2HD1
| Crystal structure of PDE9 in complex with IBMX | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ... | Authors: | Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H. | Deposit date: | 2006-06-19 | Release date: | 2006-06-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding Proc.Natl.Acad.Sci.USA, 101, 2004
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7EW3
| Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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5XMI
| Cryo-EM Structure of the ATP-bound VPS4 mutant-E233Q hexamer (masked) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vacuolar protein sorting-associated protein 4 | Authors: | Sun, S, Li, L, Yang, F, Wang, X, Fan, F, Li, X, Wang, H, Sui, S. | Deposit date: | 2017-05-15 | Release date: | 2017-08-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of the ATP-bound Vps4(E233Q) hexamer and its complex with Vta1 at near-atomic resolution Nat Commun, 8, 2017
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7TN3
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3CWI
| Crystal structure of thiamine biosynthesis protein (ThiS) from Geobacter metallireducens. Northeast Structural Genomics Consortium Target GmR137 | Descriptor: | Thiamine-biosynthesis protein ThiS | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Mao, L, Janjua, H, Xiao, R, Maglaqui, M, Ciccosanti, C, Foote, E.L, Wang, H, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-04-21 | Release date: | 2008-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of thiamine biosynthesis protein (ThiS) from Geobacter metallireducens. To be Published
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5H1B
| Human RAD51 presynaptic complex | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, MAGNESIUM ION, ... | Authors: | Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W. | Deposit date: | 2016-10-08 | Release date: | 2016-12-21 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange Nat. Struct. Mol. Biol., 24, 2017
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5YYS
| Cryo-EM structure of L-fucokinase, GDP-fucose pyrophosphorylase (FKP)in Bacteroides fragilis | Descriptor: | L-fucokinase, L-fucose-1-P guanylyltransferase | Authors: | Wang, J, Hu, H, Liu, Y, Zhou, Q, Wu, P, Yan, N, Wang, H.W, Wu, J.W, Sun, L. | Deposit date: | 2017-12-11 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis. Protein Cell, 10, 2019
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5H1C
| Human RAD51 post-synaptic complexes | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ... | Authors: | Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W. | Deposit date: | 2016-10-08 | Release date: | 2016-12-21 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange Nat. Struct. Mol. Biol., 24, 2017
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2Z8N
| Structural basis for the catalytic mechanism of phosphothreonine lyase | Descriptor: | 27.5 kDa virulence protein, SULFATE ION | Authors: | Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J. | Deposit date: | 2007-09-07 | Release date: | 2007-12-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat.Struct.Mol.Biol., 15, 2008
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7DQA
| Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | Authors: | Wang, J, Lan, J, Wang, X.Q, Wang, H.W. | Deposit date: | 2020-12-22 | Release date: | 2021-12-29 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM Biophys Rep, 7, 2022
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2KYW
| Solution NMR Structure of a domain of adhesion exoprotein from Pediococcus pentosaceus, Northeast Structural Genomics Consortium Target PtR41O | Descriptor: | Adhesion exoprotein | Authors: | He, Y, Eletsky, A, Mills, J.L, Wang, H, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Lee, H.-W, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-09 | Release date: | 2010-08-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of a domain of adhesion exoprotein from Pediococcus pentosaceus, Northeast Structural Genomics Consortium Target PtR41O To be Published
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4C60
| Crystal structure of A. niger ochratoxinase | Descriptor: | OCHRATOXINASE | Authors: | Dobritzsch, D, Wang, H, Schneider, G, Yu, S. | Deposit date: | 2013-09-17 | Release date: | 2014-07-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of Ochratoxinase, a Novel Mycotoxin Degrading Enzyme. Biochem.J., 462, 2014
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3ESH
| Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314 | Descriptor: | Protein similar to metal-dependent hydrolase | Authors: | Seetharaman, J, Chen, Y, Wang, H, Janjua, H, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-10-06 | Release date: | 2008-10-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a probable metal-dependent hydrolase from
Staphylococcus aureus. Northeast Structural Genomics target ZR314 To be Published
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2L7K
