7RWC
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![BU of 7rwc by Molmil](/molmil-images/mine/7rwc) | AP2 bound to the APA domain of SGIP and heparin; partial signal subtraction and symmetry expansion | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | Deposit date: | 2021-08-19 | Release date: | 2022-03-30 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization. Nat.Struct.Mol.Biol., 29, 2022
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7SEZ
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![BU of 7sez by Molmil](/molmil-images/mine/7sez) | Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with m7GDP | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, DNA repair NTP-phosphohydrolase, SODIUM ION | Authors: | Peters, J.K, Tibble, R.W, Warminski, M, Jemielity, J, Gross, J.D. | Deposit date: | 2021-10-02 | Release date: | 2022-03-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.70001245 Å) | Cite: | Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. Structure, 30, 2022
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7SF0
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![BU of 7sf0 by Molmil](/molmil-images/mine/7sf0) | Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with trinucleotide substrate | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, DNA repair NTP-phosphohydrolase, MAGNESIUM ION, ... | Authors: | Peters, J.K, Tibble, R.W, Warminski, M, Jemielity, J, Gross, J.D. | Deposit date: | 2021-10-02 | Release date: | 2022-03-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95000446 Å) | Cite: | Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. Structure, 30, 2022
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7SH6
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4UQH
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![BU of 4uqh by Molmil](/molmil-images/mine/4uqh) | Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(3,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide. | Descriptor: | (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(3,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE, ... | Authors: | Calvet, C.M, Vieira, D.F, Choi, J.Y, Cameron, M.D, Gut, J, Kellar, D, Siqueira-Neto, J.L, McKerrow, J.H, Roush, W.R, Podust, L.M. | Deposit date: | 2014-06-23 | Release date: | 2014-08-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | 4-Aminopyridyl-Based Cyp51 Inhibitors as Anti-Trypanosoma Cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency. J.Med.Chem., 57, 2014
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7RWB
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![BU of 7rwb by Molmil](/molmil-images/mine/7rwb) | AP2 bound to the APA domain of SGIP in the presence of heparin | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | Deposit date: | 2021-08-19 | Release date: | 2022-03-30 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization. Nat.Struct.Mol.Biol., 29, 2022
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4V0I
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![BU of 4v0i by Molmil](/molmil-images/mine/4v0i) | Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta | Descriptor: | 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM | Authors: | Robinson, D, Bertrand, T, Carry, J.C, Halley, F, Karlsson, A, Mathieu, M, Minoux, H, Perrin, M.A, Robert, B, Schio, L, Sherman, W. | Deposit date: | 2014-09-16 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications. J.Chem.Inf.Model., 56, 2016
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7SBF
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![BU of 7sbf by Molmil](/molmil-images/mine/7sbf) | PZM21 bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B. | Deposit date: | 2021-09-24 | Release date: | 2022-04-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists. Angew.Chem.Int.Ed.Engl., 61, 2022
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4W5U
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7S3Q
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![BU of 7s3q by Molmil](/molmil-images/mine/7s3q) | NMR Solution Structure of hGal(1-12)KK, a solubility-tagged truncation of the human neuropeptide galanin | Descriptor: | Galanin | Authors: | Kraichely, K.N, Hendy, C.M, Parnham, S, Giuliano, M.W. | Deposit date: | 2021-09-08 | Release date: | 2022-05-25 | Last modified: | 2022-07-06 | Method: | SOLUTION NMR | Cite: | Minimal Increments of Hydrophobic Collapse within the N-Terminus of the Neuropeptide Galanin. Biochemistry, 61, 2022
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7S3O
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![BU of 7s3o by Molmil](/molmil-images/mine/7s3o) | NMR Solution Structure of hGal(2-12)KK, a solubility-tagged truncation of the human neuropeptide galanin | Descriptor: | Galanin | Authors: | Kraichely, K.N, Clinkscales, S.E, Parnham, S, Giuliano, M.W. | Deposit date: | 2021-09-07 | Release date: | 2022-05-25 | Last modified: | 2022-07-06 | Method: | SOLUTION NMR | Cite: | Minimal Increments of Hydrophobic Collapse within the N-Terminus of the Neuropeptide Galanin. Biochemistry, 61, 2022
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7S3R
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![BU of 7s3r by Molmil](/molmil-images/mine/7s3r) | NMR Solution Structure of hGal(1-12)KK, a solubility-tagged truncation of the human neuropeptide galanin | Descriptor: | Galanin | Authors: | Kraichely, K.N, Mendoza, E.A, Parnham, S, Giuliano, M.W. | Deposit date: | 2021-09-08 | Release date: | 2022-05-25 | Last modified: | 2022-07-06 | Method: | SOLUTION NMR | Cite: | Minimal Increments of Hydrophobic Collapse within the N-Terminus of the Neuropeptide Galanin. Biochemistry, 61, 2022
