Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue VSE A 601 |
| Chain | Residue |
| A | LEU273 |
| A | ASP404 |
| A | HOH770 |
| A | HOH825 |
| A | VAL281 |
| A | ALA293 |
| A | LYS295 |
| A | THR338 |
| A | GLU339 |
| A | MET341 |
| A | ASP348 |
| A | LEU393 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue VSE B 601 |
| Chain | Residue |
| B | LEU273 |
| B | VAL281 |
| B | ALA293 |
| B | LYS295 |
| B | MET314 |
| B | THR338 |
| B | GLU339 |
| B | MET341 |
| B | ASP348 |
| B | LEU393 |
| B | ASP404 |
| B | PHE405 |
| B | HOH799 |
| B | HOH823 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmAtynkhtk...........VAVK |
| Chain | Residue | Details |
| A | LEU273-LYS295 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANILV |
| Chain | Residue | Details |
| A | TYR382-VAL394 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 506 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"10644735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11896602","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
