4LL5
Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase pim-1 | polymer | 298 | 34187.7 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (human) | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 |
2 | A | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole | non-polymer | 297.4 | 1 | Chemie (SK8) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A: 29 - 313 (UniProt: P11309)
PDB | External Database | Details |
---|---|---|
Met 28 | - | expression tag |
Ser 314 | - | expression tag |
Gly 315 | - | expression tag |
Pro 316 | - | expression tag |
Ser 317 | - | expression tag |
Ser 318 | - | expression tag |
Gly 319 | - | expression tag |
Glu 320 | - | expression tag |
Asn 321 | - | expression tag |
Leu 322 | - | expression tag |
Tyr 323 | - | expression tag |
Phe 324 | - | expression tag |
Gln 325 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34187.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 705.8 | |
All* | Total formula weight | 34893.5 |