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4W8T
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7SK2
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![BU of 7sk2 by Molmil](/molmil-images/mine/7sk2) | Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation | Descriptor: | Sodium- and chloride-dependent GABA transporter 1, Tiagabine | Authors: | Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V. | Deposit date: | 2021-10-19 | Release date: | 2022-06-08 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structural basis of GABA reuptake inhibition. Nature, 606, 2022
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4WB0
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7SKW
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![BU of 7skw by Molmil](/molmil-images/mine/7skw) | Ab initio structure of triclinic lysozyme from electron-counted MicroED data | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (0.87 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
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7SKX
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![BU of 7skx by Molmil](/molmil-images/mine/7skx) | Ab initio structure of proteinase K from electron-counted MicroED data | Descriptor: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, Proteinase K | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
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4UV3
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![BU of 4uv3 by Molmil](/molmil-images/mine/4uv3) | Structure of the curli transport lipoprotein CsgG in its membrane- bound conformation | Descriptor: | CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG | Authors: | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | Deposit date: | 2014-08-04 | Release date: | 2014-09-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg. Nature, 516, 2014
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4W7H
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![BU of 4w7h by Molmil](/molmil-images/mine/4w7h) | Crystal Structure of DEH Reductase A1-R Mutant | Descriptor: | Carbonyl reductase | Authors: | Takase, R, Mikami, B, Kawai, S, Murata, K, Hashimoto, W. | Deposit date: | 2014-08-22 | Release date: | 2014-09-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structure-based Conversion of the Coenzyme Requirement of a Short-chain Dehydrogenase/Reductase Involved in Bacterial Alginate Metabolism. J.Biol.Chem., 289, 2014
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4W8J
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![BU of 4w8j by Molmil](/molmil-images/mine/4w8j) | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals | Descriptor: | CALCIUM ION, POTASSIUM ION, Pesticidal crystal protein cry1Ac | Authors: | Evdokimov, A.G, Moshiri, F, Sturman, E.J, Rydel, T.J, Zheng, M, Seale, J.W, Franklin, S. | Deposit date: | 2014-08-25 | Release date: | 2014-09-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals. Protein Sci., 23, 2014
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4WB8
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![BU of 4wb8 by Molmil](/molmil-images/mine/4wb8) | Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. | Deposit date: | 2014-09-02 | Release date: | 2015-01-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
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4URD
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![BU of 4urd by Molmil](/molmil-images/mine/4urd) | Cryo-EM map of Trigger Factor bound to a translating ribosome | Descriptor: | TRIGGER FACTOR | Authors: | Deeng, J, Chan, K.Y, van der Sluis, E, Bischoff, L, Berninghausen, O, Han, W, Gumbart, J, Schulten, K, Beatrix, B, Beckmann, R. | Deposit date: | 2014-06-27 | Release date: | 2016-01-13 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Dynamic Behavior of Trigger Factor on the Ribosome. J.Mol.Biol., 428, 2016
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4URS
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![BU of 4urs by Molmil](/molmil-images/mine/4urs) | Crystal Structure of GGDEF domain from T.maritima | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DIGUANYLATE CYCLASE, ... | Authors: | Deepthi, A, Liew, C.W, Liang, Z.X, Swaminathan, K, Lescar, J. | Deposit date: | 2014-07-02 | Release date: | 2014-10-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structure of a Diguanylate Cyclase from Thermotoga Maritima: Insights Into Activation, Feedback Inhibition and Thermostability Plos One, 9, 2014
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4UVR
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![BU of 4uvr by Molmil](/molmil-images/mine/4uvr) | Binding mode, selectivity and potency of N-indolyl-oxopyridinyl-4- amino-propanyl-based inhibitors targeting Trypanosoma cruzi CYP51 | Descriptor: | Nalpha-{4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-fluorobenzoyl}-N-pyridin-4-yl-D-tryptophanamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-DEMETHYLASE, ... | Authors: | Vieira, D.F, Choi, J.Y, Calvet, C.M, Gut, J, Kellar, D, Siqueira-Neto, J.L, Johnston, J.B, McKerrow, J.H, Roush, W.R, Podust, L.M. | Deposit date: | 2014-08-08 | Release date: | 2014-11-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 J.Med.Chem., 57, 2014
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7S7J
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![BU of 7s7j by Molmil](/molmil-images/mine/7s7j) | Structure of Human SPASTIN-IST1 complex. | Descriptor: | CALCIUM ION, CHLORIDE ION, IST1 homolog, ... | Authors: | Skalicky, J.J, Sundquist, W.I. | Deposit date: | 2021-09-16 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. Elife, 11, 2022
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