1AIU
 
 | | HUMAN THIOREDOXIN (D60N MUTANT, REDUCED FORM) | | 分子名称: | THIOREDOXIN | | 著者 | Andersen, J.F, Gasdaska, J.R, Sanders, D.A.R, Weichsel, A, Powis, G, Montfort, W.R. | | 登録日 | 1997-04-25 | | 公開日 | 1997-07-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.
Biochemistry, 36, 1997
|
|
7SDA
 | |
7SD9
 | |
7SDC
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MI-09 | | 分子名称: | (1R,2S,5S)-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-{[4-(trifluoromethoxy)phenoxy]acetyl}-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | | 著者 | Yang, K.S, Liu, W.R. | | 登録日 | 2021-09-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.
J.Med.Chem., 66, 2023
|
|
1A7E
 | |
5KKD
 | |
2IMQ
 | | Crystal structure of ferrous cimex nitrophorin | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Salivary nitrophorin | | 著者 | Weichsel, A, Montfort, W.R. | | 登録日 | 2006-10-04 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystallographic and spectroscopic characterization of ferrous complexes of cimex nitrophorin, a heme-thiolate protein from the bedbug
To be Published
|
|
7SH7
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI87 | | 分子名称: | 3C-like proteinase nsp5, benzyl [(2S,3R)-3-tert-butoxy-1-{[(2S)-3-cyclohexyl-1-oxo-1-(2-{[(3S)-2-oxopyrrolidin-3-yl]methyl}-2-propanoylhydrazinyl)propan-2-yl]amino}-1-oxobutan-2-yl]carbamate (non-preferred name) | | 著者 | Blankenship, L.R, Yang, K.S, Liu, W.R. | | 登録日 | 2021-10-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease.
Biorxiv, 2023
|
|
7SH9
 | |
7SH8
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI88 | | 分子名称: | 3C-like proteinase nsp5, benzyl [(2S,3R)-1-{[(2S)-1-(2-acetyl-2-{[(3S)-2-oxopyrrolidin-3-yl]methyl}hydrazinyl)-3-cyclohexyl-1-oxopropan-2-yl]amino}-3-tert-butoxy-1-oxobutan-2-yl]carbamate (non-preferred name) | | 著者 | Yang, K.S, Liu, W.R. | | 登録日 | 2021-10-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of the SARS-CoV-2 main protease in complex with inhibitors
To Be Published
|
|
7SHB
 | |
1B8Z
 | | HU FROM THERMOTOGA MARITIMA | | 分子名称: | PROTEIN (HISTONELIKE PROTEIN HU) | | 著者 | Christodoulou, E, Rypniewski, W.R, Vorgias, C.E. | | 登録日 | 1999-02-03 | | 公開日 | 2000-02-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Cloning, overproduction, purification and crystallization of the DNA binding protein HU from the hyperthermophilic eubacterium Thermotoga maritima.
Acta Crystallogr.,Sect.D, 54, 1998
|
|
1AUC
 | | HUMAN THIOREDOXIN (OXIDIZED WITH DIAMIDE) | | 分子名称: | THIOREDOXIN | | 著者 | Anderson, J.F, Sanders, D.A.R, Gasdaska, J, Weichsel, A, Powis, G, Montfort, W.R. | | 登録日 | 1997-08-22 | | 公開日 | 1998-02-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.
Biochemistry, 36, 1997
|
|
2J8W
 | | The crystal structure of cytochrome c' from Rubrivivax gelatinosus at 1.3 A Resolution and pH 8.0 | | 分子名称: | CYTOCHROME C', HEME C | | 著者 | Benini, S, Ciurli, S, Rypniewski, W.R, Wilson, K.S. | | 登録日 | 2006-10-30 | | 公開日 | 2007-11-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | High resolution crystal structure of Rubrivivax gelatinosus cytochrome c'.
J. Inorg. Biochem., 102, 2008
|
|
1BA3
 | | FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM | | 分子名称: | LUCIFERASE, TRIBROMOMETHANE | | 著者 | Franks, N.P, Jenkins, A, Conti, E, Lieb, W.R, Brick, P. | | 登録日 | 1998-04-21 | | 公開日 | 1998-11-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for the inhibition of firefly luciferase by a general anesthetic.