| Solution NMR Structure of protein CD1104.2 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 | Descriptor: | Uncharacterized protein | Authors: | Pulavarti, S.V.S.R.K, Eletsky, A, Mills, J.L, Sukumaran, D.K, Wang, H, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-12-13 | Release date: | 2011-02-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of CfR130 from Clostridium difficile, Northeast Structural Genomics Consortium Target CfR130 To be Published
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2LG2
| Structure of the duplex containing HNE derived (6S,8R,11S) N2-dG cyclic hemiacetal when placed opposite dT | Descriptor: | (2R,5S)-5-pentyltetrahydrofuran-2-ol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | Authors: | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | Deposit date: | 2011-07-19 | Release date: | 2012-08-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex To be Published
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6L7R
| Crystal structure of Chaetomium GCP3 N-terminus and Mozart1 | Descriptor: | Mozart1, Putative spindle pole body component alp6 protein | Authors: | Huang, T.L, Wang, H.J, Hsia, K.C. | Deposit date: | 2019-11-02 | Release date: | 2020-07-15 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8481313 Å) | Cite: | Promiscuous Binding of Microprotein Mozart1 to gamma-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation. Cell Rep, 31, 2020
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3LML
| Crystal Structure of the sheath tail protein Lin1278 from Listeria innocua, Northeast Structural Genomics Consortium Target LkR115 | Descriptor: | Lin1278 protein | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Mao, M, Xiao, R, Patel, D.J, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-01-31 | Release date: | 2010-03-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Northeast Structural Genomics Consortium Target LkR115 To be Published
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7C8J
| Structural basis for cross-species recognition of COVID-19 virus spike receptor binding domain to bat ACE2 | Descriptor: | Angiotensin-converting enzyme, SARS-CoV-2 Receptor binding domain, ZINC ION | Authors: | Liu, K.F, Wang, J, Tan, S.G, Niu, S, Wu, L.L, Zhang, Y.F, Pan, X.Q, Meng, Y.M, Chen, Q, Wang, Q.H, Wang, H.W, Qi, J.X, Gao, G.F. | Deposit date: | 2020-06-01 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Cross-species recognition of SARS-CoV-2 to bat ACE2. Proc.Natl.Acad.Sci.USA, 118, 2021
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7C8K
| Structural basis for cross-species recognition of COVID-19 virus spike receptor binding domain to bat ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Liu, K.F, Wang, J, Tan, S.G, Niu, S, Wu, L.L, Zhang, Y.F, Pan, X.Q, Meng, Y.M, Chen, Q, Wang, Q.H, Wang, H.W, Qi, J.X, Gao, G.F. | Deposit date: | 2020-06-02 | Release date: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cross-species recognition of SARS-CoV-2 to bat ACE2. Proc.Natl.Acad.Sci.USA, 118, 2021
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6INR
| The crystal structure of phytoplasmal effector causing phyllody symptoms 1 (PHYL1) | Descriptor: | CADMIUM ION, Putative effector, AYWB SAP54-like protein | Authors: | Liao, Y.T, Lin, S.S, Ko, T.P, Wang, H.C. | Deposit date: | 2018-10-26 | Release date: | 2019-07-31 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural insights into the interaction between phytoplasmal effector causing phyllody 1 and MADS transcription factors. Plant J., 100, 2019
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2MA6
| Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A | Descriptor: | E3 ubiquitin-protein ligase RNF123, ZINC ION | Authors: | Ramelot, T.A, Yang, Y, Janjua, H, Kohan, E, Wang, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-06-28 | Release date: | 2013-07-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A To be Published
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7DDP
| Cryo-EM structure of human ACE2 and GX/P2V/2017 RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Niu, S, Wang, J, Wang, H.W, Qi, J.X, Wang, Q.H, Gao, G.F. | Deposit date: | 2020-10-29 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. Embo J., 40, 2021
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7EG1
| Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex | Descriptor: | (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, MAGNESIUM ION, Schlafen family member 12, ... | Authors: | Liu, N, Chen, J, Wang, X.D, Wang, H.W. | Deposit date: | 2021-03-23 | Release date: | 2021-11-03 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun, 12, 2021
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2MSV
| Solution structure of the MLKL N-terminal domain | Descriptor: | Mixed lineage kinase domain-like protein | Authors: | Su, L, Rizo, J, Quade, B, Wang, H, Sun, L, Wang, X. | Deposit date: | 2014-08-07 | Release date: | 2014-09-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 22, 2014
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2Z1B
| Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs | Descriptor: | Delta-aminolevulinic acid dehydratase | Authors: | Xie, Y, Wang, H, Kawazoe, M, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirozu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-08 | Release date: | 2008-05-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs To be Published
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