystal structure of Epstein-Barr virus gp42 in complex with antibody 4C12 | Descriptor: | 4C12 heavy chain, 4C12 light chain, Glycoprotein 42 | Authors: | Bu, W, Kumar, A, Board, N, Kim, J, Dowdell, K, Zhang, S, Lei, Y, Hostal, A, Krogmann, T, Wang, Y, Pittaluga, S, Marcotrigiano, J, Cohen, J.I. | Deposit date: | 2023-08-03 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells. Immunity, 57, 2024
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6O5N
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![BU of 6o5n by Molmil](/molmil-images/mine/6o5n) | Tubulin-RB3_SLD-TTL in complex with compound 10ab | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Kumar, G, Wang, Y, Li, W, White, S.W. | Deposit date: | 2019-03-04 | Release date: | 2019-07-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J.Med.Chem., 62, 2019
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7CE2
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![BU of 7ce2 by Molmil](/molmil-images/mine/7ce2) | The Crystal structure of TeNT Hc complexed with neutralizing antibody | Descriptor: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | Authors: | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | Deposit date: | 2020-06-21 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies. Cell Rep, 35, 2021
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2WOQ
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![BU of 2woq by Molmil](/molmil-images/mine/2woq) | Porphobilinogen Synthase (HemB) in Complex with 5-acetamido-4- oxohexanoic acid (Alaremycin 2) | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALAREMYCIN 2, ... | Authors: | Heinemann, I.U, Schulz, C, Schubert, W.-D, Heinz, D.W, Wang, Y.-G, Kobayashi, Y, Awa, Y, Wachi, M, Jahn, D, Jahn, M. | Deposit date: | 2009-07-27 | Release date: | 2009-10-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob. Agents Chemother., 54, 2010
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1EHB
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![BU of 1ehb by Molmil](/molmil-images/mine/1ehb) | CRYSTAL STRUCTURE OF RECOMBINANT TRYPSIN-SOLUBILIZED FRAGMENT OF CYTOCHROME B5 | Descriptor: | PROTEIN (CYTOCHROME B5), PROTOPORPHYRIN IX CONTAINING FE | Authors: | Wu, J, Gan, J.-H, Xia, Z.-X, Wang, Y.-H, Wang, W.-H, Xue, L.-L, Xie, Y, Huang, Z.-X. | Deposit date: | 2000-02-20 | Release date: | 2000-08-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of recombinant trypsin-solubilized fragment of cytochrome b(5) and the structural comparison with Val61His mutant. Proteins, 40, 2000
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1M2I
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![BU of 1m2i by Molmil](/molmil-images/mine/1m2i) | Crystal structure of E44A/E56A mutant of cytochrome b5 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | Authors: | Wu, J, Wang, Y.-H, Gan, J.-H, Wang, W.-H, Sun, B.-Y, Huang, Z.-X, Xia, Z.-X. | Deposit date: | 2002-06-24 | Release date: | 2003-03-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of Cytochrome b5 Mutated at the Charged Surface-Residues and Their Interactions with Cytochrome c Chin.J.Chem., 20, 2002
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4N9C
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![BU of 4n9c by Molmil](/molmil-images/mine/4n9c) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 5-nitro-1H-benzimidazole, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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1ES1
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![BU of 1es1 by Molmil](/molmil-images/mine/1es1) | CRYSTAL STRUCTURE OF VAL61HIS MUTANT OF TRYPSIN-SOLUBILIZED FRAGMENT OF CYTOCHROME B5 | Descriptor: | CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Wu, J, Gan, J.-H, Xia, Z.-X, Wang, Y.-H, Wang, W.-H, Xue, L.-L, Xie, Y, Huang, Z.-X. | Deposit date: | 2000-04-07 | Release date: | 2000-08-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of recombinant trypsin-solubilized fragment of cytochrome b(5) and the structural comparison with Val61His mutant. Proteins, 40, 2000
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1LQX
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![BU of 1lqx by Molmil](/molmil-images/mine/1lqx) | Crystal structure of V45E mutant of cytochrome b5 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | Authors: | Gan, J.-H, Wu, J, Wang, Z.-Q, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X. | Deposit date: | 2002-05-14 | Release date: | 2002-09-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of V45E and V45Y mutants and structure comparison of a variety of cytochrome b5 mutants. Acta Crystallogr.,Sect.D, 58, 2002
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1LR6
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![BU of 1lr6 by Molmil](/molmil-images/mine/1lr6) | Crystal structure of V45Y mutant of cytochrome b5 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | Authors: | Gan, J.-H, Wu, J, Wang, Z.-Q, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X. | Deposit date: | 2002-05-15 | Release date: | 2002-09-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of V45E and V45Y mutants and structure comparison of a variety of cytochrome b5 mutants. Acta Crystallogr.,Sect.D, 58, 2002
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6LKQ
