7F62
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![BU of 7f62 by Molmil](/molmil-images/mine/7f62) | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody chAb-25 (Focused refinement of S-RBD and chAb-25 region) | Descriptor: | RBD-chAb-25, Heavy chain, Light chain, ... | Authors: | Yang, T.J, Yu, P.Y, Wu, H.C, Hsu, S.T.D. | Deposit date: | 2021-06-24 | Release date: | 2021-08-04 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure-guided antibody cocktail for prevention and treatment of COVID-19. Plos Pathog., 17, 2021
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4LV9
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![BU of 4lv9 by Molmil](/molmil-images/mine/4lv9) | Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | Deposit date: | 2013-07-26 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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7F8T
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![BU of 7f8t by Molmil](/molmil-images/mine/7f8t) | Re-refinement of the 2XRY X-ray structure of archaeal class II CPD photolyase from Methanosarcina mazei | Descriptor: | Deoxyribodipyrimidine photolyase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Maestre-Reyna, M, Yang, C.-H, Huang, W.C, Nango, E, Gusti-Ngurah-Putu, E.-P, Franz-Badur, S, Wu, W.-J, Wu, H.-Y, Wang, P.-H, Liao, J.-H, Lee, C.-C, Huang, K.-F, Chang, Y.-K, Weng, J.-H, Sugahara, M, Owada, S, Joti, Y, Tanaka, R, Tono, K, Kiontke, S, Yamamoto, J, Iwata, S, Essen, L.-O, Bessho, Y, Tsai, M.-D. | Deposit date: | 2021-07-02 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme. Nat.Chem., 14, 2022
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3L42
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![BU of 3l42 by Molmil](/molmil-images/mine/3l42) | PWWP domain of human bromodomain and PHD finger containing protein 1 | Descriptor: | Peregrin, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Zeng, H, Ni, S, Amaya, M.F, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-12-18 | Release date: | 2010-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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3MO8
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![BU of 3mo8 by Molmil](/molmil-images/mine/3mo8) | PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide | Descriptor: | Histone H3.2 TRIMETHYLATED H3K36 PEPTIDE, Peregrin | Authors: | Lam, R, Zeng, H, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-04-22 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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1FLK
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![BU of 1flk by Molmil](/molmil-images/mine/1flk) | MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 | Descriptor: | TNF RECEPTOR ASSOCIATED FACTOR 3 | Authors: | Ni, C.-Z, Welsh, K, Leo, E, Chiou, C.-K, Wu, H, Reed, J.C, Ely, K.R. | Deposit date: | 2000-08-14 | Release date: | 2000-10-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular basis for CD40 signaling mediated by TRAF3. Proc.Natl.Acad.Sci.USA, 97, 2000
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3MOP
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![BU of 3mop by Molmil](/molmil-images/mine/3mop) | The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 | Descriptor: | Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88 | Authors: | Lin, S.-C, Lo, Y.-C, Wu, H. | Deposit date: | 2010-04-23 | Release date: | 2010-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465, 2010
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3M06
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![BU of 3m06 by Molmil](/molmil-images/mine/3m06) | Crystal Structure of TRAF2 | Descriptor: | TNF receptor-associated factor 2 | Authors: | Kabaleeswaran, V, Wu, H. | Deposit date: | 2010-03-02 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol.Cell, 38, 2010
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1LB4
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![BU of 1lb4 by Molmil](/molmil-images/mine/1lb4) | TRAF6 apo structure | Descriptor: | TNF receptor-associated factor 6 | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1LB5
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![BU of 1lb5 by Molmil](/molmil-images/mine/1lb5) | TRAF6-RANK Complex | Descriptor: | TNF receptor-associated factor 6, receptor activator of nuclear factor-kappa B | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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3IHX
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![BU of 3ihx by Molmil](/molmil-images/mine/3ihx) | Methyltransferase domain of human PR domain-containing protein 10 | Descriptor: | PR domain zinc finger protein 10 | Authors: | Amaya, M.F, Dombrovski, L, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-07-31 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Methyltransferase domain of human PR domain-containing protein 10 To be Published
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2F2S
