3V5U
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![BU of 3v5u by Molmil](/molmil-images/mine/3v5u) | Structure of Sodium/Calcium Exchanger from Methanocaldococcus jannaschii DSM 2661 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ACETATE ION, CALCIUM ION, ... | Authors: | Jiang, Y, Liao, J, Li, H, Zeng, W, Sauer, D, Belmares, R. | Deposit date: | 2011-12-16 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science, 335, 2012
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8YKX
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![BU of 8ykx by Molmil](/molmil-images/mine/8ykx) | Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | Deposit date: | 2024-03-05 | Release date: | 2024-05-29 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell Res., 34, 2024
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8X0J
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![BU of 8x0j by Molmil](/molmil-images/mine/8x0j) | old yellow enzymes-Q102A/Y169F/R215A/R308A | Descriptor: | NADPH dehydrogenase, PHOSPHATE ION | Authors: | Lei, W, Wei, S. | Deposit date: | 2023-11-04 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Unlocking the function promiscuity of old yellow enzyme to catalyze asymmetric Morita-Baylis-Hillman reaction To Be Published
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8WWX
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8VHW
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![BU of 8vhw by Molmil](/molmil-images/mine/8vhw) | Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD | Descriptor: | HYDROGEN PEROXIDE, MANGANESE (II) ION, Superoxide dismutase [Mn], ... | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Coates, L, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | Deposit date: | 2024-01-02 | Release date: | 2024-07-31 | Method: | NEUTRON DIFFRACTION (2.3 Å) | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition. Biorxiv, 2024
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9AUO
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![BU of 9auo by Molmil](/molmil-images/mine/9auo) | Structure of SARS-CoV-2 Mpro mutant (L50F,T304I) | Descriptor: | 3C-like proteinase nsp5 | Authors: | Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E. | Deposit date: | 2024-02-29 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.423 Å) | Cite: | In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Sci Adv, 10, 2024
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8XPG
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![BU of 8xpg by Molmil](/molmil-images/mine/8xpg) | The Crystal Structure of polo box domain of Plk4 from Biortus. | Descriptor: | SULFATE ION, Serine/threonine-protein kinase PLK4 | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B. | Deposit date: | 2024-01-03 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Crystal Structure of polo box domain of Plk4 from Biortus. To Be Published
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9ERY
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![BU of 9ery by Molmil](/molmil-images/mine/9ery) | Co-crystal strucutre of PD-L1 with low molecular weight inhibitor | Descriptor: | 5-[[5-[[2-[bis(fluoranyl)methyl]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]methoxy]-2-[(2-hydroxyethylamino)methyl]phenoxy]methyl]pyridine-3-carbonitrile, Programmed cell death 1 ligand 1, SULFATE ION | Authors: | Plewka, J, Magiera-Mularz, K, Zhang, W. | Deposit date: | 2024-03-25 | Release date: | 2024-07-24 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Design, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-l1 inhibitors. Eur.J.Med.Chem., 276, 2024
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8XPX
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![BU of 8xpx by Molmil](/molmil-images/mine/8xpx) | The Crystal Structure of PARP12 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, F, Cheng, W, Lv, Z, Qi, J, Shen, Z. | Deposit date: | 2024-01-04 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The Crystal Structure of PARP12 from Biortus. To Be Published
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8XB4
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4V0T
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![BU of 4v0t by Molmil](/molmil-images/mine/4v0t) | Monomeric pseudorabies virus protease pUL26N at 2.1 A resolution | Descriptor: | UL26 | Authors: | Zuehlsdorf, M, Werten, S, Palm, G.J, Hinrichs, W. | Deposit date: | 2014-09-18 | Release date: | 2015-07-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin Pul26N, a Herpesvirus Serine Protease Plos Pathog., 11, 2015
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1HN9
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![BU of 1hn9 by Molmil](/molmil-images/mine/1hn9) | CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III | Descriptor: | BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, PHOSPHATE ION | Authors: | Qiu, X, Janson, C.A, Konstantinidis, A.K, Nwagwu, S, Silverman, C, Smith, W.W, Khandekar, S.K, Lonsdale, J, Abdel-Meguid, S.S. | Deposit date: | 2000-12-07 | Release date: | 2000-12-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis. J.Biol.Chem., 274, 1999
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8YF7
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8VJ5
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![BU of 8vj5 by Molmil](/molmil-images/mine/8vj5) | Peroxide-Soaked MnSOD | Descriptor: | HYDROGEN PEROXIDE, MANGANESE (II) ION, PHOSPHATE ION, ... | Authors: | Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O. | Deposit date: | 2024-01-05 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition. Biorxiv, 2024
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9B94
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9BOR
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![BU of 9bor by Molmil](/molmil-images/mine/9bor) | IkappaBzeta ankyrin repeat domain:NF-kappaB p50 homodimer complex at 2.0 Angstrom resolution | Descriptor: | (2R,3S)-heptane-1,2,3-triol, NF-kappa-B inhibitor zeta, Nuclear factor NF-kappa-B p50 subunit | Authors: | Rogers, W.E, Zhu, N, Huxford, T. | Deposit date: | 2024-05-05 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structural and biochemical analyses of the nuclear I kappa B zeta protein in complex with the NF-kappa B p50 homodimer. Genes Dev., 38, 2024
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8VJR
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8X2R
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![BU of 8x2r by Molmil](/molmil-images/mine/8x2r) | The Crystal Structure of HSP 90-alpha from Biortus. | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-alpha | Authors: | Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. | Deposit date: | 2023-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Crystal Structure of HSP 90-alpha from Biortus. To Be Published
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8XBE
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![BU of 8xbe by Molmil](/molmil-images/mine/8xbe) | Human GPR34 -Gi complex bound to S3E-LysoPS | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Kawahara, R, Shihoya, W, Nureki, O. | Deposit date: | 2023-12-06 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
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8XI8
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8VI4
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![BU of 8vi4 by Molmil](/molmil-images/mine/8vi4) | TehA from Haemophilus influenzae purified in LMNG | Descriptor: | Tellurite resistance protein TehA homolog | Authors: | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2024-01-03 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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9ATJ
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![BU of 9atj by Molmil](/molmil-images/mine/9atj) | Crystal structure of MERS 3CL protease in complex with a m-chlorobenzyl 2-pyrrolidone inhibitor | Descriptor: | (1R,2S)-2-({N-[({(2S)-1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[({(2S)-1-[(3-chlorophenyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ... | Authors: | Liu, L, Lovell, S, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | Deposit date: | 2024-02-26 | Release date: | 2024-07-10 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies. J.Med.Chem., 67, 2024
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8X2S
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![BU of 8x2s by Molmil](/molmil-images/mine/8x2s) | The Crystal Structure of BPGM from Biortus | Descriptor: | 1,2-ETHANEDIOL, Bisphosphoglycerate mutase | Authors: | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | Deposit date: | 2023-11-10 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal Structure of BPGM from Biortus To Be Published
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8VE3
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![BU of 8ve3 by Molmil](/molmil-images/mine/8ve3) | Unliganded human transthyretin in the compressed conformation | Descriptor: | Transthyretin | Authors: | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | Deposit date: | 2023-12-18 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
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8VAW
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