8BQN
 
 | |
7V3P
 | | Cryo-EM structure of the IGF1R/insulin complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | | Authors: | Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. | | Deposit date: | 2021-08-11 | | Release date: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the IGF1R/insulin complex
To Be Published
|
|
8SZG
 | | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
|
|
2VXV
 | | Crystal structure of human IgG ABT-325 Fab Fragment | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, GLYCEROL, HUMAN IGG ABT-325 | | Authors: | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | | Deposit date: | 2008-07-10 | | Release date: | 2009-06-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.
J.Biol.Chem., 284, 2009
|
|
2VXT
 | | Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab | | Descriptor: | CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... | | Authors: | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | | Deposit date: | 2008-07-10 | | Release date: | 2009-06-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.
J.Biol.Chem., 284, 2009
|
|
2VXU
 | | Crystal structure of murine reference antibody 125-2H Fab fragment | | Descriptor: | MURINE IGG 125-2H | | Authors: | Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. | | Deposit date: | 2008-07-10 | | Release date: | 2009-06-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.
J.Biol.Chem., 284, 2009
|
|
8SZH
 | | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
|
|
8SZI
 | | Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
|
|
6LN1
 | | A natural inhibitor of DYRK1A for treatment of diabetes mellitus | | Descriptor: | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | Authors: | Li, H, Chen, L.X, Zheng, M.Z, Zhang, Q.Z, Zhang, C.L, Wu, C.R, Yang, K.Y, Song, Z.R, Wang, Q.Q, Li, C, Zhou, Y.R, Chen, J.C. | | Deposit date: | 2019-12-28 | | Release date: | 2021-10-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.699 Å) | | Cite: | A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes.
Clin Transl Med, 11, 2021
|
|
8SZF
 | | Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | He, F, Wu, C, Gao, Y, Skiniotis, G. | | Deposit date: | 2023-05-29 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
|
|
5B7C
 | |
1XPY
 | | Structural Basis for Catalytic Racemization and Substrate Specificity of an N-Acylamino Acid Racemase Homologue from Deinococcus radiodurans | | Descriptor: | MAGNESIUM ION, N-acylamino acid racemase, N~2~-ACETYL-L-GLUTAMINE | | Authors: | Wang, W.-C, Chiu, W.-C, Hsu, S.-K, Wu, C.-L, Chen, C.-Y, Liu, J.-S, Hsu, W.-H. | | Deposit date: | 2004-10-10 | | Release date: | 2004-10-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans
J.Mol.Biol., 342, 2004
|
|
1XS2
 | | Structural Basis for Catalytic Racemization and Substrate Specificity of an N-Acylamino Acid Racemase Homologue from Deinococcus radiodurans | | Descriptor: | MAGNESIUM ION, N-Acylamino Acid Racemase | | Authors: | Wang, W.-C, Chiu, W.-C, Hsu, S.-K, Wu, C.-L, Chen, C.-Y, Liu, J.-S, Hsu, W.-H. | | Deposit date: | 2004-10-18 | | Release date: | 2004-11-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans
J.Mol.Biol., 342, 2004
|
|
3R7C
 | | The structure of a hexahestidine-tagged form of augmenter of liver regeneration reveals a novel Cd(2)Cl(4)O(6) cluster that aids in crystal packing | | Descriptor: | CADMIUM ION, CHLORIDE ION, FAD-linked sulfhydryl oxidase ALR, ... | | Authors: | Florence, Q.J, Wu, C.-K, Swindell II, J.T, Wang, B.C, Rose, J.P. | | Deposit date: | 2011-03-22 | | Release date: | 2012-03-28 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The structure of a hexahestidine-tagged form of augmenter of liver regeneration reveals a novel Cd(2)Cl(4)O(6) cluster that aids in crystal packing
To be Published
|
|
8IWS
 | | hSPCA1 in the CaE2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
|
|
8IWT
 | | hSPCA1 in the early E2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
|
|
8IWR
 | | hSPCA1 in the CaE1-ATP state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
|
|
8IWU
 | | hSPCA1 in the E2~P state | | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
|
|
8IWW
 | | hSPCA1 in the CaE1P-ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
|
|
8EW2
 | |
8F49
 | |
8EW0
 | |
8F7Y
 | |
1R0M
 | | Structure of Deinococcus radiodurans N-acylamino acid racemase at 1.3 : insights into a flexible binding pocket and evolution of enzymatic activity | | Descriptor: | N-acylamino acid racemase | | Authors: | Wang, W.-C, Chiu, W.-C, Hsu, S.-K, Wu, C.-L, Chen, C.-Y, Liu, J.-S, Hsu, W.-H. | | Deposit date: | 2003-09-22 | | Release date: | 2004-09-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans
J.Mol.Biol., 342, 2004
|
|
8GUF
 | |
