8SFQ
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7KRV
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7KRT
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3NR2
| Crystal structure of Caspase-6 zymogen | 分子名称: | Caspase-6 | 著者 | Su, X.-D, Wang, X.-J, Liu, X, Mi, W, Wang, K.-T. | 登録日 | 2010-06-30 | 公開日 | 2010-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
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5C5I
| Crystal structure of NADP-dependent dehydrogenase from Rhodobacter sphaeroides | 分子名称: | NADP-dependent dehydrogenase | 著者 | Kowiel, M, Gasiorowska, O.A, Shabalin, I.G, Handing, K.B, Porebski, P.J, Cymborowski, M, Al Obaidi, N.F, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2015-06-19 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of NADP-dependent dehydrogenase from Rhodobacter sphaeroides to be published
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5TA3
| Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 2) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. | 登録日 | 2016-09-09 | 公開日 | 2016-10-12 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
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8SFN
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8SFI
| WT CRISPR-Cas12a with a 8bp R-loop | 分子名称: | CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*TP*TP*AP*TP*CP*AP*CP*TP*AP*AP*AP*AP*GP*AP*TP*CP*GP*GP*AP*AP*G)-3'), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*TP*A)-3'), ... | 著者 | Strohkendl, I, Taylor, D.W. | 登録日 | 2023-04-11 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | WT CRISPR-Cas12a with a 8bp R-loop To Be Published
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8SFP
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8SFH
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5C5S
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8SFR
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8FO4
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4I41
| Crystal Structure of human Ser/Thr kinase Pim1 in complex with mitoxantrone | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Serine/threonine-protein kinase pim-1 | 著者 | Zhang, W, Wan, X, Xie, Y, Huang, N. | 登録日 | 2012-11-27 | 公開日 | 2013-12-11 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J. Med. Chem., 56, 2013
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1DWF
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2XZE
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3M2R
| Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | 分子名称: | 1,2-ETHANEDIOL, 1-THIOETHANESULFONIC ACID, Coenzyme B, ... | 著者 | Cedervall, P.E, Dey, M, Ragsdale, S.W, Wilmot, C.M. | 登録日 | 2010-03-08 | 公開日 | 2010-09-15 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues. Biochemistry, 49, 2010
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2XF0
| Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors | 分子名称: | 1,2-ETHANEDIOL, 3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE, SERINE/THREONINE-PROTEIN KINASE CHK1 | 著者 | Matthews, T.P, McHardy, T, Klair, S, Boxall, K, Fisher, M, Cherry, M, Allen, C.E, Addison, G.J, Ellard, J, Aherne, G.W, Westwood, I.M, van Montfort, R, Garrett, M.D, Reader, J.C, Collins, I. | 登録日 | 2010-05-19 | 公開日 | 2010-06-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases. Bioorg.Med.Chem.Lett., 20, 2010
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3M9K
| Crystal structure of human thioredoxin C69/73S double-mutant, oxidized form | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, SULFATE ION, Thioredoxin | 著者 | Weichsel, A, Montfort, W.R. | 登録日 | 2010-03-22 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of human thioredoxin revealing an unraveled helix and exposed S-nitrosation site. Protein Sci., 19, 2010
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5BVT
| Palmitate-bound pFABP5 | 分子名称: | Epidermal fatty acid-binding protein, PALMITOLEIC ACID | 著者 | Lee, J.H, Lee, C.W, Do, H. | 登録日 | 2015-06-05 | 公開日 | 2015-08-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin Biochem.Biophys.Res.Commun., 465, 2015
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3IR4
| 1.2 Angstrom Crystal Structure of the Glutaredoxin 2 (grxB) from Salmonella typhimurium in complex with Glutathione | 分子名称: | CHLORIDE ION, GLUTATHIONE, Glutaredoxin 2, ... | 著者 | Minasov, G, Wawrzak, Z, Skarina, T, Onopriyenko, O, Peterson, S.N, Halavaty, A, Dauter, Z, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-08-21 | 公開日 | 2009-09-01 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | 1.2 Angstrom Crystal Structure of the Glutaredoxin 2 (grxB) from Salmonella typhimurium in complex with Glutathione. TO BE PUBLISHED
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6GG4
| Crystal structure of M2 PYK in complex with Phenyalanine. | 分子名称: | PHENYLALANINE, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | McNae, I.W, Yuan, M, Walkinshaw, M.D. | 登録日 | 2018-05-02 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem. J., 475, 2018
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5BVS
| Linoleate-bound pFABP4 | 分子名称: | Fatty acid-binding protein, LINOLEIC ACID | 著者 | Lee, J.H, Lee, C.W, Do, H. | 登録日 | 2015-06-05 | 公開日 | 2015-08-05 | 最終更新日 | 2015-09-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin Biochem.Biophys.Res.Commun., 465, 2015
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6VH3
| 2.20 A resolution structure of MERS 3CL protease in complex with inhibitor 7j | 分子名称: | (1S,2S)-2-[(N-{[(4,4-difluorocyclohexyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, Orf1a protein | 著者 | Lovell, S, Battaile, K.P, Kashipathy, M.M, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. | 登録日 | 2020-01-09 | 公開日 | 2020-08-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med, 12, 2020
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4E2F
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