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PDB: 22 件
8BQ3
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BU of 8bq3 by Molmil
Crystal structure of human R13 mutant of the c-Src SH3 domain in complex with VSL12-peptide
分子名称: PRO-LEU-PRO, Proto-oncogene tyrosine-protein kinase Src
著者Varejao, N, Navarro, S, Ventura, S, Reverter, D.
登録日2022-11-18
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Crystal structure of human R13 mutant of the c-Src SH3 domain in complex with VSL12-peptide
To Be Published
5LCN
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BU of 5lcn by Molmil
STRUCTURE OF THE PYROCOCCUS FURIOSUS ESTERASE PF2001 WITH SPACE GROUP P212121
分子名称: PENTAETHYLENE GLYCOL, Uncharacterized protein
著者Varejao, N, Reverter, D.
登録日2016-06-22
公開日2017-08-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
7QC5
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BU of 7qc5 by Molmil
Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound
分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin
著者Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
登録日2021-11-22
公開日2022-11-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
J.Med.Chem., 65, 2022
6XTK
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BU of 6xtk by Molmil
Y114C Transthyretin structure in complex with Tolcalpone
分子名称: Tolcapone, Transthyretin
著者Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
登録日2020-01-16
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
6TXW
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BU of 6txw by Molmil
V30G Transthyretin structure in complex with Tolcalpone
分子名称: Tolcapone, Transthyretin
著者Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
登録日2020-01-14
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.153 Å)
主引用文献Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
6TXV
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BU of 6txv by Molmil
A25T Transthyretin structure in complex with Tolcalpone
分子名称: Tolcapone, Transthyretin
著者Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
登録日2020-01-14
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
5FO2
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BU of 5fo2 by Molmil
Structure of human transthyretin mutant A108I
分子名称: TRANSTHYRETIN
著者Varejao, N, Santanna, R, Saraiva, M.J, Gallego, P, Ventura, S, Reverter, D.
登録日2015-11-17
公開日2016-11-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.449 Å)
主引用文献Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
6FWW
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BU of 6fww by Molmil
GFP/KKK. A redesigned GFP with improved solubility
分子名称: Green fluorescent protein
著者Varejao, N, Lascorz, J, Gil-Garcia, M, Diaz-Caballero, M, Navarro, S, Ventura, S, Reverter, D.
登録日2018-03-07
公開日2018-08-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.131 Å)
主引用文献Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.
Mol. Pharm., 15, 2018
6FXU
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BU of 6fxu by Molmil
Crystal structure of human transthyretin mutant T119M at pH 5.5
分子名称: Transthyretin
著者Varejao, N, Esperante, S, Ventura, S, Reverter, D.
登録日2018-03-09
公開日2019-03-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.359 Å)
主引用文献Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
5G5M
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BU of 5g5m by Molmil
Structure of the Pyrococcus Furiosus Esterase Pf2001 with space group P21
分子名称: ESTERASE, S-methyl hexanethioate
著者Varejao, N, Reverter, D.
登録日2016-05-26
公開日2017-06-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
8PM9
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BU of 8pm9 by Molmil
Crystal structure of human wild type transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
著者Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
登録日2023-06-28
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
8PM8
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BU of 8pm8 by Molmil
V30M Transthyretin structure in complex with Tolcalpone
分子名称: Tolcapone, Transthyretin
著者Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
登録日2023-06-28
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
8PMO
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BU of 8pmo by Molmil
Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
著者Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
登録日2023-06-29
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
8PMA
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BU of 8pma by Molmil
Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
分子名称: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
著者Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
登録日2023-06-28
公開日2024-05-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
5G5C
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BU of 5g5c by Molmil
Structure of the Pyrococcus furiosus Esterase Pf2001 with space group C2221
分子名称: ESTERASE
著者Varejao, N, Reverter, D.
登録日2016-05-23
公開日2017-06-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
5G59
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BU of 5g59 by Molmil
Structure of the Pyrococcus Furiosus Esterase Pf2001 with space group P3121
分子名称: ESTERASE, MERCURY (II) ION
著者Varejao, N, Reverter, D.
登録日2016-05-23
公開日2017-06-21
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.613 Å)
主引用文献Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
7P47
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BU of 7p47 by Molmil
Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic
分子名称: E3 SUMO-protein ligase MMS21, SUMO-conjugating enzyme UBC9, Structural maintenance of chromosomes protein 5, ...
著者Lascorz, J, Varejao, N, Reverter, D.
登録日2021-07-09
公開日2021-11-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.314 Å)
主引用文献Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.
Nat Commun, 12, 2021
5FW6
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BU of 5fw6 by Molmil
Structure of human transthyretin mutant A108V
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
6FZL
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BU of 6fzl by Molmil
Crystal structure of human transthyretin double mutant K35T/T119M
分子名称: Transthyretin
著者Esperante, S, Ventura, S, Reverter, D, Varejao, N.
登録日2018-03-15
公開日2019-03-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.446 Å)
主引用文献Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
6FWD
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BU of 6fwd by Molmil
Crystal structure of human transthyretin double mutant R34G/T119M at pH 5.5
分子名称: Transthyretin
著者Esperante, S, Ventura, S, Reverter, D, Varejao, N.
登録日2018-03-06
公開日2019-03-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.576 Å)
主引用文献Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.
J.Biol.Chem., 297, 2021
5FW8
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BU of 5fw8 by Molmil
Structure of human transthyretin mutant E89K
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2016-12-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
5FW7
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BU of 5fw7 by Molmil
Structure of human transthyretin mutant A109V
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published

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件を2024-11-06に公開中

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