Biophys.J., 75, 1998
|
|
2TSR
 | | THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | | 著者 | Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. | | 登録日 | 1998-06-19 | | 公開日 | 1999-02-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Biochemistry, 38, 1999
|
|
3NSY
 | | The multi-copper oxidase CueO with six Met to Ser mutations (M358S,M361S,M362S,M364S,M366S,M368S) | | 分子名称: | Blue copper oxidase cueO, COPPER (II) ION, CU-O-CU LINKAGE | | 著者 | Roberts, S.A, Montfort, W.R, Singh, S.K. | | 登録日 | 2010-07-02 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.
J. Biol. Chem., 286, 2011
|
|
2HIN
 | | Structure of N15 Cro at 1.05 A: an ortholog of lambda Cro with a completely different but equally effective dimerization mechanism | | 分子名称: | Repressor protein, SULFATE ION | | 著者 | Dubrava, M.S, Ingram, W.M, Roberts, S.A, Weichsel, A, Montfort, W.R, Cordes, M.H. | | 登録日 | 2006-06-29 | | 公開日 | 2007-07-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces.
Protein Sci., 17, 2008
|
|
7TE0
 | | Structure of the SARS-CoV-2 main protease in complex with inhibitor PF-07321332 | | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | | 著者 | Yang, K.S, Liu, W.R. | | 登録日 | 2022-01-03 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir.
J.Med.Chem., 65, 2022
|
|
3NP1
 | | CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE | | 分子名称: | CYANIDE ION, NITROPHORIN 1, PHOSPHATE ION, ... | | 著者 | Weichsel, A, Andersen, J.F, Champagne, D.E, Walker, F.A, Montfort, W.R. | | 登録日 | 1998-01-22 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of a nitric oxide transport protein from a blood-sucking insect.
Nat.Struct.Biol., 5, 1998
|
|
3NN9
 | | REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE N9, ... | | 著者 | Tulip, W.R, Varghese, J.N, Baker, A.T, Vandonkelaar, A, Laver, W.G, Webster, R.G, Colman, P.M. | | 登録日 | 1991-03-28 | | 公開日 | 1992-07-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
J.Mol.Biol., 221, 1991
|
|
3NSC
 | | C500S MUTANT OF CueO BOUND TO Cu(II) | | 分子名称: | ACETATE ION, Blue copper oxidase cueO, COPPER (II) ION, ... | | 著者 | Roberts, S.A, Montfort, W.R, Singh, S.K. | | 登録日 | 2010-07-01 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence.
J. Biol. Chem., 286, 2011
|
|
5KZC
 | | Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Engineered outer domain of gp120, VRC01 Fab heavy chain, ... | | 著者 | Julien, J.-P, Jardine, J.G, Diwanji, D, Schief, W.R, Wilson, I.A. | | 登録日 | 2016-07-24 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Plos Pathog., 12, 2016
|
|
2UBP
 | | STRUCTURE OF NATIVE UREASE FROM BACILLUS PASTEURII | | 分子名称: | NICKEL (II) ION, PROTEIN (UREASE ALPHA SUBUNIT), PROTEIN (UREASE BETA SUBUNIT), ... | | 著者 | Benini, S, Rypniewski, W.R, Wilson, K.S, Ciurli, S, Mangani, S. | | 登録日 | 1998-11-04 | | 公開日 | 1999-11-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels.
Structure Fold.Des., 7, 1999
|
|
1BEI
 | | Shk-dnp22: A Potent Kv1.3-specific immunosuppressive polypeptide, NMR, 20 structures | | 分子名称: | POTASSIUM CHANNEL TOXIN SHK | | 著者 | Kalman, K, Pennington, M.W, Lanigan, M.D, Nguyen, A, Rauer, H, Mahnir, V, Gutman, G.A, Paschetto, K, Kem, W.R, Grissmer, S, Christian, E.P, Cahalan, M.D, Norton, R.S, Chandy, K.G. | | 登録日 | 1998-05-14 | | 公開日 | 1998-12-02 | | 最終更新日 | 2022-12-21 | | 実験手法 | SOLUTION NMR | | 主引用文献 | ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.
J.Biol.Chem., 273, 1998
|
|
