3FFD
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![BU of 3ffd by Molmil](/molmil-images/mine/3ffd) | Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody | Descriptor: | Monoclonal antibody, heavy chain, Fab fragment, ... | Authors: | Mckinstry, W.J, Polekhina, G, Diefenbach-Jagger, H, Ho, P.W.M, Sato, K, Onuma, E, Gillespie, M.T, Martin, T.J, Parker, M.W. | Deposit date: | 2008-12-03 | Release date: | 2009-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor J.Biol.Chem., 284, 2009
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3E4A
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![BU of 3e4a by Molmil](/molmil-images/mine/3e4a) | Human IDE-inhibitor complex at 2.6 angstrom resolution | Descriptor: | 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ... | Authors: | Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J. | Deposit date: | 2008-08-11 | Release date: | 2009-05-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One, 5, 2010
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4AYC
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![BU of 4ayc by Molmil](/molmil-images/mine/4ayc) | RNF8 RING domain structure | Descriptor: | CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF8, GLYCEROL, ... | Authors: | Mattiroli, F, Vissers, J.H.A, Van Dijk, W.J, Ikpa, P, Citterio, E, Vermeulen, W, Marteijn, J.A, Sixma, T.K. | Deposit date: | 2012-06-20 | Release date: | 2012-09-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rnf168 Ubiquitinates K13-15 on H2A/H2Ax to Drive DNA Damage Signaling Cell(Cambridge,Mass.), 150, 2012
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2KWQ
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![BU of 2kwq by Molmil](/molmil-images/mine/2kwq) | Mcm10 C-terminal DNA binding domain | Descriptor: | Protein MCM10 homolog, ZINC ION | Authors: | Robertson, P.D, Chagot, B, Chazin, W.J, Eichman, B.F. | Deposit date: | 2010-04-15 | Release date: | 2010-05-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif. J.Biol.Chem., 285, 2010
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4EGH
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![BU of 4egh by Molmil](/molmil-images/mine/4egh) | |
4EGK
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![BU of 4egk by Molmil](/molmil-images/mine/4egk) | Human Hsp90-alpha ATPase domain bound to Radicicol | Descriptor: | Heat shock protein HSP 90-alpha, RADICICOL | Authors: | Chen, W.J, Wood, S.P. | Deposit date: | 2012-03-31 | Release date: | 2012-05-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17, 2012
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2LA1
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![BU of 2la1 by Molmil](/molmil-images/mine/2la1) | Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin | Descriptor: | Mambin | Authors: | Chuang, W.J, Cheng, C.H, Chen, Y.C, Shiu, J.H. | Deposit date: | 2011-03-01 | Release date: | 2012-03-07 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition Protein Sci., 21, 2012
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4CCW
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![BU of 4ccw by Molmil](/molmil-images/mine/4ccw) | Crystal structure of naproxen esterase (carboxylesterase NP) from Bacillus subtilis | Descriptor: | (2-hydroxyethoxy)acetic acid, CARBOXYL ESTERASE NP | Authors: | Rozeboom, H.J, Godinho, L.F, Nardini, M, Quax, W.J, Dijkstra, B.W. | Deposit date: | 2013-10-29 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structures of Two Bacillus Carboxylesterases with Different Enantioselectivities. Biochim.Biophys.Acta, 1844, 2014
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4CCY
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![BU of 4ccy by Molmil](/molmil-images/mine/4ccy) | Crystal structure of carboxylesterase CesB (YbfK) from Bacillus subtilis | Descriptor: | CARBOXYLESTERASE YBFK, SODIUM ION | Authors: | Rozeboom, H.J, Godinho, L.F, Nardini, M, Quax, W.J, Dijkstra, B.W. | Deposit date: | 2013-10-29 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal Structures of Two Bacillus Carboxylesterases with Different Enantioselectivities. Biochim.Biophys.Acta, 1844, 2014
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2L53
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![BU of 2l53 by Molmil](/molmil-images/mine/2l53) | |
4EGI
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![BU of 4egi by Molmil](/molmil-images/mine/4egi) | Hsp90-alpha ATPase domain in complex with 2-Amino-4-ethylthio-6-methyl-1,3,5-triazine | Descriptor: | 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Chen, W.J, Wood, S.P. | Deposit date: | 2012-03-31 | Release date: | 2012-05-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17, 2012
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2M0X
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4BTH
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![BU of 4bth by Molmil](/molmil-images/mine/4bth) | The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains | Descriptor: | ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, GLYCEROL | Authors: | Koch, G, Nadal-Jimenez, P, Reis, C.R, Muntendam, R, Bokhove, M, Melillo, E, Dijkstra, B.W, Cool, R.H, Quax, W.J. | Deposit date: | 2013-06-18 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq Proc.Natl.Acad.Sci.USA, 111, 2014
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2MB3
