7V5J
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![BU of 7v5j by Molmil](/molmil-images/mine/7v5j) | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | 分子名称: | 0722 H, 0722 L, Spike glycoprotein | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | 登録日 | 2021-08-17 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) to be published
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6LY3
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![BU of 6ly3 by Molmil](/molmil-images/mine/6ly3) | PylRS C-terminus domain mutant bound with 3-Benzothienyl-L-alanine and AMPNP | 分子名称: | 3-(1-benzothiophen-3-yl)-L-alanine, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.89590144 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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7V6N
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![BU of 7v6n by Molmil](/molmil-images/mine/7v6n) | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | 分子名称: | 111 H, 111 L, Spike glycoprotein | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | 登録日 | 2021-08-20 | 公開日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 to be published
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7V6O
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![BU of 7v6o by Molmil](/molmil-images/mine/7v6o) | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | 分子名称: | 111 H, 111 L, Spike glycoprotein | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | 登録日 | 2021-08-20 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (4.56 Å) | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) to be published
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8OR7
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![BU of 8or7 by Molmil](/molmil-images/mine/8or7) | Structure of a far-red induced allophycocyanin from Chroococcidiopsis thermalis sp. PCC 7203 | 分子名称: | Allophycocyanin beta subunit apoprotein, PHYCOCYANOBILIN, POTASSIUM ION, ... | 著者 | Zhou, L.J, Hoeppner, A, Wang, Y.Q, Zhao, K.H. | 登録日 | 2023-04-13 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystallographic and biochemical analyses of a far-red allophycocyanin to address the mechanism of the super-red-shift. Photosynth.Res., 2024
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5YDG
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![BU of 5ydg by Molmil](/molmil-images/mine/5ydg) | Crystal structure of the Arabidopsis thaliana chloroplast RNA editing factors 2(MORF2) | 分子名称: | Multiple organellar RNA editing factor 2, chloroplastic | 著者 | Wang, X, Yang, J.Y, Wang, Y.L, Gao, Y.S. | 登録日 | 2017-09-13 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | 主引用文献 | Crystal structure of the chloroplast RNA editing factor MORF2 Biochem. Biophys. Res. Commun., 495, 2018
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7D3I
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![BU of 7d3i by Molmil](/molmil-images/mine/7d3i) | Crystal structure of SARS-CoV-2 main protease in complex with MI-23 | 分子名称: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[3-[3,5-bis(fluoranyl)phenyl]propanoyl]-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase | 著者 | Zeng, R, Li, Y.S, Qiao, J.X, Wang, Y.F, Yang, S.Y, Lei, J. | 登録日 | 2020-09-19 | 公開日 | 2020-10-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
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5GNF
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![BU of 5gnf by Molmil](/molmil-images/mine/5gnf) | |
5YEL
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![BU of 5yel by Molmil](/molmil-images/mine/5yel) | Crystal structure of CTCF ZFs6-11-gb7CSE | 分子名称: | DNA (26-MER), Transcriptional repressor CTCF, ZINC ION | 著者 | Yin, M, Wang, J, Wang, M, Li, X, Wang, Y. | 登録日 | 2017-09-18 | 公開日 | 2017-11-29 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Cell Res., 27, 2017
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1U9M
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![BU of 1u9m by Molmil](/molmil-images/mine/1u9m) | Crystal structure of F58W mutant of cytochrome b5 | 分子名称: | Cytochrome b5, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Shan, L, Lu, J.-X, Gan, J.-H, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X. | 登録日 | 2004-08-10 | 公開日 | 2005-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the F58W mutant of cytochrome b5: the mutation leads to multiple conformations and weakens stacking interactions. Acta Crystallogr.,Sect.D, 61, 2005
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6LY7
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![BU of 6ly7 by Molmil](/molmil-images/mine/6ly7) | PylRS C-terminus domain mutant bound with 1-Formyl-L-tryptophan and AMPNP | 分子名称: | MAGNESIUM ION, N1-FORMYL-TRYPTOPHAN, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09447265 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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3H5B
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![BU of 3h5b by Molmil](/molmil-images/mine/3h5b) | Crystal structure of wild type HIV-1 protease with novel P1'-ligand GRL-02031 | 分子名称: | (3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl [(1S,2R)-1-benzyl-2-hydroxy-3-([(4-methoxyphenyl)sulfonyl]{[(2R)-5-oxopyrrolidin-2-yl]methyl}amino)propyl]carbamate, CHLORIDE ION, GLYCEROL, ... | 著者 | Tie, Y, Wang, Y.F, Weber, I.T. | 登録日 | 2009-04-21 | 公開日 | 2009-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies. J.Med.Chem., 52, 2009
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1BVE
