4LM5
Crystal structure of Pim1 in complex with 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol (resulting from displacement of SKF86002)
Summary for 4LM5
| Entry DOI | 10.2210/pdb4lm5/pdb |
| Related | 4LL5 4LMU 4LUD 4LUE |
| Descriptor | Serine/threonine-protein kinase pim-1, 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | co-crystallization, skf86002, fluorescence, inhibitor screening, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34774.36 |
| Authors | Parker, L.J.,Tanaka, A.,Handa, N.,Honda, K.,Tomabechi, Y.,Shirouzu, M.,Yokoyama, S. (deposition date: 2013-07-10, release date: 2014-02-12, Last modification date: 2023-12-06) |
| Primary citation | Parker, L.J.,Taruya, S.,Tsuganezawa, K.,Ogawa, N.,Mikuni, J.,Honda, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yokoyama, S.,Tanaka, A. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70:392-404, 2014 Cited by PubMed: 24531473DOI: 10.1107/S1399004713028654 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
Download full validation report
