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PDB: 37 件
7C03
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Crystal structure of POLArISact(T57S), genetically encoded probe for fluorescent polarization
分子名称: POLArISact(T57S)
著者Tomabechi, Y, Sakai, N, Shirouzu, M.
登録日2020-04-30
公開日2021-03-17
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos.
Proc.Natl.Acad.Sci.USA, 118, 2021
5B0U
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BU of 5b0u by Molmil
Crystal structure of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ)
分子名称: Oplophorus-luciferin 2-monooxygenase catalytic subunit
著者Tomabechi, Y, Ehara, H, Sekine, S.I, Shirouzu, M.
登録日2015-11-04
公開日2016-01-13
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine
Biochem.Biophys.Res.Commun., 470, 2016
5ZJ6
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BU of 5zj6 by Molmil
Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Tyrosine-protein kinase HCK
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2018-03-19
公開日2018-06-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.
Protein Expr. Purif., 150, 2018
7VSX
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Crystal structure of QL-nanoKAZ (Reverse mutant of nanoKAZ with L18Q and V27L)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, QLnK
著者Tomabechi, Y, Sekine, S, Shirouzu, M, Takamitsu, H, Satoshi, I.
登録日2021-10-27
公開日2022-08-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate.
Plos One, 17, 2022
7EG2
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Crystal structure of the apoAequorin complex with (S)-daCTZ
分子名称: (2~{S})-2-(hydroxymethyl)-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-4-(phenylmethyl)-3~{H}-inden-1-one, Aequorin-2
著者Tomabechi, Y, Shirouzu, M.
登録日2021-03-24
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin.
Plos One, 16, 2021
7EG3
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Crystal structure of the apoAequorin complex with (S)-HM-daCTZ
分子名称: (2~{S})-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-4-(phenylmethyl)-2,3-dihydroinden-1-one, Aequorin-2
著者Tomabechi, Y, Shirouzu, M.
登録日2021-03-24
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin.
Plos One, 16, 2021
5GV0
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Crystal structure of the membrane-proximal domain of mouse lysosome-associated membrane protein 1 (LAMP-1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome-associated membrane glycoprotein 1, SULFATE ION
著者Tomabechi, Y, Ehara, H, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-09-01
公開日2016-10-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes
Biochem.Biophys.Res.Commun., 479, 2016
5GV3
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Crystal structure of the membrane-distal domain of mouse lysosome-associated membrane protein 2 (LAMP-2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome-associated membrane glycoprotein 2, ZINC ION
著者Tomabechi, Y, Ehara, H, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-09-01
公開日2017-09-06
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.
Biochem. Biophys. Res. Commun., 479, 2016
5H0B
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BU of 5h0b by Molmil
Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid
分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate, Tyrosine-protein kinase HCK
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-10-04
公開日2017-10-11
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg. Med. Chem., 25, 2017
5H0E
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Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanamide
分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide, Tyrosine-protein kinase HCK
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-10-04
公開日2017-10-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg. Med. Chem., 25, 2017
5H0H
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Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,N,4-trimethylpentanamide
分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},~{N},4-trimethyl-pentanamide, Tyrosine-protein kinase HCK
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-10-04
公開日2017-10-04
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg. Med. Chem., 25, 2017
5H0G
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Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,4-dimethylpentanamide
分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},4-dimethyl-pentanamide, Tyrosine-protein kinase HCK
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-10-04
公開日2017-10-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg. Med. Chem., 25, 2017
5H09
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BU of 5h09 by Molmil
Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-ethyl2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate
分子名称: Tyrosine-protein kinase HCK, ethyl (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate
著者Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M.
登録日2016-10-04
公開日2017-10-04
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.945 Å)
主引用文献Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg. Med. Chem., 25, 2017
4LUD
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BU of 4lud by Molmil
Crystal Structure of HCK in complex with the fluorescent compound SKF86002
分子名称: 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, CHLORIDE ION, ...
著者Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
登録日2013-07-25
公開日2014-02-12
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014
5X1A
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BU of 5x1a by Molmil
Crystal Structure of Human CRMP-2
分子名称: Dihydropyrimidinase-related protein 2
著者Nitta, R, Tomabechi, Y, Aoki, M, Shirouzu, M.
