5ZJ6

Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Summary for 5ZJ6

• Entry DOI: 10.2210/pdb5zj6/pdb
• Descriptor: Tyrosine-protein kinase HCK, 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: kinase/kinase inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 66170.29

Authors

Tomabechi, Y.,Kukimoto-Niino, M.,Shirouzu, M. (deposition date: 2018-03-19, release date: 2018-06-06, Last modification date: 2023-11-22)

• Primary citation: Katsura, K.,Tomabechi, Y.,Matsuda, T.,Yonemochi, M.,Mikuni, J.,Ohsawa, N.,Terada, T.,Yokoyama, S.,Kukimoto-Niino, M.,Takemoto, C.,Shirouzu, M.; Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.; Protein Expr. Purif., 150:92-99, 2018; PubMed: 29793032; DOI: 10.1016/j.pep.2018.05.005

Experimental method

X-RAY DIFFRACTION (1.696 Å)