1SPS
 
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1SPR
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1SHB
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1SHA
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1TDF
 | | CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, THIOREDOXIN REDUCTASE | | Authors: | Waksman, G, Krishna, T.S.R, Williams Junior, C.H, Kuriyan, J. | | Deposit date: | 1994-01-14 | | Release date: | 1994-11-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.
J.Mol.Biol., 236, 1994
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1TDE
 | | CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, THIOREDOXIN REDUCTASE | | Authors: | Waksman, G, Krishna, T.S.R, Williams Junior, C.H, Kuriyan, J. | | Deposit date: | 1994-01-14 | | Release date: | 1994-11-30 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.
J.Mol.Biol., 236, 1994
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1QTM
 | | DDTTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS | | Descriptor: | 5'-D(*AP*AP*AP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DT))-3', DNA POLYMERASE I, ... | | Authors: | Li, Y, Mitaxov, V, Waksman, G. | | Deposit date: | 1999-06-28 | | Release date: | 1999-08-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 96, 1999
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2PT7
 | | Crystal structure of Cag VirB11 (HP0525) and an inhibitory protein (HP1451) | | Descriptor: | Cag-alfa, Hypothetical protein | | Authors: | Hare, S, Fischer, W, Williams, R, Terradot, L, Bayliss, R, Haas, R, Waksman, G. | | Deposit date: | 2007-05-08 | | Release date: | 2007-11-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase.
Embo J., 26, 2007
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5OH0
 | | The Cryo-Electron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod | | Descriptor: | Type-1 fimbrial protein, A chain | | Authors: | Hospenthal, M.K, Costa, T.R.D, Redzej, A, Waksman, G. | | Deposit date: | 2017-07-13 | | Release date: | 2017-11-22 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod.
Structure, 25, 2017
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8PTU
 | | 2.5 A cryo-EM structure of the in vitro FimD-catalyzed assembly of type 1 pilus rod | | Descriptor: | Type-1 fimbrial protein, A chain | | Authors: | Zyla, D, Hospenthal, M, Glockshuber, R, Waksman, G. | | Deposit date: | 2023-07-14 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.
Nat Commun, 15, 2024
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8PSV
 | | 2.7 A cryo-EM structure of in vitro assembled type 1 pilus rod | | Descriptor: | Type-1 fimbrial protein, A chain | | Authors: | Hospenthal, M, Zyla, D, Glockshuber, R, Waksman, G. | | Deposit date: | 2023-07-13 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.
Nat Commun, 15, 2024
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6QCM
 | | Cryo em structure of the Listeria stressosome | | Descriptor: | RsbR protein, RsbR protein,RsbR protein, RsbS protein | | Authors: | Williams, A.H, Redzej, A, Waksman, G, Cossart, P. | | Deposit date: | 2018-12-28 | | Release date: | 2019-08-21 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.21 Å) | | Cite: | The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.
Nat Commun, 10, 2019
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5CDW
 | | Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide | | Descriptor: | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN | | Authors: | Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. | | Deposit date: | 2015-07-05 | | Release date: | 2016-05-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.602 Å) | | Cite: | Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.
Protein Sci., 25, 2016
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7OIU
 | | Inner Membrane Complex (IMC) protomer structure (TrwM/VirB3, TrwK/VirB4, TrwG/VirB8tails) from the fully-assembled R388 type IV secretion system determined by cryo-EM. | | Descriptor: | TrwG protein, TrwK protein, TrwM protein | | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | | Deposit date: | 2021-05-12 | | Release date: | 2022-06-22 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of a type IV secretion system.
Nature, 607, 2022
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7Q1V
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5FLU
 | | Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin | | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN | | Authors: | Hospenthal, M.K, Redzej, A, Dodson, K, Ukleja, M, Frenz, B, Hultgren, S.J, DiMaio, F, Egelman, E.H, Waksman, G. | | Deposit date: | 2015-10-28 | | Release date: | 2016-01-13 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.
Cell(Cambridge,Mass.), 164, 2016
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6Y7S
 | | 2.85 A cryo-EM structure of the in vivo assembled type 1 pilus rod | | Descriptor: | Type-1 fimbrial protein, A chain | | Authors: | Zyla, D, Hospenthal, M, Waksman, G, Glockshuber, R. | | Deposit date: | 2020-03-02 | | Release date: | 2021-03-31 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.
Nat Commun, 15, 2024
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6SZ9
 | | Type IV Coupling Complex (T4CC) from L. pneumophila. | | Descriptor: | DotY, DotZ, IcmJ (DotN), ... | | Authors: | Mace, K, Meir, A, Lukoyanova, N, Waksman, G. | | Deposit date: | 2019-10-02 | | Release date: | 2020-05-13 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.
Nat Commun, 11, 2020
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7O3V
 | | Stalk complex structure (TrwJ/VirB5-TrwI/VirB6) from the fully-assembled R388 type IV secretion system determined by cryo-EM. | | Descriptor: | TrwI protein, TrwJ protein | | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | | Deposit date: | 2021-04-03 | | Release date: | 2022-06-22 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of a type IV secretion system.
Nature, 607, 2022
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7O3J
 | | O-layer structure (TrwH/VirB7, TrwF/VirB9CTD, TrwE/VirB10CTD) of the outer membrane core complex from the fully-assembled R388 type IV secretion system determined by cryo-EM. | | Descriptor: | TrwE protein, TrwF protein, TrwH protein | | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | | Deposit date: | 2021-04-01 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Cryo-EM structure of a type IV secretion system.
Nature, 607, 2022
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7O3T
 | | I-layer structure (TrwF/VirB9NTD, TrwE/VirB10NTD) of the outer membrane core complex from the fully-assembled R388 type IV secretion system determined by cryo-EM. | | Descriptor: | TrwE protein, TrwF protein | | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | | Deposit date: | 2021-04-03 | | Release date: | 2022-06-22 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of a type IV secretion system.
Nature, 607, 2022
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4AG5
 | | Structure of VirB4 of Thermoanaerobacter pseudethanolicus | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Wallden, K, Williams, R, Yan, J, Lian, P.W, Wang, L, Thalassinos, K, Orlova, E.V, Waksman, G. | | Deposit date: | 2012-01-24 | | Release date: | 2012-07-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structure of the Virb4 ATPase, Alone and Bound to the Core Complex of a Type Iv Secretion System.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4AG6
 | | Structure of VirB4 of Thermoanaerobacter pseudethanolicus | | Descriptor: | SULFATE ION, TYPE IV SECRETORY PATHWAY VIRB4 COMPONENTS-LIKE PROTEIN | | Authors: | Wallden, K, Williams, R, Yan, J, Lian, P.W, Wang, L, Thalassinos, K, Orlova, E.V, Waksman, G. | | Deposit date: | 2012-01-24 | | Release date: | 2012-07-04 | | Last modified: | 2012-07-25 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of the Virb4 ATPase, Alone and Bound to the Core Complex of a Type Iv Secretion System.
Proc.Natl.Acad.Sci.USA, 109, 2012
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7O41
 | | Hexameric composite model of the Inner Membrane Complex (IMC) with the Arches from the fully-assembled R388 type IV secretion system determined by cryo-EM. | | Descriptor: | TrwG protein, TrwK protein, TrwM protein | | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | | Deposit date: | 2021-04-04 | | Release date: | 2022-06-22 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Cryo-EM structure of a type IV secretion system.
Nature, 607, 2022
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7O43
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