7YIM
 
 | | Cryo-EM structure of human Alpha-fetoprotein | | Descriptor: | Alpha-fetoprotein | | Authors: | Liu, N, Liu, K, Wu, C, Liu, Z, Li, M, Wang, J, Wang, H.W. | | Deposit date: | 2022-07-17 | | Release date: | 2023-01-18 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Uniform thin ice on ultraflat graphene for high-resolution cryo-EM.
Nat.Methods, 20, 2023
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1HKS
 | | SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR | | Descriptor: | HEAT-SHOCK TRANSCRIPTION FACTOR | | Authors: | Vuister, G.W, Kim, S.-J, Orosz, A, Marquardt, J.L, Wu, C, Bax, A. | | Deposit date: | 1994-07-18 | | Release date: | 1994-09-30 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.
Nat.Struct.Biol., 1, 1994
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1HKT
 | | SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR | | Descriptor: | HEAT-SHOCK TRANSCRIPTION FACTOR | | Authors: | Vuister, G.W, Kim, S.-J, Orosz, A, Marquardt, J.L, Wu, C, Bax, A. | | Deposit date: | 1994-07-18 | | Release date: | 1994-09-30 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.
Nat.Struct.Biol., 1, 1994
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9B1E
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9B1D
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8WSS
 | | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | | Deposit date: | 2023-10-17 | | Release date: | 2024-06-19 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.
Cell Discov, 10, 2024
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8WST
 | | Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ... | | Authors: | Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C. | | Deposit date: | 2023-10-17 | | Release date: | 2024-06-19 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.
Cell Discov, 10, 2024
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8WW1
 | | Cyclic peptide with affinity for HER3 | | Descriptor: | HER3-1 | | Authors: | Fan, S.H, Wu, C.L. | | Deposit date: | 2023-10-24 | | Release date: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Combinations of Disulfide-Directing Motifs in Tandem Enabling the De-sign and Discovery of Multicyclic Peptide Binders
To Be Published
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8WVS
 | | The structure of CPPCXC motif | | Descriptor: | SER-CYS-PRO-PRO-CYS-LYS-CYS-GLY-TRP | | Authors: | Fan, S.H, Wu, C.L. | | Deposit date: | 2023-10-24 | | Release date: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Combinations of Disulfide-Directing Motifs in Tandem Enabling the De-sign and Discovery of Multicyclic Peptide Binders
To Be Published
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8WW0
 | | Cyclic peptide with affinity for ICOS | | Descriptor: | icos-1 | | Authors: | Fan, S.H, Wu, C.L. | | Deposit date: | 2023-10-24 | | Release date: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Combinations of Disulfide-Directing Motifs in Tandem Enabling the De-sign and Discovery of Multicyclic Peptide Binders
To Be Published
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8BQN
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8IWT
 | | hSPCA1 in the early E2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWR
 | | hSPCA1 in the CaE1-ATP state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWU
 | | hSPCA1 in the E2~P state | | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWW
 | | hSPCA1 in the CaE1P-ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWS
 | | hSPCA1 in the CaE2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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1PJW
 | | Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein | | Descriptor: | envelope protein | | Authors: | Wu, K.P, Wu, C.W, Tsao, Y.P, Lou, Y.C, Lin, C.W. | | Deposit date: | 2003-06-04 | | Release date: | 2003-11-25 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | Structural Basis of a Flavivirus Recognized by Its Neutralizing Antibody: SOLUTION STRUCTURE OF THE DOMAIN III OF THE JAPANESE ENCEPHALITIS VIRUS ENVELOPE PROTEIN.
J.Biol.Chem., 278, 2003
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1XNL
 | | ASLV fusion peptide | | Descriptor: | membrane protein gp37 | | Authors: | Cheng, S.F, Wu, C.W, Kantchev, E.A, Chang, D.K. | | Deposit date: | 2004-10-05 | | Release date: | 2005-01-11 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus
Eur.J.Biochem., 271, 2004
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7RSP
 | | Structure of the VPS34 kinase domain with compound 14 | | Descriptor: | (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3 | | Authors: | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | | Deposit date: | 2021-08-11 | | Release date: | 2021-11-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
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7RSV
 | | Structure of the VPS34 kinase domain with compound 5 | | Descriptor: | (5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | | Authors: | Hu, D.X, Patel, S, Chen, H, Wang, S, Staben, S, Dimitrova, Y.N, Wallweber, H.A, Lee, J.Y, Chan, G.K.Y, Sneeringer, C.J, Prangley, M.S, Moffat, J.G, Wu, C, Schutt, L.K, Salphati, L, Pang, J, McNamara, E, Huang, H, Chen, Y, Wang, Y, Zhao, W, Lim, J, Murthy, A, Siu, M. | | Deposit date: | 2021-08-11 | | Release date: | 2021-11-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
J.Med.Chem., 65, 2022
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2GOH
 | | Three-dimensional Structure of the Trans-membrane Domain of Vpu from HIV-1 in Aligned Phospholipid Bicelles | | Descriptor: | VPU protein | | Authors: | Park, S.H, De Angelis, A.A, Nevzorov, A.A, Wu, C.H, Opella, S.J. | | Deposit date: | 2006-04-12 | | Release date: | 2006-08-08 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Three-Dimensional Structure of the Transmembrane Domain of Vpu from HIV-1 in Aligned Phospholipid Bicelles.
Biophys.J., 91, 2006
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2GOF
 | | Three-dimensional structure of the trans-membrane domain of Vpu from HIV-1 in aligned phospholipid bicelles | | Descriptor: | VPU protein | | Authors: | Park, S.H, De Angelis, A.A, Nevzorov, A.A, Wu, C.H, Opella, S.J. | | Deposit date: | 2006-04-12 | | Release date: | 2006-08-08 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Three-Dimensional Structure of the Transmembrane Domain of Vpu from HIV-1 in Aligned Phospholipid Bicelles.
Biophys.J., 91, 2006
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8EW0
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6KPP
 | | BNC105 in complex with tubulin | | Descriptor: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, T, Wu, C, Pu, D. | | Deposit date: | 2019-08-15 | | Release date: | 2020-08-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.74524117 Å) | | Cite: | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.
Biochem.Biophys.Res.Commun., 2020
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2VXT
 | | Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab | | Descriptor: | CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... | | Authors: | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | | Deposit date: | 2008-07-10 | | Release date: | 2009-06-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.
J.Biol.Chem., 284, 2009
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