登録日2017-01-25
公開日2017-09-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.821 Å)
主引用文献Structural basis for CRMP2-induced axonal microtubule formation
Sci Rep, 7, 2017
5X1D
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BU of 5x1d by Molmil
Crystal Structure of T246A-N247A Human CRMP-2 Mutant
分子名称: Dihydropyrimidinase-related protein 2
著者Nitta, R, Tomabechi, Y, Aoki, M, Shirouzu, M.
登録日2017-01-25
公開日2017-09-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for CRMP2-induced axonal microtubule formation
Sci Rep, 7, 2017
8W9G
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BU of 8w9g by Molmil
Hepatitis B virus core protein Y132A mutant in complex with CBT-078
分子名称: 2-fluoranyl-N1-(4-fluorophenyl)-N3-(2-methylphenyl)benzene-1,3-dicarboxamide, Capsid protein
著者Iwasaki, W, Katsura, K, Tomabechi, Y, Niwa, H, Ogawa, K, Kojima, S, Shirouzu, M.
登録日2023-09-05
公開日2024-09-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Screening systems for the detection of hepatitis B virus replication and capsid assembly
To Be Published
4WR5
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BU of 4wr5 by Molmil
Crystal Structure of GST Mutated with Halogenated Tyrosine (7cGST-1)
分子名称: GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme, SULFATE ION
著者Akasaka, R, Kawazoe, M, Tomabechi, Y, Ohtake, K, Itagaki, T, Takemoto, C, Shirouzu, M, Yokoyama, S, Sakamoto, K.
登録日2014-10-23
公開日2015-08-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Protein stabilization utilizing a redefined codon
Sci Rep, 5, 2015
4WR4
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Crystal Structure of GST Mutated with Halogenated Tyrosine (7bGST-1)
分子名称: GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme, SULFATE ION
著者Akasaka, R, Kawazoe, M, Tomabechi, Y, Ohtake, K, Itagaki, T, Takemoto, C, Shirouzu, M, Yokoyama, S, Sakamoto, K.
登録日2014-10-23
公開日2015-08-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Protein stabilization utilizing a redefined codon
Sci Rep, 5, 2015
3QHE
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BU of 3qhe by Molmil
Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68
分子名称: Adenomatous polyposis coli protein, KH domain-containing, RNA-binding, ...
著者Morishita, E.C.J, Murayama, K, Kato-Murayama, M, Ishizuku-Katsura, Y, Tomabechi, Y, Terada, T, Handa, N, Shirouzu, M, Akiyama, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2011-01-25
公開日2011-11-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68
Structure, 19, 2011
5ZAB
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BU of 5zab by Molmil
Crystal structure of cf3-aequorin
分子名称: (2S)-8-benzyl-2-hydroperoxy-6-(4-hydroxyphenyl)-2-{[4-(trifluoromethyl)phenyl]methyl}imidazo[1,2-a]pyrazin-3(2H)-one, Aequorin-2
著者Inouye, S, Tomabechi, Y, Sekine, S.I, Shirouzu, M, Hosoya, T.
登録日2018-02-07
公開日2018-06-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.147 Å)
主引用文献Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.
J. Biochem., 164, 2018
4LM5
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BU of 4lm5 by Molmil
Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002)
分子名称: 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, GLYCEROL, Serine/threonine-protein kinase pim-1
著者Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
登録日2013-07-10
公開日2014-02-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014
4LMU
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BU of 4lmu by Molmil
Crystal structure of Pim1 in complex with the inhibitor Quercetin (resulting from displacement of SKF86002)
分子名称: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, GLYCEROL, Serine/threonine-protein kinase pim-1
著者Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
登録日2013-07-11
公開日2014-02-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014
4LL5
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BU of 4ll5 by Molmil
Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002
分子名称: 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, GLYCEROL, ...
著者Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
登録日2013-07-09
公開日2014-02-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014
4LUE
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BU of 4lue by Molmil
Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (resulting from displacement of SKF86002)
分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ...
著者Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
登録日2013-07-25
公開日2014-02-12
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014

 

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