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![BU of 1bve by Molmil](/molmil-images/mine/1bve) | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES | 分子名称: | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE | 著者 | Yamazaki, T, Hinck, A.P, Wang, Y.-X, Nicholson, L.K, Torchia, D.A, Wingfield, P, Stahl, S.J, Kaufman, J.D, Chang, C, Domaille, P.J, Lam, P.Y.S. | 登録日 | 1996-01-16 | 公開日 | 1996-08-17 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy. Protein Sci., 5, 1996
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1BVG
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![BU of 1bvg by Molmil](/molmil-images/mine/1bvg) | HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | 分子名称: | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE | 著者 | Yamazaki, T, Hinck, A.P, Wang, Y.-X, Nicholson, L.K, Torchia, D.A, Wingfield, P, Stahl, S.J, Kaufman, J.D, Chang, C, Domaille, P.J, Lam, P.Y.S. | 登録日 | 1996-01-16 | 公開日 | 1996-08-17 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy. Protein Sci., 5, 1996
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5D8Q
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![BU of 5d8q by Molmil](/molmil-images/mine/5d8q) | 2.20A resolution structure of BfrB (L68A) from Pseudomonas aeruginosa | 分子名称: | ARSENIC, Ferroxidase, MAGNESIUM ION, ... | 著者 | Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M. | 登録日 | 2015-08-17 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots. Biochemistry, 54, 2015
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5D8O
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![BU of 5d8o by Molmil](/molmil-images/mine/5d8o) | 1.90A resolution structure of BfrB (wild-type, C2221 form) from Pseudomonas aeruginosa | 分子名称: | Ferroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M. | 登録日 | 2015-08-17 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots. Biochemistry, 54, 2015
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5UY8
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![BU of 5uy8 by Molmil](/molmil-images/mine/5uy8) | Crystal structure of AICARFT bound to an antifolate | 分子名称: | 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, ... | 著者 | Wang, J, Wang, Y, Fales, K.R, Atwell, S, Clawson, D. | 登録日 | 2017-02-23 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
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5UZ0
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![BU of 5uz0 by Molmil](/molmil-images/mine/5uz0) | Crystal structure of AICARFT bound to an antifolate | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, MAGNESIUM ION, ... | 著者 | Atwell, S, Wang, Y, Fales, K.R, Clawson, D, Wang, J. | 登録日 | 2017-02-24 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J. Med. Chem., 60, 2017
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5V9U
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![BU of 5v9u by Molmil](/molmil-images/mine/5v9u) | Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. | 登録日 | 2017-03-23 | 公開日 | 2018-02-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell, 172, 2018
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1OV2
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![BU of 1ov2 by Molmil](/molmil-images/mine/1ov2) | Ensemble of the solution structures of domain one of receptor associated protein | 分子名称: | Alpha-2-macroglobulin receptor-associated protein precursor | 著者 | Wu, Y, Migliorini, M, Yu, P, Strickland, D.K, Wang, Y.X. | 登録日 | 2003-03-25 | 公開日 | 2004-04-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. J.Biomol.Nmr, 26, 2003
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1PCG
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![BU of 1pcg by Molmil](/molmil-images/mine/1pcg) | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions | 分子名称: | ESTRADIOL, estrogen receptor, peptide inhibitor | 著者 | Leduc, A.M, Trent, J.O, Wittliff, J.L, Bramlett, K.S, Briggs, S.L, Chirgadze, N.Y, Wang, Y, Burris, T.P, Spatola, A.F. | 登録日 | 2003-05-16 | 公開日 | 2003-10-28 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions Proc.Natl.Acad.Sci.USA, 100, 2003
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6JFU
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![BU of 6jfu by Molmil](/molmil-images/mine/6jfu) | Crystal structure of Nme2Cas9 in complex with sgRNA and target DNA (AGGCCC PAM) | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, non-target strand, ... | 著者 | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | 登録日 | 2019-02-12 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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8SA2
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![BU of 8sa2 by Molmil](/molmil-images/mine/8sa2) | Adenosylcobalamin-bound riboswitch dimer, form 1 | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 1 | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | 登録日 | 2023-03-31 | 公開日 | 2023-07-26 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM. Nucleic Acids Res., 51, 2023
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8SA4
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![BU of 8sa4 by Molmil](/molmil-images/mine/8sa4) | Adenosylcobalamin-bound riboswitch dimer, form 3 | 分子名称: | Adenosylcobalamin, adenosylcobalamin riboswitch form 3 | 著者 | Ding, J, Deme, J.C, Stagno, J.R, Yu, P, Lea, S.M, Wang, Y.X. | 登録日 | 2023-03-31 | 公開日 | 2023-07-26 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM. Nucleic Acids Res., 51, 2023
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1PDQ
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![BU of 1pdq by Molmil](/molmil-images/mine/1pdq) | Polycomb chromodomain complexed with the histone H3 tail containing trimethyllysine 27. | 分子名称: | Histone H3.3, Polycomb protein | 著者 | Fischle, W, Wang, Y, Jacobs, S.A, Kim, Y, Allis, C.D, Khorasanizadeh, S. | 登録日 | 2003-05-20 | 公開日 | 2003-08-26 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains Genes Dev., 17, 2003
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