4EGH
Hsp90-alpha ATPase domain in complex with (4-Hydroxyphenyl)morpholin-4-yl methanone
Summary for 4EGH
| Entry DOI | 10.2210/pdb4egh/pdb |
| Related | 4EGI 4EGK |
| Descriptor | Heat shock protein HSP 90-alpha, MAGNESIUM ION, (4-hydroxyphenyl)(morpholin-4-yl)methanone, ... (4 entities in total) |
| Functional Keywords | bergerat fold, hydrolase, atp binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P07900 |
| Total number of polymer chains | 1 |
| Total formula weight | 26301.77 |
| Authors | Chen, W.J.,Wood, S.P. (deposition date: 2012-03-30, release date: 2012-05-23, Last modification date: 2024-02-28) |
| Primary citation | Austin, C.,Pettit, S.N.,Magnolo, S.K.,Sanvoisin, J.,Chen, W.,Wood, S.P.,Freeman, L.D.,Pengelly, R.J.,Hughes, D.E. Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17:868-876, 2012 Cited by PubMed: 22573733DOI: 10.1177/1087057112445785 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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