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![BU of 6lkq by Molmil](/molmil-images/mine/6lkq) | The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Zhang, L, Wang, Y.H, Lancaster, L, Zhou, J, Noller, H.F. | Deposit date: | 2019-12-20 | Release date: | 2020-05-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structural basis for inhibition of ribosomal translocation by viomycin. Proc.Natl.Acad.Sci.USA, 117, 2020
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1M20
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![BU of 1m20 by Molmil](/molmil-images/mine/1m20) | Crystal Structure of F35Y Mutant of Trypsin-solubilized Fragment of Cytochrome b5 | Descriptor: | Cytochrome b5, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Yao, P, Wu, J, Wang, Y.-H, Sun, B.-Y, Xia, Z.-X, Huang, Z.-X. | Deposit date: | 2002-06-20 | Release date: | 2002-09-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray crystallography, CD and kinetic studies revealed the essence of the abnormal behaviors of the cytochrome b5 Phe35-->Tyr mutant. Eur.J.Biochem., 269, 2002
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6J76
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![BU of 6j76 by Molmil](/molmil-images/mine/6j76) | Structure of 3,6-anhydro-L-galactose Dehydrogenase in Complex with NAP | Descriptor: | Aldehyde dehydrogenase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z. | Deposit date: | 2019-01-17 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.368 Å) | Cite: | 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248. J.Mol.Biol., 432, 2020
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6J75
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![BU of 6j75 by Molmil](/molmil-images/mine/6j75) | Structure of 3,6-anhydro-L-galactose Dehydrogenase | Descriptor: | Aldehyde dehydrogenase A | Authors: | Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z. | Deposit date: | 2019-01-17 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.695 Å) | Cite: | 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248. J.Mol.Biol., 432, 2020
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8GXD
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![BU of 8gxd by Molmil](/molmil-images/mine/8gxd) | L-LEUCINE DEHYDROGENASE FROM EXIGUOBACTERIUM SIBIRICUM | Descriptor: | CALCIUM ION, GLYCEROL, Glu/Leu/Phe/Val dehydrogenase | Authors: | Mu, X, Nie, Y, Wu, T, Wang, Y, Zhang, N, Yin, D, Xu, Y. | Deposit date: | 2022-09-19 | Release date: | 2023-04-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Reshaping Substrate-Binding Pocket of Leucine Dehydrogenase for Bidirectionally Accessing Structurally Diverse Substrates Acs Catalysis, 13, 2023
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5VEX
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![BU of 5vex by Molmil](/molmil-images/mine/5vex) | Structure of the human GLP-1 receptor complex with NNC0640 | Descriptor: | 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, Glucagon-like peptide 1 receptor, Endolysin chimera | Authors: | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | Deposit date: | 2017-04-05 | Release date: | 2017-05-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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8GRX
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![BU of 8grx by Molmil](/molmil-images/mine/8grx) | APOE4 receptor in complex with APOE4 NTD | Descriptor: | Apolipoprotein E, Leukocyte immunoglobulin-like receptor subfamily A member 6 | Authors: | Zhou, J, Wang, Y, Huang, G, Shi, Y. | Deposit date: | 2022-09-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | LilrB3 is a putative cell surface receptor of APOE4. Cell Res., 33, 2023
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5VEW
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![BU of 5vew by Molmil](/molmil-images/mine/5vew) | Structure of the human GLP-1 receptor complex with PF-06372222 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, ... | Authors: | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | Deposit date: | 2017-04-05 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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8WQR
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![BU of 8wqr by Molmil](/molmil-images/mine/8wqr) | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation | Descriptor: | Activating molecule in BECN1-regulated autophagy protein 1, DNA damage-binding protein 1 | Authors: | Liu, M, Wang, Y, Su, M.Y, Stjepanovic, G. | Deposit date: | 2023-10-12 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation. Nat Commun, 14, 2023
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5D8O
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![BU of 5d8o by Molmil](/molmil-images/mine/5d8o) | 1.90A resolution structure of BfrB (wild-type, C2221 form) from Pseudomonas aeruginosa | Descriptor: | Ferroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M. | Deposit date: | 2015-08-17 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots. Biochemistry, 54, 2015
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2ZED
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![BU of 2zed by Molmil](/molmil-images/mine/2zed) | Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 angstrom resolution | Descriptor: | Glutaminyl-peptide cyclotransferase, SULFATE ION, ZINC ION | Authors: | Huang, K.F, Wang, Y.R, Chang, E.C, Chou, T.L, Wang, A.H. | Deposit date: | 2007-12-12 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. Biochem.J., 411, 2008
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