4LL5

Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002

Summary for 4LL5

Entry DOI	10.2210/pdb4ll5/pdb
Related	4LM5 4LMU 4LUD 4LUE
Descriptor	Serine/threonine-protein kinase pim-1, 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, GLYCEROL, ... (5 entities in total)
Functional Keywords	co-crystallization, skf86002, fluorescence, inhibitor screening, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34893.53
Authors	Parker, L.J.,Tanaka, A.,Handa, N.,Honda, K.,Tomabechi, Y.,Shirouzu, M.,Yokoyama, S. (deposition date: 2013-07-09, release date: 2014-02-12, Last modification date: 2023-11-08)
Primary citation	Parker, L.J.,Taruya, S.,Tsuganezawa, K.,Ogawa, N.,Mikuni, J.,Honda, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yokoyama, S.,Tanaka, A. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70:392-404, 2014 Cited by PubMed: 24531473 DOI: 10.1107/S1399004713028654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation