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PDB: 1306 件
1OTP
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STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE
分子名称: THYMIDINE PHOSPHORYLASE
著者Pugmire, M.J, Cook, W.J, Jasanoff, A, Walter, M.R, Ealick, S.E.
登録日1997-11-09
公開日1998-12-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
J.Mol.Biol., 281, 1998
4E58
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Crystal structure of GCC(LCG)CCGC duplex containing LNA residue
分子名称: RNA duplex containing CCG repeats, SULFATE ION
著者Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, R.
登録日2012-03-14
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.952 Å)
主引用文献Crystallographic characterization of CCG repeats.
Nucleic Acids Res., 40, 2012
1N66
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Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR
分子名称: internal loop in the Y-domain of poliovirus 3'UTR
著者Lescrinier, E.M, Tessari, M, van Kuppeveld, F.J, Melchers, W.J, Hilbers, C.W, Heus, H.A.
登録日2002-11-08
公開日2003-08-19
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the Pyrimidine-rich Internal Loop in the Poliovirus 3'-UTR: The Importance of Maintaining Pseudo-2-fold Symmetry in RNA Helices Containing Two Adjacent Non-canonical Base-pairs.
J.Mol.Biol., 331, 2003
6K7U
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Crystal structure of beta-2 microglobulin (beta2m) of Bat (Pteropus Alecto)
分子名称: Bat beta-2-microglobulin
著者Lu, D, Liu, K.F, Zhang, D, Yue, C, Lu, Q, Cheng, H, Chai, Y, Qi, J.X, Gao, F.G, Liu, W.J.
登録日2019-06-08
公開日2019-09-18
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.
Plos Biol., 17, 2019
1N87
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Solution structure of the U-box of Prp19
分子名称: Pre-mRNA splicing factor PRP19
著者Chazin, W.J, Ohi, M.D, Vander Kooi, C.W.
登録日2002-11-19
公開日2003-04-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural insights into the U-box, a domain associated with multi-ubiquitination
Nat.Struct.Biol., 10, 2003
1RSD
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DHNA complex with 3-(5-Amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethyl-phenylsulfanyl)-benzyl]-benzamide
分子名称: 3-(5-AMINO-7-HYDROXY-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-2-YL)-N-[2-(2-(HYDROXYMETHYL-PHENYLSULFANYL)-BENZYL]-BENZAMIDE, Dihydroneopterin aldolase
著者Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RL1
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Solution structure of human Sgt1 CS domain
分子名称: Suppressor of G2 allele of SKP1 homolog
著者Lee, Y.-T, Jacob, J, Michowski, W, Nowotny, M, Kuznicki, J, Chazin, W.J.
登録日2003-11-24
公開日2004-05-04
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Human Sgt1 Binds HSP90 through the CHORD-Sgt1 Domain and Not the Tetratricopeptide Repeat Domain
J.Biol.Chem., 279, 2004
1R50
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Bacillus subtilis lipase A with covalently bound Sc-IPG-phosphonate-inhibitor
分子名称: Lipase, [(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE
著者Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J.
登録日2003-10-09
公開日2004-10-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection
Chembiochem, 7, 2005
1RRW
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DHNA complexed with 9-methylguanine
分子名称: 9-METHYLGUANINE, Dihydroneopterin aldolase
著者Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1RS2
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DHNA complex with 8-Amino-1,3-dimethyl-3,7-dihydropurine-2,6-dione
分子名称: 8-AMINO-1,3-DIMETHYL-3,7-DIHYDROPURINE-2,6-DIONE, Dihydroneopterin aldolase
著者Sanders, W.J, Nienaber, V.L, Lerner, C.G, McCall, J.O, Merrick, S.M, Swanson, S.J, Harlan, J.E, Stoll, V.S, Stamper, G.F, Betz, S.F, Condroski, K.R, Meadows, R.P, Severin, J.M, Walter, K.A, Magdalinos, P, Jakob, C.G, Wagner, R, Beutel, B.A.
登録日2003-12-09
公開日2004-03-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization.
J.Med.Chem., 47, 2004
1Q7J
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Structural Analysis of Integrin alpha IIb beta 3- Disintegrin with the AKGDWN Motif
分子名称: Hemorrhagic protein-rhodostomin
著者Chuang, W.J, Chen, C.Y, Shiu, J.H, Chen, Y.C.
登録日2003-08-19
公開日2004-09-21
最終更新日2021-11-10
実験手法SOLUTION NMR
主引用文献Structure Analysis of Integrin alpha IIb beta 3 - Specific Disintegrin with the AKGDWN Motif
To be Published
6HNJ
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The ligand-bound, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile.