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![BU of 2mb3 by Molmil](/molmil-images/mine/2mb3) | Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative | Descriptor: | (12S,27S)-12,27-bis(4-aminobutyl)-4,30-dimethyl-3,7,14,18,22,29-hexaoxa-11,26,31,32,33,34,35,36-octaazaheptacyclo[26.2. 1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]hexatriaconta-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-dode caene-10,25-dione, DNA_(5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*A)-3') | Authors: | Chung, W.J, Heddi, B, Tera, M, Iida, K, Nagasawa, K, Phan, A.T. | Deposit date: | 2013-07-24 | Release date: | 2013-08-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of an intramolecular (3 + 1) human telomeric g-quadruplex bound to a telomestatin derivative. J.Am.Chem.Soc., 135, 2013
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2M4N
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![BU of 2m4n by Molmil](/molmil-images/mine/2m4n) | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans | Descriptor: | Protein AFD-1, isoform a | Authors: | Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Seidel, R.D, Liddington, R.C, Weis, W.I, Nelson, W.J, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | Deposit date: | 2013-02-07 | Release date: | 2013-03-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans To be Published
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2MGN
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![BU of 2mgn by Molmil](/molmil-images/mine/2mgn) | Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 | Descriptor: | 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3', N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide | Authors: | Chung, W.J, Heddi, B, Hamon, F, Teulade-Fichou, M.P, Phan, A.T. | Deposit date: | 2013-11-01 | Release date: | 2014-01-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3. Angew.Chem.Int.Ed.Engl., 53, 2014
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4D59
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![BU of 4d59 by Molmil](/molmil-images/mine/4d59) | Clostridial Cysteine protease Cwp84 C116A after propeptide cleavage | Descriptor: | CALCIUM ION, CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | Authors: | Bradshaw, W.J, Roberts, A.K, Shone, C.C, Acharya, K.R. | Deposit date: | 2014-11-03 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Cwp84, a Clostridium Difficile Cysteine Protease, Exhibits Conformational Flexibility in the Absence of its Propeptide Acta Crystallogr.,Sect.F, 71, 2015
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4D5A
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![BU of 4d5a by Molmil](/molmil-images/mine/4d5a) | Clostridial Cysteine protease Cwp84 C116A after propeptide cleavage | Descriptor: | CALCIUM ION, CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), GLYCEROL, ... | Authors: | Bradshaw, W.J, Roberts, A.K, Shone, C.C, Acharya, K.R. | Deposit date: | 2014-11-03 | Release date: | 2015-03-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Cwp84, a Clostridium Difficile Cysteine Protease, Exhibits Conformational Flexibility in the Absence of its Propeptide Acta Crystallogr.,Sect.F, 71, 2015
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2N3M
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4DPU
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![BU of 4dpu by Molmil](/molmil-images/mine/4dpu) | |
4DZY
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![BU of 4dzy by Molmil](/molmil-images/mine/4dzy) | Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with ADP | Descriptor: | (S)-2-chloro-3-phenylpropanoic acid, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | Deposit date: | 2012-03-01 | Release date: | 2013-03-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110, 2013
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4DFF
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![BU of 4dff by Molmil](/molmil-images/mine/4dff) | The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia | Descriptor: | 8,9-dimethoxy-1-(1,3-thiazol-5-yl)-5,6-dihydroimidazo[5,1-a]isoquinoline, MAGNESIUM ION, ZINC ION, ... | Authors: | Ho, G.D, Seganish, W.M, Bercovici, A, Tulshian, D, Greenlee, W.J, Van Rijn, R, Hruza, A, Xiao, L, Rindgen, D, Mullins, D, Guzzi, M, Zhang, X, Bleichardt, C, Hodgson, R. | Deposit date: | 2012-01-23 | Release date: | 2012-03-14 | Last modified: | 2012-04-04 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 22, 2012
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2MS9
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![BU of 2ms9 by Molmil](/molmil-images/mine/2ms9) | Solution structure of a G-quadruplex | Descriptor: | DNA (28-MER) | Authors: | Chung, W.J, Heddi, B, Schmitt, E, Lim, K.W, Mechulam, Y, Phan, A.T. | Deposit date: | 2014-07-25 | Release date: | 2015-02-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of a left-handed DNA G-quadruplex Proc.Natl.Acad.Sci.USA, 2015
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4DPX
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2N59
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![BU of 2n59 by Molmil](/molmil-images/mine/2n59) | Solution Structure of R. palustris CsgH | Descriptor: | Putative uncharacterized protein CsgH | Authors: | Hawthorne, W.J, Taylor, J.D, Escalera-Maurer, A, Lambert, S, Koch, M, Scull, N, Sefer, L, Xu, Y, Matthews, S.J. | Deposit date: | 2015-07-13 | Release date: | 2016-05-11 | Method: | SOLUTION NMR | Cite: | Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones. Sci Rep, 6, 2016
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