8WUU
 
 | | SpCas9-pegRNA-target DNA complex (pre-initiation) | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (34-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... | | 著者 | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | | 登録日 | 2023-10-21 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
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5Y5N
 | | Crystal structure of human Sirtuin 2 in complex with a selective inhibitor | | 分子名称: | 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION | | 著者 | Mellini, P, Itoh, Y, Tsumoto, H, Li, Y, Suzuki, M, Tokuda, N, Kakizawa, T, Miura, Y, Takeuchi, J, Lahtela-Kakkonen, M, Suzuki, T. | | 登録日 | 2017-08-09 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.
Chem Sci, 8, 2017
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1WRD
 | | Crystal structure of Tom1 GAT domain in complex with ubiquitin | | 分子名称: | Target of Myb protein 1, Ubiquitin | | 著者 | Akutsu, M, Kawasaki, M, Katoh, Y, Shiba, T, Yamaguchi, Y, Kato, R, Kato, K, Nakayama, K, Wakatsuki, S. | | 登録日 | 2004-10-14 | | 公開日 | 2005-10-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
Febs Lett., 579, 2005
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2N37
 | | Solution structure of AVR-Pia | | 分子名称: | AVR-Pia protein | | 著者 | Ose, T, Oikawa, A, Nakamura, Y, Maenaka, K, Higuchi, Y, Satoh, Y, Fujiwara, S, Demura, M, Sone, T. | | 登録日 | 2015-05-25 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of an avirulence protein, AVR-Pia, from Magnaporthe oryzae
J.Biomol.Nmr, 63, 2015
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6IKO
 | | Crystal structure of mouse GAS7cb | | 分子名称: | Growth arrest-specific protein 7 | | 著者 | Hanawa-Suetsugu, K, Itoh, Y, Kohda, D, Shimada, A, Suetsugu, S. | | 登録日 | 2018-10-16 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.756 Å) | | 主引用文献 | Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.
Nat Commun, 10, 2019
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6IKN
 | | Crystal structure of the GAS7 F-BAR domain | | 分子名称: | Growth arrest-specific protein 7 | | 著者 | Hanawa-Suetsugu, K, Itoh, Y, Kohda, D, Shimada, A, Suetsugu, S. | | 登録日 | 2018-10-16 | | 公開日 | 2019-10-16 | | 最終更新日 | 2019-10-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.
Nat Commun, 10, 2019
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1WZZ
 | | Structure of endo-beta-1,4-glucanase CMCax from Acetobacter xylinum | | 分子名称: | Probable endoglucanase, SULFATE ION | | 著者 | Yasutake, Y, Kawano, S, Tajima, K, Yao, M, Satoh, Y, Munekata, M, Tanaka, I, Structural Genomics Consortium (SGC) | | 登録日 | 2005-03-10 | | 公開日 | 2006-03-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural characterization of the Acetobacter xylinum endo-beta-1,4-glucanase CMCax required for cellulose biosynthesis.
Proteins, 64, 2006
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3C7X
 | | Hemopexin-like domain of matrix metalloproteinase 14 | | 分子名称: | CHLORIDE ION, Matrix metalloproteinase-14, SODIUM ION | | 著者 | Tochowicz, A, Itoh, Y, Maskos, K, Bode, W, Goettig, P. | | 登録日 | 2008-02-08 | | 公開日 | 2009-02-10 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions
J.Biol.Chem., 286, 2011
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3WVR
 | | Structure of ATP grasp protein with AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, GLYCEROL, PGM1, ... | | 著者 | Matsui, T, Noike, M, Ooya, K, Sasaki, I, Hamano, Y, Maruyama, C, Ishikawa, J, Satoh, Y, Ito, H, Dairi, T, Morita, H. | | 登録日 | 2014-06-04 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin.
Nat.Chem.Biol., 11, 2015
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3WVQ
 | | Structure of ATP grasp protein | | 分子名称: | GLYCEROL, PGM1, SULFATE ION | | 著者 | Matsui, T, Noike, M, Ooya, K, Sasaki, I, Hamano, Y, Maruyama, C, Ishikawa, J, Satoh, Y, Ito, H, Dairi, T, Morita, H. | | 登録日 | 2014-06-04 | | 公開日 | 2014-11-19 | | 最終更新日 | 2014-12-31 | | 実験手法 | X-RAY DIFFRACTION (1.955 Å) | | 主引用文献 | A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin.
Nat.Chem.Biol., 11, 2015
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3TTI
 | | Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 10, trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | | 著者 | Plantevin-Krenitsky, V, Nadolny, L, Delgado, M, Ayala, L, Clareen, S, Hilgraf, R, Albers, R, Hegde, S, D'Sidocky, N, Sapienza, J, Wright, J, McCarrick, M, Bahmanyar, S, Chamberlain, P, Delker, S.L, Muir, J, Giegel, D, Xu, L, Celeridad, M, Lachowitzer, J, Bennett, B, Moghaddam, M, Khatsenko, O, Katz, J, Fan, R, Bai, A, Tang, Y, Shirley, M.A, Benish, B, Bodine, T, Blease, K, Raymon, H, Cathers, B.E, Satoh, Y. | | 登録日 | 2011-09-14 | | 公開日 | 2012-02-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
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3TTJ
 | | Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury | | 分子名称: | 9-cyclopentyl-N~8~-(2-fluorophenyl)-N~2~-(4-methoxyphenyl)-9H-purine-2,8-diamine, Mitogen-activated protein kinase 10 | | 著者 | Plantevin-Krenitsky, V, Delgado, M, Nadolny, L, Sahasrabudhe, K, Ayala, S, Clareen, S, Hilgraf, R, Albers, R, Kois, A, Hughes, K, Wright, J, Nowakowski, J, Sudbeck, E, Ghosh, S, Bahmanyar, S, Chamberlain, P, Muir, J, Cathers, B.E, Giegel, D, Xu, L, Celeridad, M, Moghaddam, M, Khatsenko, O, Omholt, P, Katz, J, Pai, S, Fan, R, Tang, Y, Shirley, M.A, Benish, B, Blease, K, Raymon, H, Bhagwat, S, Bennett, B, Satoh, Y. | | 登録日 | 2011-09-14 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.
Bioorg.Med.Chem.Lett., 22, 2012
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3WO9
 | | Crystal structure of the lamprey variable lymphocyte receptor C | | 分子名称: | Variable lymphocyte receptor C | | 著者 | Kanda, R, Sutoh, Y, Kasamatsu, J, Maenaka, K, Kasahara, M, Ose, T. | | 登録日 | 2013-12-20 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module.
Plos One, 9, 2014
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