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PDB: 5 件
6PAI
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BU of 6pai by Molmil
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820
分子名称: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DDB1- and CUL4-associated factor 15, ...
著者Volkov, O.A, Du, X.
登録日2019-06-11
公開日2019-09-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820.
Structure, 27, 2019
6BM7
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BU of 6bm7 by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
分子名称: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium, ...
著者Volkov, O.A, Chen, Z, Phillips, M.A.
登録日2017-11-13
公開日2018-01-03
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.
J. Med. Chem., 61, 2018
5TVO
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BU of 5tvo by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer
分子名称: PYRUVIC ACID, S-adenosylmethionine decarboxylase proenzyme, SODIUM ION
著者Volkov, O.A, Ariagno, C, Chen, Z, Tomchick, D.R, Phillips, M.A.
登録日2016-11-09
公開日2016-12-28
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.481 Å)
主引用文献Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
5TVM
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BU of 5tvm by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer
分子名称: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase alpha chain, ...
著者Volkov, O.A, Chen, Z, Tomchick, D.R, Phillips, M.A.
登録日2016-11-09
公開日2017-01-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.408 Å)
主引用文献Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
5TVF
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BU of 5tvf by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
分子名称: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ...
著者Phillips, M.A, Volkov, O.A, Chen, Z, Tomchick, D.R.
登録日2016-11-08
公開日2017-01-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016

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件を2024-10-09に公開中

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