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PDB: 14 件
6L22
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BU of 6l22 by Molmil
Crystal structure of CK2a1 H115Y with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, Casein kinase II subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.12318087 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
6L23
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BU of 6l23 by Molmil
Crystal structure of CK2a1 V116I with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, 1,2-ETHANEDIOL, Casein kinase II subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.97449422 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
7BU4
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BU of 7bu4 by Molmil
Crystal structure of CK2a1 complexed with KY49
分子名称: 4-(6-aminocarbonyl-8-oxidanylidene-9-phenyl-7H-purin-2-yl)benzoic acid, Casein Kinase 2 subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2020-04-04
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.70227313 Å)
主引用文献Design, synthesis and SAR studies of protein kinase CK2 inhibitors with a purine scaffold
To Be Published
5YF9
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BU of 5yf9 by Molmil
Crystal structure of CK2a2 form-2
分子名称: Casein kinase II subunit alpha', NICOTINIC ACID, SULFATE ION
著者Tsuyuguchi, M, Kinoshita, T.
登録日2017-09-20
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structures of human CK2 alpha 2 in new crystal forms arising from a subtle difference in salt concentration
Acta Crystallogr F Struct Biol Commun, 74, 2018
5Y9M
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BU of 5y9m by Molmil
Crystal structure of CK2a2 form 3
分子名称: Casein kinase II subunit alpha', NICOTINIC ACID, SULFATE ION
著者Tsuyuguchi, M, Kinoshita, T.
登録日2017-08-25
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Crystal structures of human CK2 alpha 2 in new crystal forms arising from a subtle difference in salt concentration
Acta Crystallogr F Struct Biol Commun, 74, 2018
6JWA
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BU of 6jwa by Molmil
Crystal structure of CK2a1 with 5-iodotubercidin
分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, Casein kinase II subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-04-19
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.781 Å)
主引用文献A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1.
Acta Crystallogr.,Sect.F, 75, 2019
5YWM
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BU of 5ywm by Molmil
Crystal structure of CK2a2 form-1
分子名称: Casein kinase II subunit alpha', NICOTINIC ACID, SULFATE ION
著者Tsuyuguchi, M, Kinoshita, T.
登録日2017-11-29
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.939 Å)
主引用文献Crystal structure of human CK2a2 in a new crystal form at 1.89 angstrom resolution
To Be Published
6L1Z
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BU of 6l1z by Molmil
Crystal structure of CK2a1 with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, Casein Kinase 2 subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.90820944 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
6L20
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BU of 6l20 by Molmil
Crystal structure of CK2a2 with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, CHLORIDE ION, Casein kinase II subunit alpha'
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.08735132 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
6L21
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BU of 6l21 by Molmil
Crystal structure of CK2a1 H160A with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, Casein kinase II subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05451775 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
6L24
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BU of 6l24 by Molmil
Crystal structure of CK2a1 H115Y/V116I with hematein
分子名称: (6aR)-3,4,6a,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2,1-c]chromen-9-one, Casein kinase II subunit alpha
著者Tsuyuguchi, M, Kinoshita, T.
登録日2019-10-02
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.400095 Å)
主引用文献Structural insights for producing CK2 alpha 1-specific inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
7XYH
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BU of 7xyh by Molmil
Crystal structure of CK2a2 complexed with AG1112
分子名称: 1,2-ETHANEDIOL, 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, Casein kinase II subunit alpha'
著者Ikeda, A, Kinoshita, T, Tsuyuguchi, M.
登録日2022-06-01
公開日2023-01-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors.
Biochem.Biophys.Res.Commun., 630, 2022
7X4H
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BU of 7x4h by Molmil
Crystal structure of CK2a1 complexed with AG1112
分子名称: 5-azanyl-3-[(~{Z})-1-cyano-2-(1~{H}-indol-3-yl)ethenyl]-1~{H}-pyrazole-4-carbonitrile, Casein Kinase 2 subunit alpha
著者Ikeda, A, Kinoshita, T, Tsuyuguchi, M.
登録日2022-03-02
公開日2023-01-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2 alpha 1-selective inhibitors.
Biochem.Biophys.Res.Commun., 630, 2022
6A1C
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BU of 6a1c by Molmil
Crystal structure of the CK2a1-go289 complex
分子名称: 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, Casein kinase II subunit alpha, ...
著者Kinoshita, T, Tsuyuguchi, M.
登録日2018-06-07
公開日2019-03-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
Sci Adv, 5, 2019

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件を2024-07-17に公開中

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