1WPG
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![BU of 1wpg by Molmil](/molmil-images/mine/1wpg) | Crystal structure of the SR CA2+-ATPase with MGF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Nomura, H, Tsuda, T. | Deposit date: | 2004-09-02 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues Nature, 432, 2004
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1VFP
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1SU4
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![BU of 1su4 by Molmil](/molmil-images/mine/1su4) | Crystal structure of calcium ATPase with two bound calcium ions | Descriptor: | CALCIUM ION, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Authors: | Toyoshima, C, Nakasako, M, Nomura, H, Ogawa, H. | Deposit date: | 2004-03-26 | Release date: | 2004-05-04 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution Nature, 405, 2000
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1IWO
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![BU of 1iwo by Molmil](/molmil-images/mine/1iwo) | |
2DQS
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2AGV
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![BU of 2agv by Molmil](/molmil-images/mine/2agv) | Crystal structure of the SR CA2+-ATPASE with BHQ and TG | Descriptor: | 2,5-DITERT-BUTYLBENZENE-1,4-DIOL, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Toyoshima, C, Obara, K, Norimatsu, Y. | Deposit date: | 2005-07-27 | Release date: | 2005-10-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inaugural Article: Structural role of countertransport revealed in Ca2+ pump crystal structure in the absence of Ca2+. Proc.Natl.Acad.Sci.USA, 102, 2005
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2ZBG
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![BU of 2zbg by Molmil](/molmil-images/mine/2zbg) | Calcium pump crystal structure with bound AlF4 and TG in the absence of calcium | Descriptor: | MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Toyoshima, C, Ogawa, H, Norimatsu, Y. | Deposit date: | 2007-10-20 | Release date: | 2007-12-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ZBF
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![BU of 2zbf by Molmil](/molmil-images/mine/2zbf) | Calcium pump crystal structure with bound BeF3 and TG in the absence of calcium | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Ogawa, H, Norimatsu, Y. | Deposit date: | 2007-10-20 | Release date: | 2007-12-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ZBE
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2ZBD
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![BU of 2zbd by Molmil](/molmil-images/mine/2zbd) | Crystal Structure of the SR Calcium Pump with Bound Aluminium Fluoride, ADP and Calcium | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Toyoshima, C, Nomura, H, Tsuda, T, Ogawa, H, Norimatsu, Y. | Deposit date: | 2007-10-20 | Release date: | 2007-11-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues Nature, 432, 2004
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3W5B
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![BU of 3w5b by Molmil](/molmil-images/mine/3w5b) | Crystal structure of the recombinant SERCA1a (calcium pump of fast twitch skeletal muscle) in the E1.Mg2+ state | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3W5A
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![BU of 3w5a by Molmil](/molmil-images/mine/3w5a) | Crystal structure of the calcium pump and sarcolipin from rabbit fast twitch skeletal muscle in the E1.Mg2+ state | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3W5D
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![BU of 3w5d by Molmil](/molmil-images/mine/3w5d) | Crystal structure of the calcium pump in the E2+Pi state | Descriptor: | PHOSPHATIDYLETHANOLAMINE, SERCA1a, SODIUM ION, ... | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3W5C
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![BU of 3w5c by Molmil](/molmil-images/mine/3w5c) | Crystal structure of the calcium pump in the E2 state free from exogenous inhibitors | Descriptor: | PHOSPHATIDYLETHANOLAMINE, SERCA1a, SODIUM ION | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | Deposit date: | 2013-01-27 | Release date: | 2013-03-06 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state. Nature, 495, 2013
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3AR4
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![BU of 3ar4 by Molmil](/molmil-images/mine/3ar4) | Calcium pump crystal structure with bound ATP and TG in the absence of Ca2+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR3
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![BU of 3ar3 by Molmil](/molmil-images/mine/3ar3) | Calcium pump crystal structure with bound ADP and TG | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR9
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![BU of 3ar9 by Molmil](/molmil-images/mine/3ar9) | Calcium pump crystal structure with bound BeF3, TNP-AMP and TG in the absence of calcium | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR8
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![BU of 3ar8 by Molmil](/molmil-images/mine/3ar8) | Calcium pump crystal structure with bound AlF4, TNP-AMP and TG | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR6
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![BU of 3ar6 by Molmil](/molmil-images/mine/3ar6) | Calcium pump crystal structure with bound TNP-ADP and TG in the absence of calcium | Descriptor: | 2',3'-O-[(1R,6R)-2,4,6-trinitrocyclohexa-2,4-diene-1,1-diyl]adenosine 5'-(trihydrogen diphosphate), MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+. Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR2
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![BU of 3ar2 by Molmil](/molmil-images/mine/3ar2) | Calcium pump crystal structure with bound AMPPCP and Ca2+ | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR5
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![BU of 3ar5 by Molmil](/molmil-images/mine/3ar5) | Calcium pump crystal structure with bound TNP-AMP and TG | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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3AR7
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![BU of 3ar7 by Molmil](/molmil-images/mine/3ar7) | Calcium pump crystal structure with bound TNP-ATP and TG in the absence of Ca2+ | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Toyoshima, C, Yonekura, S, Tsueda, J, Iwasawa, S. | Deposit date: | 2010-11-24 | Release date: | 2011-02-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+ Proc.Natl.Acad.Sci.USA, 108, 2011
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4YCM
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![BU of 4ycm by Molmil](/molmil-images/mine/4ycm) | Crystal structure of the calcium pump with bound marine macrolide BLS | Descriptor: | (4S,5E,8S,9E,11S,13E,15E,18R)-8-methoxy-9,11-dimethyl-18-[(1Z,4E)-2-methylhexa-1,4-dien-1-yl]-2-oxooxacyclooctadeca-5,9,13,15-tetraen-4-yl 3-O-methyl-beta-D-glucopyranoside, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | Authors: | Morita, M, Ogawa, H, Ohno, O, Yamori, T, Suenaga, K, Toyoshima, C. | Deposit date: | 2015-02-20 | Release date: | 2016-01-13 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding Febs Lett., 589, 2015
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8XEJ
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![BU of 8xej by Molmil](/molmil-images/mine/8xej) | Cryo-EM structure of human XKR8-basigin complex in lipid nanodisc | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Fab heavy chain, Fab light chain, ... | Authors: | Sakuragi, T.S, Kanai, R.K, Kikkawa, M.K, Toyoshima, C.T, Nagata, S.N. | Deposit date: | 2023-12-12 | Release date: | 2024-02-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase. J.Biol.Chem., 300, 2024
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7D94
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![BU of 7d94 by Molmil](/molmil-images/mine/7d94) | Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the presence of bufalin | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | Deposit date: | 2020-10-12 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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