分子名称: 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ...
著者Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R.
登録日2018-09-15
公開日2019-08-28
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
1SQT
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BU of 1sqt by Molmil
Substituted 2-Naphthamidine Inhibitors of Urokinase
分子名称: 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE, Urokinase-type plasminogen activator
著者Wendt, M.D, Geyer, A, McClellan, W.J, Rockway, T.W, Weitzberg, M, Zhang, X, Mantei, R, Stewart, K, Nienaber, V, Klinghofer, V, Giranda, V.L.
登録日2004-03-19
公開日2004-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
1RZY
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BU of 1rzy by Molmil
Crystal structure of rabbit Hint complexed with N-ethylsulfamoyladenosine
分子名称: 5'-O-(N-ETHYL-SULFAMOYL)ADENOSINE, Histidine triad nucleotide-binding protein 1
著者Krakowiak, A.K, Pace, H.C, Blackburn, G.M, Adams, M, Mekhalfia, A, Kaczmarek, R, Baraniak, J, Stec, W.J, Brenner, C.
登録日2003-12-29
公開日2004-03-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors
J.Biol.Chem., 279, 2004
6HQ9
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Crystal structure of the Tudor domain of human ERCC6-L2
分子名称: DNA excision repair protein ERCC-6-like 2
著者Newman, J.A, Gavard, A.E, Nathan, W.J, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2018-09-24
公開日2018-10-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.982 Å)
主引用文献Crystal structure of the Tudor domain of human ERCC6-L2
To Be Published
4EO6
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HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres
分子名称: 5-(3,3-dimethylbut-1-yn-1-yl)-3-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}thiophene-2-carboxylic acid, RNA-directed RNA polymerase
著者Appleby, T.C, Canales, E, Watkins, W.J.
登録日2012-04-13
公開日2012-06-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.791 Å)
主引用文献Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4DPY
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Crystal structure of Staphylococcus epidermidis S192A mevalonate diphosphate decarboxylase complexed with inhibitor DPGP
分子名称: 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline, Mevalonate diphosphate decarboxylase
著者Barta, M.L, McWhorter, W.J, Geisbrecht, B.V.
登録日2012-02-14
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
Biochemistry, 51, 2012
4DU7
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Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with substrate mevalonate diphosphate
分子名称: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, FORMIC ACID, Mevalonate diphosphate decarboxylase
著者Barta, M.L, McWhorter, W.J, Geisbrecht, B.V.
登録日2012-02-21
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
Biochemistry, 51, 2012
4E01
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Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with AMPPNP
分子名称: 3,6-dichloro-1-benzothiophene-2-carboxylic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T.
登録日2012-03-02
公開日2013-03-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes
To be Published
4E00
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Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP
分子名称: 3,6-dichloro-1-benzothiophene-2-carboxylic acid, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T.
登録日2012-03-01
公開日2013-03-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP
To be Published
6IPE
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Post-catalytic Complex of Human DNA Polymerase Mu with Templating Adenine and Mg-8oxodGMP
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ...
著者Chang, Y.K, Wu, W.J, Tsai, M.D.
登録日2018-11-03
公開日2019-05-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
6IPK
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Binary Complex of Human DNA Polymerase Mu with Mn8oxodGTP
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, ...
著者Chang, Y.K, Wu, W.J, Tsai, M.D.
登録日2018-11-03
公開日2019-05-29
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
1SQO
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Substituted 2-Naphthamidine Inhibitors of Urokinase
分子名称: 8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE, SULFATE ION, Urokinase-type plasminogen activator
著者Wendt, M.D, Geyer, A, McClellan, W.J, Rockway, T.W, Weitzberg, M, Zhao, X, Mantei, R, Stewart, K, Nienaber, V, Klinghofer, V, Giranda, V.L.
登録日2004-03-19
公開日2004-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
1SK6
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Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin, ...
著者Guo, Q, Shen, Y, Zhukovskaya, N.L, Tang, W.J.
登録日2004-03-04
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
J.Biol.Chem., 279, 2004
4E59
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Crystal structure of GCCGCCGC duplex
分子名称: RNA duplex containing CCG repeats
著者Kiliszek, A, Kierzek, R, Krzyzosiak, W.J, Rypniewski, W.
登録日2012-03-14
公開日2012-12-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Crystallographic characterization of CCG repeats.
Nucleic Acids Res., 40, 2012

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