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![BU of 2f2s by Molmil](/molmil-images/mine/2f2s) | Human mitochondrial acetoacetyl-CoA thiolase | Descriptor: | Acetyl-CoA acetyltransferase, mitochondrial, CHLORIDE ION, ... | Authors: | Min, J.R, Dombrovski, L, Antoshenko, T, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2005-11-17 | Release date: | 2005-11-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of Human Mitochondrial Acetoacetyl-Coa Thiolase Acat1. To be Published
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8IMK
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![BU of 8imk by Molmil](/molmil-images/mine/8imk) | D3-D4, D1-D2, D'3-D'4, D'1-D'2 cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster C) | Descriptor: | ApcA1, ApcA2, ApcB1, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IML
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![BU of 8iml by Molmil](/molmil-images/mine/8iml) | Rs2I-Rs2II, Rs1I-Rs1II, RbI-RbII cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster D) | Descriptor: | CpcA, CpcB, CpcD, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IMI
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![BU of 8imi by Molmil](/molmil-images/mine/8imi) | A1-A2, A3-A4, B'1-B'2, C'1-C'2 cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster A) | Descriptor: | ApcA2, ApcB2, ApcB3, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IMJ
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![BU of 8imj by Molmil](/molmil-images/mine/8imj) | A'1-A'2, A'3-A'4, B1-B2, C1-C2 cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster B) | Descriptor: | ApcA2, ApcB2, ApcB3, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IMN
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![BU of 8imn by Molmil](/molmil-images/mine/8imn) | Rt1I-Rt1II, Rt2'I-Rt2'II, Rt3I-Rt3II cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster F) | Descriptor: | CpcA, CpcB, CpcD, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IMM
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![BU of 8imm by Molmil](/molmil-images/mine/8imm) | Rs2'I-Rs2'II, Rs1'I-Rs1'II, Rb'I-Rb'II cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster E) | Descriptor: | CpcA, CpcB, CpcD, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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8IMO
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![BU of 8imo by Molmil](/molmil-images/mine/8imo) | Rt1'I-Rt1'II, Rt2I-Rt2II, Rt3'I-Rt3'II cylinder in cyanobacterial phycobilisome from Anthocerotibacter panamensis (Cluster G) | Descriptor: | CpcA, CpcB, CpcD, ... | Authors: | Wang, C.H, Yang, C.H, Wu, H.Y, Jiang, H.W, Ho, M.C, Ho, M.Y. | Deposit date: | 2023-03-07 | Release date: | 2023-10-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. Nat Commun, 14, 2023
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3B7P
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![BU of 3b7p by Molmil](/molmil-images/mine/3b7p) | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMINE, Spermidine synthase | Authors: | Qiu, W, Dong, A, Ren, H, Wu, H, Zhao, Y, Schapira, M, Wasney, G, Vedadi, M, Lew, J, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Plotnikov, A.N, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2007-10-31 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermine. To be Published
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3RZF
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![BU of 3rzf by Molmil](/molmil-images/mine/3rzf) | Crystal Structure of Inhibitor of kappaB kinase beta (I4122) | Descriptor: | (4-{[4-(4-chlorophenyl)pyrimidin-2-yl]amino}phenyl)[4-(2-hydroxyethyl)piperazin-1-yl]methanone, MGC80376 protein | Authors: | Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H. | Deposit date: | 2011-05-11 | Release date: | 2011-05-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of inhibitor of KappaB kinase Beta. Nature, 472, 2011
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5K22
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![BU of 5k22 by Molmil](/molmil-images/mine/5k22) | |
3C6M
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![BU of 3c6m by Molmil](/molmil-images/mine/3c6m) | Crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMINE, Spermine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Pegg, A.E, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-04 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J.Biol.Chem., 283, 2008
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3C6K
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![BU of 3c6k by Molmil](/molmil-images/mine/3c6k) | Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMIDINE, Spermine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Pegg, A.E, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-04 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J.Biol.Chem., 283, 2008
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1QR6
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![BU of 1qr6 by Molmil](/molmil-images/mine/1qr6) | HUMAN MITOCHONDRIAL NAD(P)-DEPENDENT MALIC ENZYME | Descriptor: | MALIC ENZYME 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Xu, Y, Bhargava, G, Wu, H, Loeber, G, Tong, L. | Deposit date: | 1999-06-18 | Release date: | 1999-07-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases. Structure, 7, 1999
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